Abstract: Systems and method in accordance with an embodiment of the present invention can includes an implant comprising a spacer and a frame having a central body and a helical shaped wing extending from the central body. The frame can be positioned near about adjacent spinous processes, and can be rotated and urged so that the adjacent spinous processes pass within a groove of the wing, thereby allowing the wing to be arranged on an opposite side of the adjacent spinous processes. The spacer can then be arranged over the frame so that the spacer contacts and distracts the spinous processes, thereby limiting relative movement of the adjacent spinous processes during extension.

Abstract: An artificial vertebral disk replacement implant is disclosed along with its method of operation and a method of implanting. The implant has first and second plates that each mate with a vertebral body. Each plate has one side for mating with a vertebral body. The first plate has a socket on one side, and the second plate has an elongated ball on one side. The ball of the first plate and the socket of the second plate form a ball-and-socket joint when the two plates are in contact with each other. The implant achieves a range of motion equivalent to a natural range of motion.

Abstract: The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.

Abstract: Systems and method in accordance with the embodiments of the present invention can include an implant for positioning within a cervical facet joint for distracting the cervical spine, thereby increasing the area of the canals and openings through which the spinal cord and nerves must pass, and decreasing pressure on the spinal cord and/or nerve roots. The implant can be inserted laterally or posteriorly.

Abstract: Systems and method in accordance with embodiments of the present invention can includes an implant having a spacer with an expandable portion. An insert can be positioned within a groove of the spacer to distract the expandable portion away from the main portion of the spacer. The expandable portion can optionally include a grip that can at least partially deform to conform to a contour of a spinous process to provide a frictional grip to prevent the implant from shifting position. Implants in accordance with the present invention can also include a binder that can be arranged around the adjacent spinous processes to limit flexion movement.

Abstract: Systems in accordance with embodiments of the present invention can include an implant comprising a spacer for defining a minimum space between adjacent spinous processes, a distraction guide for piercing and distracting an interspinous ligament during implantation, and a binder for limiting or preventing flexion motion of the targeted motion segment. The binder can be secured to a brace associated with the implant during implantation by a capture device. In one embodiment, the capture device includes a fixed piece extending from the brace and a slidable piece associated with the fixed piece. A fastener can be rotated to pinch the binder between the slidable piece and a wall of the brace, securing the binder. A physician need not know the length of the binder prior to implantation, reducing the time required to perform a procedure.

Abstract: A tool for securing a connector on a conductor using an explosive charge includes a first tool member, a second tool member, a drive member, a lock member and a limiting member. The second tool member is movably mounted on the first tool member. A breech chamber is defined in at least one of the first and second tool members. The breech chamber is adapted to receive the explosive charge. A breech opening is defined in at least one of the first and second tool members. The breech opening communicates with the breech chamber. The tool is adapted to forcibly move the drive member responsive to an explosion of the explosive charge in the breech chamber. The second tool member is movable between a closed position, wherein the breech opening is closed, and an open position, wherein the breech opening is open to allow loading and unloading of the explosive charge into and from the breech chamber, by moving the second tool member relative to the first tool member.

Abstract: The present invention is directed to a device that can be placed between two vertebrae. The implant is characterized by having a first plate and a second plate with a spacer therebetween. The spacer fits within cavities on each of the first and second plate.

Abstract: An implant is used to distract and maintain the distraction of spinous processes of adjacent vertebrae of the spine. The implant can be secured to a spine stabilization system.

Abstract: A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

Abstract: This invention relates to tools for preparing vertebral bodies in the spine for the implantation of an artificial vertebral disk replacement and related method. A first tool is disclosed that prepares the vertebral bodies for implantation by cutting offset channels in the vertebral bodies. The second tool holds two plates of the implant during the implantation process. This invention also relates to an artificial vertebral disk replacement, a method of operation, and a method of implanting.

Abstract: An intervertebral implant has a fusion body with at least one keel that anchors the implant into cancellous bone of at least one vertebral body. A method for implantation includes lateral implantation of the implant.

Abstract: An intervertebral implant has a fusion body with at least one keel that anchors the implant into cancellous bone of at least one vertebral body. A method for implantation includes lateral implantation of the implant.

Abstract: A system and method for replacing degenerated spinal disks in accordance with the present invention can substitute for interbody fusion techniques by replacing degenerated spinal disks with artificial spinal disks. In one embodiment, the system can comprise one or more artificial spinal disks, each comprising an upper and lower housing, a first spacer and a second spacer partially enclosed by a cavity formed by the housings, and a shaft with a spring positioned between the first spacer and the second spacer such that the spacers are urged apart.

Abstract: A tool for securing a connector on a conductor using an explosive charge includes a first tool member, a second tool member, a drive member, a lock member and a limiting member. The second tool member is movably mounted on the first tool member. A breech chamber is defined in at least one of the first and second tool members. The breech chamber is adapted to receive the explosive charge. A breech opening is defined in at least one of the first and second tool members. The breech opening communicates with the breech chamber. The tool is adapted to forcibly move the drive member responsive to an explosion of the explosive charge in the breech chamber. The second tool member is movable between a closed position, wherein the breech opening is closed, and an open position, wherein the breech opening is open to allow loading and unloading of the explosive charge into and from the breech chamber, by moving the second tool member relative to the first tool member.

Abstract: The present invention is directed to an interspinous process device with a deflectable spacer which can be placed between adjacent spinous processes to limit the movement of the vertebrae. The device limits the range of motion of the spinous processes. The spacer and a lead-in distraction guide or tissue expander can be radiolucent.

Abstract: An implant for positioning between the spinous processes of cervical vertebrae include first and second wings for lateral positioning and a spacer located between the adjacent spinous processes. The implant can be positioned using minimally invasive procedures without modifying the bone or severing ligaments. The implant is shaped in accordance with the anatomy of the spine.

Abstract: Systems and method in accordance with embodiment of the present invention can includes a distractible implant comprising a distracting insert and a body having a first part and a second part adapted to be positioned between adjacent spinous processes of cervical vertebrae. The distracting insert can be inserted into cavities of the body, thereby urging apart the first part and second part, and distracting the adjacent spinous processes.

Abstract: The present invention is directed to a device that can be placed between two vertebrae. The implant is characterized by having a first plate and a second plate with a crossbar therebetween. The crossbar fits within cavities on each of the first and second plates and allows for pivotal or rotational motion and also for twisting motion.

Abstract: The present invention is directed to a device with that can be placed between two vertebrae. The implant is characterized by having a first plate and a second plates with a crossbar therebetween. The crossbar fits within cavities on each of the first and second plate and allows for pivotal or rotational motion and also for twisting motion.