Abstract: Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

Abstract: A process for producing a heat-sealable polymeric film comprises the steps of: (a) melt-extruding a substrate layer of polymeric material; (b) stretching the substrate layer in a first direction; (c) optionally stretching the substrate layer in a second, orthogonal direction; (d) optionally heat-setting the stretched substrate layer; (e) forming a heat-sealable coating layer on a surface of the substrate layer by melt-coating directly thereon a molten polymeric material; and (f) cooling the coated substrate layer; wherein coating step (e) is prior to step (b) or between steps (b) and (c); wherein the thickness of the coating layer is less than about 8 ?m; wherein the molten polymeric material of the coating layer comprises a copolyester, and wherein the molten polymeric material comprises a copolyester.

Abstract: The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Abstract: According to the invention, there is provided a hybrid maize plant, designated as 33N09, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. This invention relates to the hybrid seed 33N09, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 33N09. This invention also relates to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by those methods. This invention further relates to methods for producing maize lines derived from hybrid maize line 33N09 and to the maize lines derived by the use of those methods.

Abstract: The present invention describes a method for detecting biomolecular interactions said method comprising: (a) selecting an appropriate reporter molecule selected from the group consisting of a protein, a fluorescent protein, a luminescent protein and a phosphorescent protein; (b) effecting fragmentation of said reporter molecule such that said fragmentation results in reversible loss of reporter function; (c) fusing or attaching fragments of said reporter molecule separately to other molecules; followed by (d) reassociation of said reporter fragments through interactions of the molecules that are fused to said fragments; and (e) detecting said biomolecular interactions by reconstitution of activity of the reporter molecule with the proviso that said protein is not ubiquitin.

Abstract: The invention provides CD3 specific binding molecules and nucleic acid sequences encoding said CD3 specific binding molecules. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and compositions comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

Abstract: This invention provides methods of protein/polypeptide screening based on the provision of libraries of individual proteins/polypeptides, which in turn can be screened for a number of activities, including cell binding and biological activity. Methods for recovering genes encoding such proteins/polypeptides are also provided.

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract: A process for activating a cobalt-containing catalyst by contacting the catalyst with hydrogen in a reaction system suitable for use in a Fischer-Tropsch synthesis wherein a first gaseous stream comprising 0.25 to 5% by volume of hydrogen and 95 to 99.75% by volume of inert gas is continuously introduced into the reaction system and a second gaseous stream is continuously withdrawn from the reactor system wherein the activation procedure comprises the steps of: (A) heating the contents of the reactor system to a temperature which is in a range of 25 to 5° C. below a critical activation temperature; (B) thereafter increasing the temperature at a rate of up to 20° C. per hour to a first hold temperature which is in a range of from the critical activation temperature to a temperature which is at most 20° C. above the critical activation temperature; and (C) maintaining the contents of the reactor system approaches the hydrogen content of the first gaseous stream.

Abstract: A receiver for a direct sequence spread spectrum signal subject to interference from a locally transmitted or received frequency-hopped spread spectrum signal includes a programmable notch filter which is controlled in accordance with the code sequence of a frequency-hopped signal to reject frequencies corresponding to those producing interference

Abstract: The present invention is directed to methods for identifying one or more analytes in a sample using electrophoresis. In one embodiment, the method comprises performing an electrophoretic separation by applying a potential across the separation path and thus generating a current and power therein and producing an electropherogram, integrating the current or the power to determine the cumulative current or power as a function of the separation time, transforming the electropherogram to a second electropherogram representing the signal as a function of the cumulative current or power, and identifying in the second electropherogram peaks that are correlated with the analytes in the sample. The invention also provides systems for performing the analysis and identification methods, as well as computer-readable products for performing the steps associated with the above methods.

Abstract: The present invention describes a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. It allows for the screening of a protein library against a second protein library, rather than against a single bait protein, and thus has numerous applications in the study of protein-protein interactions. Additionally, it allows for the application of different selection stringencies. Two leucine zipper libraries, semi-randomized at the positions adjacent to the hydrophobic core, were genetically fused to either one of two designed fragments of the enzyme murine dihydrofolate reductase (mDHFR), and cotransformed into E. coli. Interaction between the library polypeptides was required for reconstitution of the enzymatic activity of mDHFR, allowing bacterial growth.

Abstract: A method and system for memory page protection wherein new stack memory load/store instructions are defined for memory management. A corresponding operating system and compiler utilize these new stack memory load/store instructions. Whenever it is desired to have a block of memory used as a stack memory, the stack memory load/store instructions are used. A stack memory attribute is stored in a page table associated with the block of memory. Memory blocks having a stack memory attribute may be read and written into using only stack memory load/store instructions. If a normal load/store is attempted to a memory block having a stack memory attribute a error condition is indicated. Likewise a stack memory load/store to a block of memory not have a stack memory attribute will cause a error condition. Stack memory load/stores meant for one type of stack memory (e.g., program stack attribute) will also cause a fault if the stack load/store is attempted to another type of stack memory (e.g., processor stack).

Abstract: The invention relates to a method for the transmission of messages by using a message service to a recipient who uses at least a primary mobile station (3), in which there is at least the possibility to receive calls and messages, and at least one secondary mobile station (4, 4?), in which there is at least the possibility to receive messages. The messages addressed to the primary mobile station (3) can be directed to any of the secondary mobile stations (4, 4?) of the recipient, irrespective of calls.

Abstract: A balancer assembly 10 which automatically provides balancer limits, which achieves a balancing state while substantially minimizing short term vibration increases and which provides for multi-plane balancer dithering.

Abstract: In the context of a DVD-RAM read-type architecture in which an optical storage medium (20) makes use of an eccentric wobble (164) to attain synchronisation information, a wobble PLL (179) is held in an acquired state whenever header regions (32, 33) embossed at regular intervals across the optical storage medium (20) are detected. More specifically, large dc variations associated with voltage spikes caused by header regions (32, 33) are scaled (260) relative to a dynamically varying amplitude envelope of the extracted wobble signal (164), such as to identify a start location (300) for each header region. The wobble PLL (179) is effectively allowed to free-run and hold state during periods of header, thereby mitigating the likelihood that the wobble PLL will loose lock during the header regions.

Abstract: A tamper-evident container comprises a body portion (2), a lid portion (4) adapted to engage and close said body portion (2), and at least one tamper-evident element (14) releasably attached to one of said portions (4) by a weakened connection (16), and having an operative position co-operating with means on the other of said portions (2) to prevent removal of the lid portion (4) from the body portion (2), the lid portion (4) only being removable from the body portion (2) subsequent to breakage of the weakened connection (16) between the or each tamper-evident element (14) and the one portion (4) of the container, the or each tamper evident element (14), on breakage, having a displaced position on the other portion (2) of the container providing a visual indication that tampering may have occurred, and the container incorporating means to retain the or each tamper-evident element (14) in its displaced position on the other portion (2) of the container such that removal of the or each tamper-evident element (1

Abstract: A CD20-binding polypeptide composition of the invention comprises at least one polypeptide selected from the group consisting of a polypeptide having the amino acid residue sequence of SEQ ID NO: 1 (Vh of 2B8 antibody), but which includes at least one amino acid residue substitution in SEQ ID NO: 1 selected from the group consisting of V12K, A14P, M20V, I48T, A68T, Q82E, T87R, S91T, and T106W; a polypeptide having the amino acid residue sequence of SEQ ID NO: 4 (Vk of 2B8 antibody), but which includes at least one amino acid residue substitution in SEQ ID NO: 4 selected from the group consisting of L11I, S12T, S27T, V29A, G40T, V59S, S69T, L72M, R76S, and V77L; a polypeptide having the amino acid residue sequence of SEQ ID NO: 9 (Vh of Leu16 antibody), but which includes at least one amino acid residue substitution in SEQ ID NO: 9 selected from the group consisting of V12K, M20V, A68T, Q82E, T87R, S91T, D93V, and A114T; and a polypeptide having the amino acid residue sequence of SEQ ID NO: 11 (Vk of Leu16 ant

Abstract: Protein Fragment Complementation Assays (PCA) are done in plant material using enzyme fragment constructs, for example, dihydrofolate reductase (DHFR) fragment constructs. Plant material is transformed with at least two different constructs that form different products capable of interacting to reconstitute enzymatic activity in the plant material. Detection of the activity can be done using a substrate for the enzyme in the culture medium which, when reacted with the enzyme, is converted to a detectable product. One embodiment uses a substrate that can be enzymatically converted to a detectable fluorescent product. An inducer such as rapamycin or salicylic acid can be added to the culture medium to increase the level of detectable product.

Abstract: A roller skate having enhanced steerability and stability is disclosed. The skate includes a platform for supporting a skater's foot and front and rear wheel trucks secured to the underside of the platform. A pair of front wheels is rotatably mounted in transverse axial alignment on the front wheel truck and a pair of rear wheels is rotatably mounted in transverse axial alignment on said rear wheel truck. The pairs of front and rear wheels are also in parallel axial alignment with each other and mounted on their respective wheel trucks for resiliently controlled, tilting movement about downwardly inclined longitudinal axes. In addition, a fifth wheel is rotatably mounted on the front wheel truck between the pairs of front and rear wheels and in parallel axial alignment with the wheel pairs.