Abstract: Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information.

Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have enhanced antitumor properties and/or can be regulated by safety switches. Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a cancer in a subject are also provided.

Abstract: Systems and methods are provided for feedback-driven provision of information in relation to a plurality of information resources.

Abstract: The present disclosure relates to using a light signal (e.g., an infrared (IR) light signal) for long-term modulation of peripheral nerve activity. Light generated with parameters (including intensity and time) can be applied to a peripheral nerve to achieve a target biological response. The target biological response can extend for a period after the light is applied. For example, when the light is applied for short period of time (e.g., 20 seconds), the target biological response can extend for a long period of time (e.g., over one hour).

Abstract: An apparatus, material and method for forming a reliably roll-bonded, multi-layer aluminum alloy brazing sheet has a core of 2XXX, 3XXX, 5XXX or 6XXX alloy, a braze liner of 4XXX alloy and an interliner with Mn in the range of 0.2 to 1.0 wt. % and Si in the range of 0.31-1.0 wt. %. Alternatively, Mg in the range of 0.1 to 0.5 wt. % may be present in the interliner. Additional layers such as a second braze liner may be present for providing an inner surface of a heat exchanger. An additional interliner may optionally be used between the core the inner surface layer. The material may be used for highly corrosive environments like an EGR cooler.

Abstract: An emergency lighting system uses a wireless mesh network to control the dimming of luminaires in the event of a power failure or a power outage. Luminaires are commissioned to different dimming power levels depending on localized lighting needs during the power failure of power outage.

Abstract: The present invention in one or more embodiments provides a method of forming an opening on a panel, the method including pressing in a first direction on the panel to form a protrusion with a tip portion, and cutting the protrusion with a force in a second direction to remove the tip portion to form the opening on the panel, the second direction being different from the first direction. The first direction may be a direction of gravity plus and minus up to 15 degrees. The second direction may be transverse to the first direction with an angle differential there-between of 75 to 105 degrees.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.

Abstract: The present invention in one or more embodiments provides a method of forming an opening on a panel, the method including pressing in a first direction on the panel to form a protrusion with a tip portion, and cutting the protrusion with a force in a second direction to remove the tip portion to form the opening on the panel, the second direction being different from the first direction. The first direction may be a direction of gravity plus and minus up to 15 degrees. The second direction may be transverse to the first direction with an angle differential there-between of 75 to 105 degrees.

Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.

Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.

Abstract: Ophthalmic devices suitable for implantation into the eye through small incisions or insertion into an existing orifice are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (Tg) of from about ?100° C. to about 37° C., and wherein Tg for the material is lower than Tm for the composition. Disclosed devices include intraocular lenses, corneal inlays, drug delivery devices and implants for reducing intraocular pressure in glaucoma patients.

Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.