Abstract: The present application relates to systems and methods for use in wellbore completion. Embodiments of the invention relate to a method and system for operating a downhole tool, such as a downhole tool associated with well fracturing.

Abstract: Completing a wellbore in a subsurface formation with packer assembly having first mechanically-set packer as first zonal isolation tool, and second zonal isolation tool comprises internal bore for receiving production fluids, and alternate flow channels. First packer has alternate flow channels around inner mandrel, and sealing element external to inner mandrel and includes operatively connecting packer assembly to a sand screen, and running into wellbore. First packer set by actuating sealing element into engagement with surrounding open-hole portion of the wellbore. Thereafter, injecting a gravel slurry and further injecting the gravel slurry through the alternate flow channels to allow it to bypass the sealing element, resulting in a gravel packed wellbore within an annular region between sand screen and surrounding formation below packer assembly.

Abstract: Method for completing a wellbore in a subsurface formation includes providing a sand control device representing one or more joints of sand screens, and a packer assembly along the joints with at least one mechanically-set packer with at least one alternate flow channel therein. Running the packer assembly and connected sand screen into the wellbore, setting a mechanically-set packer into engagement with the surrounding wellbore, injecting gravel slurry into the wellbore to form a gravel pack. An elongated isolation string is run into the sand control device across the packer assembly with valves that serve as an inflow control device. Thereafter, seals are activated around the isolation string and adjacent the packer assembly. A zonal isolation apparatus allows flow control to be provided above and below packer assembly.

Abstract: Apparatus and method for completing a wellbore including providing a packer having an inner mandrel, alternate flow channels along the inner mandrel, and a sealing element external to the inner mandrel, including connecting packer to tubular body, then running the packer and connected tubular body into the wellbore. In one aspect, the packer and connected tubular body may be placed along an open-hole portion of the wellbore. Tubular body may be a sand screen, with the sand screen comprising a base pipe, a surrounding filter medium, and alternate flow channels. The method includes setting a packer and injecting a gravel slurry into an annular region formed between the tubular body and the surrounding wellbore, and then further injecting the gravel slurry through the alternate flow channels to allow the gravel slurry to at least partially bypass sealing element of the packer.

Abstract: A computer implemented method, apparatus, and computer program product for managing aircraft software parts. An aircraft software part is received at a library. The received part is stored in the library with other aircraft software parts. A user interface is provided to manipulate the aircraft software parts. Responsive to receiving a user input from the user interface to uplink a selected aircraft software part to a target aircraft data processing system, a command is created to send the selected part to an aircraft in which the target aircraft data processing system is located. The uplink command is stored in a queue in the storage in the library. The uplink command is distributed to a proxy server application in response to a request for commands. Responsive to receiving a request from the proxy server application processing the stored uplink command, the selected part is sent to the proxy server application.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: The present invention provides methods of preventing, decreasing, or inhibiting the degradation of cationic lipids and/or active agents (e.g., therapeutic nucleic acids) present in lipid particles, compositions comprising lipid particles stabilized by these methods, methods of making these lipid particles, and methods of delivering and/or administering these lipid particles, e.g., for the treatment of a disease or disorder.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: Methods and apparatus for use in communicating between a vehicle and a remote application server. An application message is received from a vehicle. A computer system determines whether an uplink connection can be established between the computer system and a remote application server that provides a remote software application associated with the application message. The application message is redirected to a local software application executed by the computer system when an uplink connection cannot be established. Data may be subsequently synchronized between the local software application and the remote software application.

Abstract: A lock ring for use as a one way movement restrictor between two telescopingly arranged tubulars to permit movement in one direction and prevent movement in the other direction of one tubular relative to the other tubular is described. The lock ring comprised: a profile having one or more formations formed on the outer circumference for engagement with a suitable formation profile formed on the inner circumference of the outer telescopic tubular; and one or more teeth formed on its inner circumference, the teeth being adapted to dig into the outer surface of the inner telescopic member. An apparatus and a method for setting a downhole anchor is also disclosed.

Abstract: The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

Abstract: The technology of the present application provides a system and method for marking opposing surfaces of varying sizes, shapes, and materials. This system and method allow a user to transfer the outline or location of a relevant feature such as, for example, a fastener, utility outlet, architectural feature, or window or door, from one surface to another through the use of a transferable marking substance, thereby eliminating the need for complicated and limited fixtures or time consuming and often inaccurate manual measurements.

Abstract: The invention is to enable quick keyboard input for practically any sized device through the use of two primary multi-direction inputs. By pressing two multi-direction inputs, each in a direction, the user enters an alphanumeric character. Existing patents (U.S. Pat. Nos. 6,590,566, 7,171,498, 7,417,566) require larger, slower interfaces or aren't as user friendly.

Abstract: A computer implemented method, apparatus, and computer program product for managing aircraft software parts. An aircraft software part is received at a library. The received part is stored in the library with other aircraft software parts. A user interface is provided to manipulate the aircraft software parts. Responsive to receiving a user input from the user interface to uplink a selected aircraft software part to a target aircraft data processing system, a command is created to send the selected part to an aircraft in which the target aircraft data processing system is located. The uplink command is stored in a queue in the storage in the library. The uplink command is distributed to a proxy server application in response to a request for commands. Responsive to receiving a request from the proxy server application processing the stored uplink command, the selected part is sent to the proxy server application.

Abstract: A computer implemented method and apparatus for managing aircraft software parts. An aircraft software part management apparatus comprises a library, a receiving module, a proxy server, an onboard electronic distribution system on an aircraft, and a portable software maintenance tool. The library on the ground data processing system stores and manages aircraft software parts for aircraft. The receiving module is capable of receiving the aircraft software parts from suppliers and sending the aircraft software parts to the library. The proxy server is in communication with the library and is capable of distributing software to a plurality of aircraft clients. The onboard electronic distribution system is an aircraft client and is capable of receiving aircraft software parts for the aircraft from the library through the proxy server. The portable software maintenance tool provides an alternate route to send the aircraft software part to the onboard electronic distribution system for the aircraft.

Abstract: The technology of the present application provides a system and method for marking opposing surfaces of varying sizes, shapes, and materials. This system and method allow a user to transfer the outline or location of a relevant feature such as, for example, a fastener, utility outlet, architectural feature, or window or door, from one surface to another through the use of a transferable marking substance, thereby eliminating the need for complicated and limited fixtures or time consuming and often inaccurate manual measurements.

Abstract: The present invention provides an apparatus (10) and method for transmitting torque to a downhole device. The apparatus (10) comprises a first part and a second part adapted for connection to the downhole device. The apparatus (10) also comprises an engagement means (100, 120). The first and second parts are connected together such that relative axial movement between the first and second parts is constrained on a helical path. The engagement means (100, 120) are arranged to rotationally connect the first and second parts to thereby transmit torque from the first part to the second part when a coupling point is reached on the helical path.

Abstract: A method and apparatus for use with two or more hydraulic conduits deployed downhole reduces a number of penetrations required through a well bulkhead for a given number of fluid paths extending therethrough. In a described embodiment, a fluid conductor includes multiple fluid paths extending therein. The fluid conductor is installed in an aperture formed through a bulkhead. Couplings are connected on opposite sides of the bulkhead to opposite ends of the fluid conductor. Multiple hydraulic lines are connected to each of the couplings.

Abstract: In accordance with the invention, a liquid sample for thermal analysis is disposed within a receptacle having a bottom surface and side walls. The top edges of the side walls are bent towards the center of the receptacle. A sheet of flexible, transparent material substantially impermeable to the sample is disposed across the top edges of the side walls, and an open lid compresses an o-ring onto the sheet material, sealing it against the bent top edges of the receptacle. The bottom surface of the receptacle is advantageously coated with a a material not wetted by the sample such as a fluorcarbon.

Abstract: An apparatus for measuring thermomechanical properties of a photo-sensitive material sample during exposure of the sample material to a light source includes a sample holder having a sample support positionable in a sample holding area of the sample holder for holding the photo-sensitive material sample, a probe disposable relative to the sample support for measuring the thermomechanical properties of the photo-sensitive material sample, a temperature control unit having a cavity for receiving the sample holder and for maintaining the sample holder within a selectively-controlled temperature range, and an illuminating assembly operatively arranged for directing a light signal onto the sample holder for illuminating the photo-sensitive material held on the sample holder.