Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: A television control system and method is proposed. First of all, a first time recording module serves to record time once a television is switched on. Then, a first comparing module serves to compare a result of time recorded by the first time recording module to a first preset time, and send out an actuation signal if the result of time recorded by the first time recording module is longer than the first preset time. Subsequently, a second time recording module serves to record time upon receiving the actuation signal and display a power off message on a display of the television. Finally, a second comparing module serves to compare a result of time recorded by the second time recording module to a second preset time and send out a power off signal to a power off module to switch off power of the television if the result of time recorded by the second time recording module is longer than the second preset time.

Abstract: An ocular plug design and method of insertion is described for the treatment of dry eye. This ocular plug is generally a narrow rod-like cylinder of appropriate diameter, which may be tapered at one end, for insertion into an ocular channel, such as the punctum or the canaliculus. The plug is prepared from a hydrophilic polymeric material which forms a hydrogel upon absorption of water, but is rigid in its nonhydrated form. The plug is hydrated, formed into a length and diameter which is appropriate for insertion into an ocular channel (i.e., it is elongated), and dried so as to become frozen in its elongated state prior to insertion into the ocular channel. Once inserted into the ocular channel, the plug absorbs water, thereby becoming a hydrogel which is soft and pliable, and it expands to adapt to the size and shape of the patient's punctum or canaliculus. Once the plug expands to the size of a particular ocular channel, the plug is met with resistance from the surrounding tissue.

Abstract: Intraocular lenses containing a photochromic agent having its maximum absorption peak in the wavelength range of about 400-500 nm, are disclosed. Methods for making these intraocular lenses are also taught.

Abstract: An accommodative intraocular lens (IOL) and a method of implanting the lens are disclosed. The lens is made from a soft shape memory material and has a first configuration associated with a first diopter power. When the lens is implanted into the capsule in the eye, the interaction between the lens and the capsule, based on their relative sizes, causes the lens to take on a second configuration with an associated second diopter power. The force placed on the capsule by tensioning and untensioning of the zonules causes the lens to move between its first and second configurations and diopter strengths, thereby providing lens accommodation to the patient.