Patents by Inventor Steve Ruben

Steve Ruben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lung disease targets and uses thereof
    Patent number: 7521195
    Abstract: The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: April 21, 2009
    Assignee: Celera Corporation
    Inventors: Elizabeth Joseloff, Aiqun Li, Tao He, Steve Ruben
  • Pancreatic cancer secreted targets and uses thereof
    Publication number: 20080219992
    Abstract: The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.
    Type: Application
    Filed: February 13, 2008
    Publication date: September 11, 2008
    Applicant: APPLERA CORPORATION
    Inventors: Kim Alving, Steve Ruben, Ian McCaffery, Bruno Domon
  • Methods and compositions for treating diseases targeting CDCP1
    Publication number: 20070031419
    Abstract: Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.
    Type: Application
    Filed: June 28, 2006
    Publication date: February 8, 2007
    Applicant: APPLERA CORPORATION
    Inventors: Bruno Domon, Charles Birse, Candy Lee, Steve Ruben
  • Human podocalyxin alternative-spliced forms and uses thereof
    Publication number: 20060294607
    Abstract: The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.
    Type: Application
    Filed: March 29, 2006
    Publication date: December 28, 2006
    Applicant: APPLERA CORPORATION
    Inventors: William Fitzhugh, Steve Ruben, Vaibhav Narayan, Charles Birse
  • Novel metalloproteinases
    Publication number: 20050118679
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Application
    Filed: November 2, 2004
    Publication date: June 2, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen
  • Metalloproteinases
    Patent number: 6878812
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: April 12, 2005
    Assignee: Human Genome Science, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen
  • Human DNA mismatch repair polynucleotides
    Patent number: 6482606
    Abstract: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: November 19, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Mark D. Adams, Robert D. Fleischmann, Claire M. Fraser, Rebecca A. Fuldner, Ewen F. Kirkness, William A. Haseltine, Craig A. Rosen, Steve Ruben, Ying-Fei Wei
  • Human DNA mismatch repair proteins
    Patent number: 6380369
    Abstract: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: April 30, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Mark D. Adams, Robert D. Fleischmann, Claire M. Fraser, Rebecca A. Fuldner, Ewen F. Kirkness, William A. Haseltine, Craig A. Rosen, Steve Ruben, Ying-Fei Wei
  • Novel Metalloproteinases
    Publication number: 20020042119
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Application
    Filed: September 13, 2001
    Publication date: April 11, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen
  • Metalloproteinases
    Patent number: 6312937
    Abstract: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: November 6, 2001
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen
  • Metalloproteinases
    Patent number: 6046031
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 4, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steve Ruben, Laurie Brewer, Reiner Gentz, Craig Rosen