Abstract: Arrhythmic foci and other driver sites can be mapped using a multi-dimensional catheter. For instance, using a clique of three or more electrodes on the multi-dimensional catheter, an electroanatomical mapping system can identify a maximum bipolar voltage and an average unipolar voltage. The ratio of the average unipolar voltage to the maximum bipolar voltage can be interpreted as an indication of whether a cardiac location is an arrhythmic focus. Alternatively, an evaluation region can be defined about location in the patient's heart. The evaluation includes a plurality of rods, each associated with a respective E-field loop having a respective maximum and minimum amplitude bipole axes, with the rods being defined by the maximum amplitude bipole axes. For a sufficient number of rods within the evaluation region, a focus score for the evaluation region can be computed to reflect rod orientation consistency within the evaluation region.

Abstract: A closure that remains coupled to a container after the upper portion of the closure has been rotatably removed from the container. The closure may include an attachment channel, which includes alternating segments of linear openings and frangible connections. The attachment channel may also include two hinge bridges that remain unbroken when one or more of the frangible connections are broken.

Abstract: A closure that remains coupled to a container after the upper portion of the closure has been rotatably removed from the container. The closure may include an attachment channel, which includes alternating segments of linear openings and frangible connections. The attachment channel may also include two hinge bridges that remain unbroken when one or more of the frangible connections are broken.

Abstract: Arrhythmic foci and other driver sites can be mapped using a multi-dimensional catheter. For instance, using a clique of three or more electrodes on the multi-dimensional catheter, an electroanatomical mapping system can identify a maximum bipolar voltage and an average unipolar voltage. The ratio of the average unipolar voltage to the maximum bipolar voltage can be interpreted as an indication of whether a cardiac location is an arrhythmic focus. Alternatively, an evaluation region can be defined about location in the patient's heart. The evaluation includes a plurality of rods, each associated with a respective E-field loop having a respective maximum and minimum amplitude bipole axes, with the rods being defined by the maximum amplitude bipole axes. For a sufficient number of rods within the evaluation region, a focus score for the evaluation region can be computed to reflect rod orientation consistency within the evaluation region.

Abstract: Described is one or more embodiments of closures that include a pressure-relieving feature in a third plug. In one embodiment, the pressure-relieving feature is a gap within the third plug. In another embodiment, the pressure-relieving feature includes one or more recesses within inner surface of the third plug, thereby providing fluid communication between an outer surface of the second plug and the ambient air outside the closure.

Abstract: A system, apparatus, and method include a pump to deliver vapor including airborne contaminants including organic compounds including a target analyte; a collector to transfer the airborne contaminants by autonomous liquid extraction into a mobile organic liquid phase; a micro-fluidic chamber including immobilized biorecognition elements that bind to analytes delivered from the mobile organic liquid phase; a mechanism to introduce the mobile organic liquid phase to a buffer containing a plurality of substrates causing a series of biochemical reactions that create a change corresponding to a concentration of the target analyte; and a detector to perform real-time analysis that correlates to a concentration of the organic compounds to determine a presence of the target analyte.

Abstract: A closure for a container is provided with a top portion and a skirt depending from an outer periphery of the top portion. A generally circular rim extends downwards from the lower surface of the top portion. A liner is attached to the closure between an outer surface of the rim and an inner surface of the skirt. The liner is configured to provide a fluid tight seal for containers having varied neck dimensions and/or profiles. One or more projections extend into a space formed between the lower surface of the top portion, an inner surface of the skirt, and an outer surface of the rim, with the liner enveloping and being supported in the closure by the one or more projections.

Abstract: A system, apparatus, and method include a pump to deliver vapor including airborne contaminants including organic compounds including a target analyte; a collector to transfer the airborne contaminants by autonomous liquid extraction into a mobile organic liquid phase; a micro-fluidic chamber including immobilized biorecognition elements that bind to analytes delivered from the mobile organic liquid phase; a mechanism to introduce the mobile organic liquid phase to a buffer containing a plurality of substrates causing a series of biochemical reactions that create a change corresponding to a concentration of the target analyte; and a detector to perform real-time analysis that correlates to a concentration of the organic compounds to determine a presence of the target analyte.

Abstract: A closure for a container is provided with a top portion and a skirt depending from an outer periphery of the top portion. A generally circular rim extends downwards from the lower surface of the top portion. A liner is attached to the closure between an outer surface of the rim and an inner surface of the skirt. The liner is configured to provide a fluid tight seal for containers having varied neck dimensions and/or profiles. One or more projections extend into a space formed between the lower surface of the top portion, an inner surface of the skirt, and an outer surface of the rim, with the liner enveloping and being supported in the closure by the one or more projections.

Abstract: A closure includes a cap having a top wall and a skirt perpendicular to the top wall and extending downwardly from the top wall to a lower edge. The skirt includes an inner surface having a sealing formation. A band is concentric with and attached to the lower edge of the skirt by a plurality of frangible members. The band remains coupled to the body of the closure even after being removed from a container.

Abstract: A closure includes a cap having a top wall and a skirt perpendicular to the top wall and extending downwardly from the top wall to a lower edge. The skirt includes an inner surface having a sealing formation. A band is concentric with and attached to the lower edge of the skirt by a plurality of frangible members. The band remains coupled to the body of the closure even after being removed from a container.

Abstract: A closure includes a cap having a top wall and a skirt perpendicular to the top wall and extending downwardly from the top wall to a lower edge. The skirt includes an inner surface having a sealing formation. A band is concentric with and attached to the lower edge of the skirt by a plurality of frangible members. A tab is formed at a hinge location from the band and extending from the lower edge of the skirt to one or more lines of weakness.

Abstract: Arrhythmic foci and other driver sites can be mapped using a multi-dimensional catheter. For instance, using a clique of three or more electrodes on the multi-dimensional catheter, an electroanatomical mapping system can identify a maximum bipolar voltage and an average unipolar voltage. The ratio of the average unipolar voltage to the maximum bipolar voltage can be interpreted as an indication of whether a cardiac location is an arrhythmic focus. Alternatively, an evaluation region can be defined about location in the patient's heart. The evaluation includes a plurality of rods, each associated with a respective E-field loop having a respective maximum and minimum amplitude bipole axes, with the rods being defined by the maximum amplitude bipole axes. For a sufficient number of rods within the evaluation region, a focus score for the evaluation region can be computed to reflect rod orientation consistency within the evaluation region.

Abstract: Described is one or more embodiments of closures that include a pressure-relieving feature in a third plug. In one embodiment, the pressure-relieving feature is a gap within the third plug. In another embodiment, the pressure-relieving feature includes one or more recesses within inner surface of the third plug, thereby providing fluid communication between an outer surface of the second plug and the ambient air outside the closure.

Abstract: Arrhythmic foci and other driver sites can be mapped using a multi-dimensional catheter. For instance, using a clique of three or more electrodes on the multi-dimensional catheter, an electroanatomical mapping system can identify a maximum bipolar voltage and an average unipolar voltage. The ratio of the average unipolar voltage to the maximum bipolar voltage can be interpreted as an indication of whether a cardiac location is an arrhythmic focus. Alternatively, an evaluation region can be defined about location in the patient's heart. The evaluation includes a plurality of rods, each associated with a respective E-field loop having a respective maximum and minimum amplitude bipole axes, with the rods being defined by the maximum amplitude bipole axes. For a sufficient number of rods within the evaluation region, a focus score for the evaluation region can be computed to reflect rod orientation consistency within the evaluation region.

Abstract: A lightweight neck finish includes a retaining structure that interacts with a tamper band to cause frangible connectors between the tamper band and closure to break upon initial removal of the closure from the neck finish. An upper retention portion of the retaining structure has a profile with a reduced footprint as compared to a conventional retaining structure. A lower support portion of the retaining structure has an outermost diameter similar in size to an outermost diameter of a conventional retaining structure. However, the lower support of the lightweight neck finish is formed with one or more circumferentially extending slots and/or one or more vertical slots. The reduced footprint of the retention portion and the slots of the support portion minimize the amount of material, weight, and time and cost required to make the lightweight neck finish, while providing for increased tamper evidence visibility as compared to conventional neck finishes.

Abstract: A closure that remains coupled to a container after the upper portion of the closure has been rotatably removed from the container. The closure may include an attachment channel, which includes alternating segments of linear openings and frangible connections. The attachment channel may also include two hinge bridges that remain unbroken when one or more of the frangible connections are broken.