Abstract: A computer-implemented method, including storing information regarding an allowed or disallowed operation of a vehicle or vehicle system, a premises or premises system, or an article in, on, or in the vicinity of, a vehicle or premises or associated with a respective user, operator, passenger, or occupant, of the vehicle or premises, determining, with or using a processing device or computer, an operating or an operational status, condition, or state, of the vehicle or the premises, processing, with or using the processing device or computer, information for controlling, disabling, enabling, or monitoring, an operation of the vehicle, the premises, or the article, in response to the determined operating or an operational status, condition, or state, and generating or transmitting, with the processing device or with the computer, a control signal which controls, disables, enables, or monitors, an operation of the vehicle, the premises, or the article.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: Run-time, event-driven virtual machine introspection of the target guest virtual machine is facilitated as described herein. A component can specify events that are of interest to the component for introspection of a target guest virtual machine of a hypervisor. The hypervisor detects an introspection event generated by a target guest virtual machine and determines whether the introspection event is of interest for handling by a component coupled to the hypervisor. If so, the hypervisor alerts the component about the introspection event and provides information associated with the introspection event to the component. The component thereby receives notification of occurrence of the introspection event from the hypervisor and may obtain information associated with the introspection event.

Abstract: Systems and programs for controlling thrust in a turbine by adjusting the clearance between a packing seal and a rotating component are disclosed. In one embodiment, a system includes a controller configured to move a packing seal to a selected clearance position in response to a thrust pressure exceeding a target pressure, and a sensor coupled to the controller and configured to detect the thrust pressure.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: This invention is a process for making 1,2-propane diol from glycerol. The process comprises subjecting a glycerol stream to hydrogenation conditions in the presence of a transition metal promoted skeletal copper catalyst to enhance selective production of 1,2-propane diol product. Chromium promoted catalyst is preferred for this invention, and moreover, it is preferred that the skeletal copper catalyst is prepared from copper aluminum alloys that have been subjected to leaching conditions selected to achieve at least 40% leaching of aluminum from the alloy. This process is particularly conducive to conducting the hydrogenation with reactant mixture in the liquid phase. The catalysts used in this invention are particularly suitable for use in a fixed catalyst bed, but can be activated and sized so that the catalyst is also suitable for use in slurry based reactions.

Abstract: A method of boresighting includes providing a weapon including a bore having a centerline axis and a boresight telescope coupled into the bore. The boresight telescope has a beam splitter therein which directs image information received from an aiming reference to an eyepiece of the boresight telescope which is off-axis relative to the centerline axis. A boresight camera accessory (BCA) is removably coupled to the eyepiece. The BCA includes an objective and a photodetector array, wherein the objective focuses the image information from the eyepiece to the photodetector array which generates sensing signals. The sensing signals are automatically transmitted to at least one remote viewer, and a viewable image of the aiming reference is displayed from the sensing signals. The remote viewer individually boresights the weapon using the viewable image and a view of the aiming reference through the bore.

Abstract: A fuel injector assembly is provided herein. The fuel injector assembly includes an insulated delivery conduit in fluidic communication with a fuel pump and a conductive enclosure at least partially surrounding the insulated delivery conduit. The fuel injector assembly further includes a seal positioned between the insulated delivery conduit, conductive enclosure, and the fuel injector outlet with radial and axial forces against an exterior surface of the insulated delivery conduit, interior surface of the conductive enclosure, and the exterior surface of fuel injector outlet.

Abstract: A stem or adapter for boresighting weapons includes a first portion having a weapon insertion end including a centering device including a plurality of fingers which compress upon insertion into a bore of a weapon. A second portion has a first end attached to an end of the first portion opposite to the weapon insertion end. The second portion has a coupling end including an attachment feature opposite the first end for attaching another member thereto. The second portion is largely tungsten carbide, and the first portion is formed from a material that is largely not tungsten carbide to provide sufficient flexibility to allow the fingers to spring load when inserted into the bore of the weapon.

Abstract: An insertion device for inserting an infusion device at least partially into skin for subcutaneous infusion can comprise a sleeve having a lower surface that is configured to engage the skin, a shuttle or carriage to carry the infusion device between a retracted position and an advanced position; at least a first biasing member to urge the shuttle or carriage toward the advanced position, and an actuator to cause the first biasing member to urge the carriage from the retracted position to the advanced position. In some embodiments, the insertion device can further comprise a hub and at least a second biasing member to urge the hub away from the shuttle or carriage. In some embodiments, the insertion device can further comprise a needle attached to the hub. Methods for inserting an infusion device and various other features that can be comprised by an insertion device are also disclosed.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: A process for the manufacture of a powder coating comprising the steps of: Preparing a powder coating premix comprising a resin and optionally a crosslinker therefor; Feeding the premix through a melt extruder; Cooling the extruded material; and Comminuting it to fine particles, wherein said process is characterized in that between 1 and 25 wt. % (based on the weight of said premix) of a process liquid is added to the melt extruder, wherein said process liquid is immiscible with at least said resin of the powder coating premix and wherein said process liquid evaporates when the premix leaves the extruder.

Abstract: The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: A health monitoring device that includes a data logger module that collects health information from a subject or clinician during specific time ranges that are part of a health monitoring schedule. The collected health information and/or the time ranges are determined in part by the content of the collected health information. The device records the collected health information along with a time stamp. The device also includes a clock and a time shift mode that allows a user to adjust the clock to a specified point in the health monitoring schedule so that the device operates at the specified point in the same manner as if the device had reached the specified point without intervention by the user to adjust the clock.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: Protective equipment for the limbs including a front guard, wherein the front guard includes support means attached to the front guard, a front surface, and a plurality of teeth protruding from the front surface for assisting a user in climbing over an obstacle, wherein the teeth include at least one engagement surface arranged to at least partially engage with a surface of the obstacle when pressure is applied to the support means.

Abstract: This invention is a process for making 1,2-propane diol from glycerol. The process comprises subjecting a glycerol stream to hydrogenation conditions in the presence of a transition metal promoted skeletal copper catalyst to enhance selective production of 1,2-propane diol product. Chromium promoted catalyst is preferred for this invention, and moreover, it is preferred that the skeletal copper catalyst is prepared from copper aluminum alloys that have been subjected to leaching conditions selected to achieve at least 40% leaching of aluminum from the alloy. This process is particularly conducive to conducting the hydrogenation with reactant mixture in the liquid phase. The catalysts used in this invention are particularly suitable for use in a fixed catalyst bed, but can be activated and sized so that the catalyst is also suitable for use in slurry based reactions.

Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.