Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: An apparatus for use in a well borehole packing operation takes the form of a downhole packer and comprises a body and a seal member. In use, the apparatus is run into a borehole as part of a downhole completion assembly. On reaching the desired location, the apparatus is activated to urge the seal member into sealing engagement with the borehole, and thereby isolate an annular region between the apparatus and the borehole. A conduit is disposed within the body and is offset from a central longitudinal axis of the apparatus, the conduit configured to transport a borehole packing material, such as gravel slurry, through the apparatus.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: A screen assembly, such as a downhole/sand screen assembly, comprising first and second screen portions or screens longitudinally coupled together, wherein there is provided a fluid flow path between the first and second screen portions or screen. Optionally, the first and second sleeves are coupled or connected by a centraliser or further sleeve or screen, and/or optionally by or via first and second support ring.

Abstract: An anchoring apparatus for use in a wellbore, comprises at least one movable wall engaging member for engaging a wall of a wellbore, wherein the at least one movable wall engaging member is movable from a retracted position to an expanded position to engage the wall, and from the expanded position to a retracted position to disengage the wall. Provision of one or more wall engaging members being movable from an expanded position to a retracted position allows the anchoring apparatus to be retrieved from the wellbore, and in particular, from an open hole.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: An anchoring apparatus for use in a wellbore, comprises at least one movable wall engaging member for engaging a wall of a wellbore, wherein the at least one movable wall engaging member is movable from a retracted position to an expanded position to engage the wall, and from the expanded position to a retracted position to disengage the wall. Provision of one or more wall engaging members being movable from an expanded position to a retracted position allows the anchoring apparatus to be retrieved from the wellbore, and in particular, from an open hole.

Abstract: Downhole apparatus is provided for location in a fluid-filled bore, such as a well bore. The apparatus comprises a tubular body comprising a plurality of cylindrical chambers for containing a compressible substance, and pistons mounted in the chambers. A lock arrangement is provided and has a locking configuration for retaining the pistons in the chambers and an unlocked configuration in which bore fluid pressure may translate the pistons through the chambers.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: The present invention involves the preparation and manufacture of phenolic insulation boards for use in double-walled ductwork systems. The preparation of the phenolic insulation board, having a first and second surface each having a foil coating, includes the cutting or grooving of V-grooves into the first surface of the phenolic insulation and first foil coating. This grooving process creates a continuous piece of phenolic insulation having trapezoidal shapes along the second surface and second foil coating. The prepared phenolic insulation board can then be wrapped around an inner sheet metal duct and then covered with an outer shell. Alternatively, the prepared phenolic insulation board can be inserted between an inner duct and outer shell. Both result in a double-walled phenolic insulation ductwork systems.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: A downhole apparatus comprises a piston mounted within a bore and being reconfigurable from a lock configuration to an unlock configuration in response to a pressure sequence applied within the bore. When the piston is in its lock configuration, a lock is supported by the piston such that the lock partially extends into the bore and engages a lock profile of the piston to restrict movement of the piston in a first direction towards its unlock configuration. In response to a first event of the pressure sequence, the piston is moveable in a second direction to desupport the lock and permit the lock to be wholly received into the bore and allow the piston to move in the second direction towards its unlock configuration in response to a subsequent event of the pressure sequence.

Abstract: A downhole fluid control apparatus comprises first and second conduits for providing communication between a pressure source and a downhole device, and a valve provided within a housing and configurable between a first configuration in which the first and second conduits are in pressure communication via the valve, and a second configuration in which the first and second conduits are isolated from each other. The apparatus further comprises an actuator for operating the valve. The actuator is in pressure communication with the first and second conduits and with an ambient region external of the apparatus such that when the pressure within each of the first and second conduits is lower than the ambient pressure the valve is configured in its first configuration, and when the pressure within at least one of the first and second conduits exceeds the ambient pressure the valve is configured in its second configuration.

Abstract: A screen assembly, such as a downhole/sand screen assembly, comprising first and second screen portions or screens longitudinally coupled together, wherein there is provided a fluid flow path between the first and second screen portions or screen. Optionally, the first and second sleeves are coupled or connected by a centraliser or further sleeve or screen, and/or optionally by or via first and second support ring.

Abstract: A flow restrictor for restricting flow in an annulus, the flow restrictor comprising a body and a restrictor assembly mounted on the body, wherein the restrictor assembly is actuatable between a run-in configuration and a set configuration in which at least a portion of the restrictor assembly is radially splayed to thereby substantially restrict flow in the annulus, and wherein the flow restrictor is actuatable by fluid flow over the restrictor assembly above a threshold flow rate to actuate the restrictor assembly from the run-in configuration to the set configuration.

Abstract: An anchoring apparatus for use in a wellbore, comprises at least one movable wall engaging member for engaging a wall of a wellbore, wherein the at least one movable wall engaging member is movable from a retracted position to an expanded position to engage the wall, and from the expanded position to a retracted position to disengage the wall. Provision of one or more wall engaging members being movable from an expanded position to a retracted position allows the anchoring apparatus to be retrieved from the wellbore, and in particular, from an open hole.

Abstract: Downhole apparatus is provided for location in a fluid-filled bore, such as a well bore. The apparatus comprises a tubular body comprising a plurality of cylindrical chambers for containing a compressible substance, and pistons mounted in the chambers. A lock arrangement is provided and has a locking configuration for retaining the pistons in the chambers and an unlocked configuration in which bore fluid pressure may translate the pistons through the chambers.

Abstract: An anchoring apparatus (110) for use in a wellbore, comprises at least one movable wall engaging member (120) for engaging a wall of a wellbore, wherein the at least one movable wall engaging member (120) is movable from a retracted position to an expanded position to engage the wall, and from the expanded position to a retracted position to disengage the wall. Provision of one or more wall engaging members (120) being movable from an expanded position to a retracted position allows the anchoring apparatus to be retrieved from the wellbore, and in particular, from an open hole.