Patents by Inventor Steve Ruben
Steve Ruben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120076725Abstract: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.Type: ApplicationFiled: January 12, 2011Publication date: March 29, 2012Applicant: CELERA CORPORATIONInventors: Charles BIRSE, Marcia LEWIS, Steve RUBEN, Mehdi MESRI
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Patent number: 8110373Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.Type: GrantFiled: July 17, 2009Date of Patent: February 7, 2012Assignee: Celera CorporationInventors: Steve Ruben, Candy N. Lee, Bruno Domon
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Publication number: 20110271357Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.Type: ApplicationFiled: October 25, 2010Publication date: November 3, 2011Applicant: CELERA CORPORATIONInventors: Yeounjin KIM, Tao HE, Steve RUBEN
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Publication number: 20110250204Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.Type: ApplicationFiled: October 8, 2010Publication date: October 13, 2011Applicant: CELERA CORPORATIONInventors: Steve RUBEN, Paul A. MOORE, Tao HE, Candy N. LEE, Karen VAN ORDEN, Charles E. Birse, Mehdi Mesri, Elizabeth G. Joseloff
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Publication number: 20110212085Abstract: The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.Type: ApplicationFiled: August 19, 2010Publication date: September 1, 2011Applicant: CELERA CORPORATIONInventors: Elizabeth JOSELOFF, Aiqun LI, Tao HE, Steve RUBEN
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Patent number: 7998689Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.Type: GrantFiled: September 10, 2009Date of Patent: August 16, 2011Assignee: Celera CorporationInventors: Elizabeth Joseloff, Steve Ruben, Tao He, Yeounjin Kim
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Publication number: 20110093962Abstract: The present invention provides a method for diagnosing and detecting diseases associated with breast. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in breast diseases (BCAT) and antibodies binds to BCAT. The present invention provides that BCAT is used as targets for screening agents that modulates the BCAT activities. Further the present invention provides methods for treating diseases associated with breast.Type: ApplicationFiled: October 22, 2010Publication date: April 21, 2011Applicant: CELERA CORPORATIONInventors: Jenny HEIDBRINK, Steve RUBEN, Charles E. BIRSE, Tao HE
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Patent number: 7892760Abstract: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.Type: GrantFiled: November 19, 2008Date of Patent: February 22, 2011Assignee: Celera CorporationInventors: Charles Birse, Marcia Lewis, Steve Ruben, Mehdi Mesri
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Patent number: 7842467Abstract: The present invention provides a method for diagnosing and detecting diseases associated with breast. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in breast diseases (BCAT) and antibodies binds to BCAT. The present invention provides that BCAT is used as targets for screening agents that modulates the BCAT activities. Further the present invention provides methods for treating diseases associated with breast.Type: GrantFiled: May 29, 2008Date of Patent: November 30, 2010Assignee: Celera CorporationInventors: Jenny Heidbrink, Steve Ruben, Charles E. Birse, Tao He
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Patent number: 7842291Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.Type: GrantFiled: May 22, 2007Date of Patent: November 30, 2010Assignee: Celera CorporationInventors: Steve Ruben, Paul A. Moore, Tao He, Candy N. Lee, Karen Van Orden, Charles E. Birse, Mehdi Mesri, Elizabeth G. Joseloff
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Patent number: 7842466Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.Type: GrantFiled: February 19, 2008Date of Patent: November 30, 2010Assignee: Celera CorporationInventors: Yeounjin Kim, Tao He, Steve Ruben
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Publication number: 20100239581Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.Type: ApplicationFiled: September 10, 2009Publication date: September 23, 2010Applicant: CELERA CORPORATIONInventors: Elizabeth JOSELOFF, Steve RUBEN, Tao HE, Yeounjin KIM
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Patent number: 7776555Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.Type: GrantFiled: July 2, 2007Date of Patent: August 17, 2010Assignee: Celera CorporationInventors: Bruno Domon, Steve Ruben, Charles E. Birse, Yeoun Jin Kim, Tao He, Ian McCaffery
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Publication number: 20100061977Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.Type: ApplicationFiled: July 17, 2009Publication date: March 11, 2010Applicant: CELERA CORPORATIONInventors: Steve RUBEN, Karen VAN ORDEN, Candy N. LEE, Tao HE, Mehdi MESRI, Elizabeth G. JOSELOFF, Paul MOORE, Katherine MCKINNON, Bruno DOMON
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Publication number: 20100040637Abstract: Methods and compositions for detecting and treating diseases, especially cancer, and particularly breast, bladder, colon, gastrointestinal, kidney, liver, lung, melanoma, ovary, pancreatic, pharyngeal, prostate cancer and renal, associated with differential expression of prominin-1 (CD133) in disease cells compared to healthy cells. Also provided are antagonists or agonists of prominin-1, and methods for screening agents that modulate the prominin-1 level or activity in vivo or in vitro.Type: ApplicationFiled: November 22, 2006Publication date: February 18, 2010Inventors: Karen Van Orden, Maria Leai Smith, Albina Nesterova, Candy Lee, Steve Ruben
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Patent number: 7611703Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.Type: GrantFiled: March 13, 2007Date of Patent: November 3, 2009Assignee: Celera CorporationInventors: Elizabeth G. Joseloff, Yeoun Jin Kim, Tao He, Steve Ruben
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Patent number: 7608413Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.Type: GrantFiled: July 20, 2007Date of Patent: October 27, 2009Assignee: Celera CorporationInventors: Elizabeth Joseloff, Steve Ruben, Tao He, Yeoun Jim Kim
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Patent number: 7582441Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.Type: GrantFiled: December 7, 2006Date of Patent: September 1, 2009Assignee: Celera CorporationInventors: Steve Ruben, Candy N. Lee, Bruno Domon
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Publication number: 20090196873Abstract: Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.Type: ApplicationFiled: June 6, 2008Publication date: August 6, 2009Applicant: APPLERA CORPORATIONInventors: Bruno Domon, Charles E. Birse, Candy Lee, Steve Ruben
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Publication number: 20090123461Abstract: The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.Type: ApplicationFiled: October 21, 2008Publication date: May 14, 2009Applicant: Celera CorporationInventors: William Fitzhugh, Steve Ruben, Vaibhav Narayan, Charles E. Birse