Abstract: An electronic platform is disclosed that helps extend the lifespan of relationships, for example, between a salesperson and their client. The platform allows the user to have an account in which the user can store content which may be provided to a second user in an exclusive session through a generated unique URL. The platform is configured to selectively share only what one user wants to a particular recipient. A user interface connected through the unique URL is only accessible by the two users. The interface may provide each user with a section of the display from which to interact with the other user by using selectable features that are shared by both users on the interface. A duality of use is achieved through two-way communication through the page of the interface which helps build the relationship by each side providing feedback to the other side.

Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: The present disclosure relates to an interference screw having a body with a proximal end, distal end, and longitudinal axis extending between thereinbetween. The screw further includes threads for fixing the screw into bone. The screw further includes a through bore defined by the body. The through bore extends between the proximal and distal ends along the longitudinal axis, and has a surface. The screw further includes a controlling member formed by the through bore surface. To install the screw into bone, a surgeon turns the screw with a driver that engages with the controlling member. The driver only engages the controlling member when it is in a driving orientation with respect to the controlling member. Advantageously, with this “one-way” engagement the surgeon can control and confirm the orientation of the driver without seeing the driver and/or screw.

Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Abstract: The present disclosure provides systems and methods directed to a social-financial platform. In certain embodiments, sponsor-members, consumer-members, and beneficiary members are part of a social-financial platform in which purchases made by consumer-members at merchant sponsor-members result in automatic rebates being paid to and allocated between the consumer member and one or more beneficiary-members. Also disclosed is a monolithic financial structure for carrying out rebate allocation automatically and instantaneously, and for transferring funds between users.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Abstract: An airfoil for a gas turbine engine includes a first sidewall and a second sidewall coupled together at a leading edge and a trailing edge, such that a cavity is defined therebetween. A plurality of cooling circuits are defined within the cavity. Each cooling circuit channels cooling fluid through at least one cooling chamber to facilitate cooling the airfoil. More specifically, a cascade impingement circuit, a down pass circuit, a flag tip circuit, and a trailing edge circuit are provided. The cascade impingement circuit includes a central chamber and a plurality of impingement chambers.

Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Abstract: The present disclosure relates to an interference screw having a body with a proximal end, distal end, and longitudinal axis extending between thereinbetween. The screw further includes threads for fixing the screw into bone. The screw further includes a through bore defined by the body. The through bore extends between the proximal and distal ends along the longitudinal axis, and has a surface. The screw further includes a controlling member formed by the through bore surface. To install the screw into bone, a surgeon turns the screw with a driver that engages with the controlling member. The driver only engages the controlling member when it is in a driving orientation with respect to the controlling member. Advantageously, with this “one-way” engagement the surgeon can control and confirm the orientation of the driver without seeing the driver and/or screw.

Abstract: An airfoil for a gas turbine engine includes a first sidewall and a second sidewall coupled together at a leading edge and a trailing edge, such that a cavity is defined therebetween. A plurality of cooling circuits are defined within the cavity. Each cooling circuit channels cooling fluid through at least one cooling chamber to facilitate cooling the airfoil. More specifically, a cascade impingement circuit, a down pass circuit, a flag tip circuit, and a trailing edge circuit are provided. The cascade impingement circuit includes a central chamber and a plurality of impingement chambers.

Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

Abstract: A method and design for cooling the temperature of induction air fed into a motor vehicle engine, which includes an intercooler housed in an induction plenum. The intake side of the plenum feeds air compressed by a supercharger or turbocharger to the intercooler core. The intercooler core consists of a series of cooling cylinders, held side by side in an arched arrangement by a rigid cartridge. The use of the multiple cooling cylinders increases the surface area of the intercooler presented to the airstream, and thus the efficiency of the intercooler. The use of a rigid cartridge that contains the cooling cylinders, and fits inside a pair of matching machined end caps which simultaneously hold the cartridge and feed coolant to the intercooler cores, enables efficient assembly of the intercooler. The system design is readily adaptable for various engine conformations.

Abstract: A non-contact apparatus is provided for monitoring the height of contents of a moving container, such as a beverage can 24 on a conveyor 14. The apparatus comprises non-contact ultrasonic wave generation means comprising a first electromagnetic acoustic transducer 16 disposed to one side of a container 24 being monitored and adapted to produce an ultrasonic wave pulse in the container, and non-contact ultrasonic wave detector means comprising a second electromagnetic acoustic transducer 18 adapted to detect an ultrasonic signal and to generate a detection signal dependent upon the ultrasonic signal which is detected, the detector means being disposed at a different position to the side of a container 24 from the generation means. The apparatus further including signal processing means 20 adapted to process the detection signal generated by the ultrasonic wave detector means using the difference in transit times for two waves to provide an indication of the level of the contents in the container 24.

Abstract: The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked to the coding sequence. The present invention further provides a transgenic non-human animal whose genome incorporates a polynucleotide comprising a coding sequence which encodes the human ASP2 protein wherein the coding sequence is operably linked to a brain-specific calcium calmodulin kinase II promoter.

Abstract: An impact reduction vehicle bumper system for a vehicle has a pedestrian safety plate, which is connected to a steel bumper beam and occupies the region between a pair of frame rails that are disposed on the front of the vehicle. The bumper beam is connected to side brackets, which are bolted to the vehicle frame rails. Frame rail extensions are located in front of the frame rails and are welded to the side brackets.