Patents by Inventor Stephen Zhou

Stephen Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220205017
    Abstract: Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information.
    Type: Application
    Filed: May 19, 2020
    Publication date: June 30, 2022
    Inventors: Anthony SCHMITT, Siddarth SELVARAJ, Bret REID, Stephen MAC, Xiang ZHOU
  • Publication number: 20220195007
    Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have enhanced antitumor properties and/or can be regulated by safety switches. Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a cancer in a subject are also provided.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 23, 2022
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Mireya Paulina VELASQUEZ, Stephen GOTTSCHALK, Janice RIBERDY, Albert ZHOU, Byoung RYU, Abishek VAIDYA, Giedre KRENCIUTE
  • Publication number: 20220180763
    Abstract: Systems and methods are provided for feedback-driven provision of information in relation to a plurality of information resources.
    Type: Application
    Filed: November 11, 2021
    Publication date: June 9, 2022
    Inventors: Jugoslav BILIC, Ivana BILIC, Justin CALLISON, Manuj AGGARWAL, Stephen MICHAUD, Ryan OGG, Juan Camilo RAMIREZ, Sarbjit SARKARIA, Jian ZHOU
  • Publication number: 20220161055
    Abstract: The present disclosure relates to using a light signal (e.g., an infrared (IR) light signal) for long-term modulation of peripheral nerve activity. Light generated with parameters (including intensity and time) can be applied to a peripheral nerve to achieve a target biological response. The target biological response can extend for a period after the light is applied. For example, when the light is applied for short period of time (e.g., 20 seconds), the target biological response can extend for a long period of time (e.g., over one hour).
    Type: Application
    Filed: February 8, 2022
    Publication date: May 26, 2022
    Inventors: Michael W. JENKINS, Stephen J. LEWIS, Hillel J. CHIEL, Eric Duco JANSEN, Junqi ZHOU, Emilie LOTHET, Gjinovefa KOLA
  • Publication number: 20220152750
    Abstract: An apparatus, material and method for forming a reliably roll-bonded, multi-layer aluminum alloy brazing sheet has a core of 2XXX, 3XXX, 5XXX or 6XXX alloy, a braze liner of 4XXX alloy and an interliner with Mn in the range of 0.2 to 1.0 wt. % and Si in the range of 0.31-1.0 wt. %. Alternatively, Mg in the range of 0.1 to 0.5 wt. % may be present in the interliner. Additional layers such as a second braze liner may be present for providing an inner surface of a heat exchanger. An additional interliner may optionally be used between the core the inner surface layer. The material may be used for highly corrosive environments like an EGR cooler.
    Type: Application
    Filed: April 24, 2019
    Publication date: May 19, 2022
    Inventors: Tao ZHOU, Stephen F. BAUMANN, Baolute REN
  • Publication number: 20210153311
    Abstract: An emergency lighting system uses a wireless mesh network to control the dimming of luminaires in the event of a power failure or a power outage. Luminaires are commissioned to different dimming power levels depending on localized lighting needs during the power failure of power outage.
    Type: Application
    Filed: November 18, 2020
    Publication date: May 20, 2021
    Applicant: McWong Inc.
    Inventors: Blane Goettle, Stephen Zhou, Michael Darren Musgrove, Stan Ouyang
  • Patent number: 10279547
    Abstract: The present invention in one or more embodiments provides a method of forming an opening on a panel, the method including pressing in a first direction on the panel to form a protrusion with a tip portion, and cutting the protrusion with a force in a second direction to remove the tip portion to form the opening on the panel, the second direction being different from the first direction. The first direction may be a direction of gravity plus and minus up to 15 degrees. The second direction may be transverse to the first direction with an angle differential there-between of 75 to 105 degrees.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 7, 2019
    Assignee: Ford Global Technologies, LLC
    Inventors: Tom Xu, Gary D. Mullen, Peter Zhang, Stephen Zhou, Frank Hu
  • Publication number: 20180291090
    Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 11, 2018
    Applicant: GENENTECH, INC.
    Inventors: Sek Chung Fung, Kang Li, Yucheng Li, Sanjaya Singh, Bin-Bing Stephen Zhou
  • Publication number: 20170014526
    Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: July 27, 2016
    Publication date: January 19, 2017
    Applicant: Pfizer Inc.
    Inventors: Kenneth G. Geles, Yijie Gao, Puja Sapra, Lioudmila Gennadievna Tchistiakova, Bin-Bing Stephen Zhou
  • Patent number: 9518124
    Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: December 13, 2016
    Assignee: Genentech, Inc.
    Inventors: Kang Li, Bin-Bing Stephen Zhou, Wenjuan Wu, Sek Chung Fung, Sanjaya Singh
  • Patent number: 9433687
    Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: September 6, 2016
    Assignee: Pfizer Inc.
    Inventors: Kenneth G. Geles, Yijie Gao, Puja Sapra, Lioudmila Gennadievna Tchistiakova, Bin-Bing Stephen Zhou
  • Publication number: 20160052213
    Abstract: The present invention in one or more embodiments provides a method of forming an opening on a panel, the method including pressing in a first direction on the panel to form a protrusion with a tip portion, and cutting the protrusion with a force in a second direction to remove the tip portion to form the opening on the panel, the second direction being different from the first direction. The first direction may be a direction of gravity plus and minus up to 15 degrees. The second direction may be transverse to the first direction with an angle differential there-between of 75 to 105 degrees.
    Type: Application
    Filed: July 23, 2015
    Publication date: February 25, 2016
    Inventors: TOM XU, GARY D. MULLEN, PETER ZHANG, STEPHEN ZHOU, FRANK HU
  • Publication number: 20160002331
    Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 7, 2016
    Applicant: WYETH LLC
    Inventors: Kenneth G. GELES, Bin-Bing Stephen ZHOU, Lioudmila Gennadievna TCHISTIAKOVA, Yijie GAO, Joel BARD
  • Patent number: 9127060
    Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 8, 2015
    Assignee: Wyeth LLC
    Inventors: Kenneth G. Geles, Bin-Bing Stephen Zhou, Lioudmila Gennadievna Tchistiakova, Yijie Gao, Joel Bard
  • Publication number: 20140277438
    Abstract: Ophthalmic devices suitable for implantation into the eye through small incisions or insertion into an existing orifice are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (Tg) of from about ?100° C. to about 37° C., and wherein Tg for the material is lower than Tm for the composition. Disclosed devices include intraocular lenses, corneal inlays, drug delivery devices and implants for reducing intraocular pressure in glaucoma patients.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Medennium, Inc.
    Inventors: Christopher WILCOX, Christine Liau, Stephen Zhou, Igor Valyunin
  • Publication number: 20140127211
    Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 8, 2014
    Applicant: Pfizer Inc.
    Inventors: Kenneth G. Geles, Yijie Gao, Puja Sapra, Lioudmila Gennadievna Tchistiakova, Bin-Bing Stephen Zhou
  • Publication number: 20140093889
    Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Application
    Filed: August 21, 2013
    Publication date: April 3, 2014
    Applicant: Genentech, Inc.
    Inventors: Kang Li, Bin-Bing Stephen Zhou, Wenjuan Wu, Sek Chung Fung, Sanjaya Singh
  • Publication number: 20130266594
    Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.
    Type: Application
    Filed: December 9, 2011
    Publication date: October 10, 2013
    Applicant: Wyeth LLC
    Inventors: Kenneth G. Geles, Bin-Bing Stephen Zhou, Lioudmila Gennadievna Tchistiakova, Yijie Gao, Joel Bard
  • Patent number: 8329868
    Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: December 11, 2012
    Assignee: Genentech, Inc.
    Inventors: Sek Chung Fung, Kang Li, Yucheng Li, Sanjaya Singh, Bin-Bing Stephen Zhou
  • Publication number: 20120213785
    Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 23, 2012
    Applicant: Genentech, Inc.
    Inventors: Kang Li, Bin-Bing Stephen Zhou, Wenjuan Wu, Sek Chung Fung, Sanjaya Singh