Abstract: The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human brain-derived neutrophic factor (BDNF) to result in BDNF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human obesity protein (leptin) to result in leptin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

Abstract: In a multi-regime continuously variable ratio transmission system, the clutch (H) of a new regime is applied substantially instantaneously in a synchronous mode of the transmission to allow the clutch engagement to be based on the actual, rather than the predicted, ratio of the transmission. The transmission system is under the control of a control system applying clutch apply pressure and controlling the setting of the variator forming part of the transmission system, the control of the clutch apply pressure being carried out independently of the control of the variator such that the settings of the variator are unaffected by the variations in the clutch apply pressures.

Abstract: A process for producing a heat-sealable polymeric film, particularly a heat-sealable peelable polymeric film, comprising the steps of: (a) melt-extruding a substrate layer of polymeric material; (b) stretching the substrate layer in a first direction; (c) optionally stretching the substrate layer in a second, orthogonal direction; (d) optionally heat-setting the stretched film; (e) forming a heat-sealable coating layer on a surface of the substrate by melt-coating directly thereon a molten polymeric material; and (f) cooling the coated substrate, wherein coating step (e) is prior to step (b) or between steps (b) and (c); wherein the thickness of the coating layer is less than about 8 ?m; wherein the molten polymeric material of the coating layer comprises a copolyester, and wherein said process optionally further comprises the step of adding water to the polymeric material of the coating layer prior to the coating step, wherein said water is added in an amount in the range of from about 600 ppm to about

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The inention in particular relates to the modification of erythropoietin (EPO) to result in erythropoietin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

Abstract: A flow probe for use in a humidification system is disclosed. The flow probe is adapted to be positioned in a humidified gases flow (for example oxygen or anaesthetic gases) such as that which is provided to a patient in a hospital environment. The flow probe is designed to provide both temperature and flow rate sensing of the gases flow by incorporating two sensors (preferably thermistors) and the shape and alignment of the probe enables accurate readings by reducing the occurrence of condensation on the sensors.

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of keratinocyte growth factor (KGF) to result in keratinocyte growth factor (KGF) proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of granulocyte colony stimulating factor (G-CSF) to result in granulocyte colony stimulating factor (G-CSF) proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

Abstract: A polymeric material comprises at least one repeat unit consisting substantially of a moiety of Formula 1: 1

Abstract: A method for preparing an organosilicon composition from an olefin and a silicon hydride with a hydrosilation catalyst PtL2X2, in an amount less than 1 ppm based on the weight of the product composition, is disclosed. The method is particularly useful in lowering the cost, coloration, and stability of the product, particularly when an oxirane-containing olefin is used in the hydrosilation. In this method no inhibitor is needed to prevent the undesired polymerization of oxiranes in the reaction, and no purification of the product is required after removal of volatile components, including solvent.

Abstract: A system and method for predicting cylinder air charge in an internal combustion engine for a future cylinder event is provided. The pressure in an intake manifold is calculated and an estimated position for a throttle plate of the engine at least one cylinder event in the future is determined responsive to an electronic throttle control command. A rate of change of pressure in the intake manifold is then estimated responsive to the measured intake manifold pressure and the estimated throttle plate position. The cylinder air charge is then calculated responsive to the rate of change in pressure in the intake manifold.

Abstract: The roll forming machine comprise a series of rollers 14, 20, 28 and 36 for shaping a fabric 13 such as a fabric impregnated with a curable matrix. A feed roller 36 is provided for feeding a length of material 37 such as a tow of fibres onto the fabric during or subsequent to the shaping process. The roll forming process is particularly useful in the manufacture of blade stiffeners for an aircraft wing.

Abstract: We describe a strategy for designing and implementing protein-fragment complementation assays (PCAs) to detect biomolecular interactions in vivo and in vitro. The design, implementation and broad applications of this strategy are illustrated with a large number of enzymes with particular detail provided for the example of murine dihydrofolate reductase (DHFR). Fusion peptides consisting of N- and C-terminal fragments of murine DHFR fused to GCN4 leucine zipper sequences were coexpressed in Escherichia coli grown in minimal medium, where the endogenous DHFR activity was inhibited with trimethoprim. Coexpression of the complementary fusion products restored colony formation. Survival only occurred when both DHFR fragments were present and contained leucine-zipper forming sequences, demonstrating that reconstitution of enzyme activity requires assistance of leucine zipper formation. DHFR fragment-interface point mutants of increasing severity (Ile to Val, Ala and Gly) resulted in a sequential increase in E.

Abstract: A field effect transistor in which a continuous semiconductor layer comprises:

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: There are described solid procatalysts, catalyst systems incorporating the solid procatalysts, and the use of the catalyst systems in olefin polymerization and interpolymerization.

Abstract: A flow probe for use in a humidification system is disclosed. The flow probe is adapted to be positioned in a humidified gases flow (for example oxygen or anaesthetic gases) such as that which is provided to a patient in a hospital environment. The flow probe is designed to provide both temperature and flow rate sensing of the gases flow by incorporating two sensors (preferably thermistors) and the shape and alignment of the probe enables accurate readings by reducing the occurrence of condensation on the sensors.

Abstract: A method and apparatus for obtaining information from a utility meter. A digital camera is used to take a digital image of information displayed on the utility meter. The digital image is passed to a computer that is arranged to extract information displayed on the utility meter from the image. The information may be used for a variety of purposes such as updating databases with details of utility meters and for billing purposes.