Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: A computer system optionally displays a user interface object that reveals content based on whether the content is private or shared. A computer system optionally displays a user interface object that includes shared content based on whether participants have entitlement to the content. A computer system optionally displays a sharing indicator that indicates that the respective content is shared with one or more other participants.

Abstract: Some embodiments of the disclosure are directed to a novel system for pumping liquid such as blood without damaging cells. In some embodiments, the system includes one or more inflatable elements such as balloons which force liquid from an implanted pump. In some embodiments, one or more elements are configured to directionally inflate. In some embodiments, the directional inflation enables pumping in a bidirectional manner. In some embodiments, the system includes a plurality of elements that inflate sequentially to pump liquid in one direction or another. In some embodiments, the one or more elements are coupled to a tube or stent.

Abstract: The present disclosure relates to special purpose vending machines (SPVMs) methods of use thereof, and computer readable mediums (CRMs) for operating the same. In certain aspects, the method includes receiving personally identifying information (PII) from a user, receiving, from the user, an order to purchase at least one item, transmitting the PII to a third-party verification service (TPVS), receiving at least one user verification from the TPVS, sending a code to the user, where the code may include order data corresponding to the at least one item purchased by the user, receiving a scan of the code from the user using a special purpose vending machine (SPVM), where the SPVM houses the at least one item purchased by the user, and instructing the SPVM to dispense the at least one item purchased by the user.

Abstract: Systems and methods for sensing water device run time, transmitting this data via a network to a database which analyzes, records and reports the individual run times and the aggregate use over any given timeframe. Sensors used to measure device use time do not directly measure flow rate, and may sense device run time by sensing water flow, through electronic signals, vibration, etc. The sensors may be battery powered and transmit discrete data packets via radio frequency to powered node units. A system of node units communicates with a central internet gateway which uploads the data packets to a cloud-based database which organizes, analyzes, stores and reports the information. The system allocates the cost of water flowing through a common water meter to a plurality of individual units within a collection of geographically proximate units. The systems are useful in multi-unit buildings or complexes having stacked plumbing.

Abstract: A first device may receive data inputs from data sources corresponding to raw weather, non-weather, and/or environmental data. The first device may generate targeted alerts based on the data inputs and transmit the targeted alerts to a second device associated with a user.

Abstract: A large reflector inflatable telescope. The telescope has an inflatable hull with a conical lower portion and a hemispherical upper portion. The conical portion is transparent to electromagnetic waves so that radio or light waves can reach an inner reflector, which is interposed between the conical portion and the hemispherical portion. The presence of the inner reflector allows the conical portion and the hemispherical portion to be inflated at different pressures such that the reflector becomes spherical or parabolic. If desired, the reflector can be made adjustable with a membrane behind the reflector that provides electro-static force to shape the reflector.

Abstract: A heat shrink tunnel with width adjustment includes a pair of opposing side wall assemblies, each including an outer wall and an inner perforated wall defining a plenum therebetween. The opposing side walls define a product path with the side wall assemblies being movable toward and away from each other. A heater/blower assembly disposed in each of the opposing side walls and has an outlet directed into the product path. A shroud extends over the side wall assemblies and an open top space between the side all assemblies. The side wall assemblies extend upwardly toward an inside of the shroud so as to define a small gap between tops of the side wall assemblies and the inside of the shroud. The shroud has a bottom wall. A conveyor is configured to convey items through the heat shrink tunnel. A tunnel includes a side wall assembly width adjusting assembly to move the side walls toward and away from one another by actuation of a single actuator.

Abstract: A large reflector inflatable telescope. The telescope has an inflatable hull with a conical lower portion and a hemispherical upper portion. The conical portion is transparent to electromagnetic waves so that radio or light waves can reach an inner reflector, which is interposed between the conical portion and the hemispherical portion. The presence of the inner reflector allows the conical portion and the hemispherical portion to be inflated at different pressures such that the reflector becomes spherical or parabolic. If desired, the reflector can be made adjustable with a membrane behind the reflector that provides electro-static force to shape the reflector.

Abstract: Systems and methods for sensing water device run time, transmitting this data via a network to a database which analyzes, records and reports the individual run times and the aggregate use over any given timeframe. Sensors used to measure device use time do not directly measure flow rate, and may sense device run time by sensing water flow, through electronic signals, vibration, etc. The sensors may be battery powered and transmit discrete data packets via radio frequency to powered node units. A system of node units communicates with a central internet gateway which uploads the data packets to a cloud-based database which organizes, analyzes, stores and reports the information. The system allocates the cost of water flowing through a common water meter to a plurality of individual units within a collection of geographically proximate units. The systems are useful in multi-unit buildings or complexes having stacked plumbing.

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

Abstract: A ventricular assist device for use in a human recipient includes a housing within which a series pair of turbine pump segments and at least one set of deswirlers are operative. The series pair of turbine pump segments provides a redundancy in turn enhances the safety factor provided by the ventricular assist device. A controller is powered by a rechargeable battery and is operative to apply appropriate drive signals to the motor drives of the turbine pump segments. The battery may be implanted along with the controller to avoid the need for any external connections to the ventricular assist device. An inductively coupled battery charger for use outside the recipient's body is positioned proximate the battery charger to provide inductively coupled charging for use in driving the ventricular assist device.

Abstract: Systems and methods for sensing water device run time, transmitting this data via a network to a database which analyzes, records and reports the individual run times and the aggregate use over any given timeframe. Sensors used to measure device use time do not directly measure flow rate, and may sense device run time by sensing water flow, through electronic signals, vibration, etc. The sensors may be battery powered and transmit discrete data packets via radio frequency to powered node units. A system of node units communicates with a central internet gateway which uploads the data packets to a cloud-based database which organizes, analyzes, stores and reports the information. The system allocates the cost of water flowing through a common water meter to a plurality of individual units within a collection of geographically proximate units. The systems are useful in multi-unit buildings or complexes having stacked plumbing.

Abstract: A ventricular assist device for use in a human recipient includes a housing within which a series pair of turbine pump segments, each having a deswirler, are operative. The series pair of turbine pump segments provides a redundancy which in turn enhances the safety factor provided by the ventricular assist device.

Abstract: An anti-rotation and assembly aid clamp for use in coupling a turbocharger and a catalytic converter. The clamp can include a ring body configured to circumferentially clamp the outlet flange to the inlet flange, a torque application device configured to apply a force about the ring body, and an anti-rotation assembly device configured to be engageable with a first coupling post extending from the turbocharger and a second coupling post extending from the convert to exert a clamping force urging the outlet flange toward the inlet flange.

Abstract: An emissions monitoring and management system includes a containment assembly that defines an enclosed volume, wherein the enclosed volume of the containment assembly is configured to receive an industrial component, a fluid conduit coupled to the containment assembly and in fluid communication with the enclosed volume, an emissions conditioner coupled to the fluid conduit, wherein the emissions conditioner is configured to reduce a concentration of a predetermined gas of interest in the fluid conduit, a first emissions detector coupled to the containment assembly and in fluid communication with the enclosed volume, wherein the first emissions detector is configured to determine a concentration of the predetermined gas of interest in the enclosed volume, and a transmitter in signal communication with the first emissions detector, wherein the transmitter is configured to transmit signals corresponding to a first predetermined concentration of the predetermined gas of interest in the enclosed volume.

Abstract: An artificial heart for use in a human recipient includes a housing within which a quartet of turbine pump segments are operative. The quartet of turbine pump segments is configured to provide a pair of redundant input and output turbine pump segment pairs each input and output pair being coupled by a curved passage providing a redundancy which, in turn, enhances the safety factor provided by the artificial heart. Each turbine pump segment includes an impeller forwarded for rotation and having a plurality of impeller blades together with a static deswirler positioned within the impeller output flow to reduce the swirling turbulence of the blood flow induced by the rotating impeller.

Abstract: Systems and methods for sensing water device run time, transmitting this data via a network to a database which analyzes, records and reports the individual run times and the aggregate use over any given timeframe. Sensors used to measure device use time do not directly measure flow rate, and may sense device run time by sensing water flow, through electronic signals, vibration, etc. The sensors may be battery powered and transmit discrete data packets via radio frequency to powered node units. A system of node units communicates with a central internet gateway which uploads the data packets to a cloud-based database which organizes, analyzes, stores and reports the information. The system allocates the cost of water flowing through a common water meter to a plurality of individual units within a collection of geographically proximate units. The systems are useful in multi-unit buildings or complexes having stacked plumbing.

Abstract: A balloon reflector antenna for a satellite, including a spherical balloon with a surface transparent to electromagnetic waves and a reflective surface opposite the transparent surface. The balloon reflector antenna may further include a feed system extending from the center of the balloon that receives electromagnetic waves reflected off the reflective surface and/or outputs electromagnetic waves that are reflected off the reflective surface.

Abstract: An artificial heart for use in a human recipient includes a housing within which a trio of turbine pump segments are operative. Two of the turbine pumps form a series connected pair for redundancy. The redundancy enhances the safety factor provided by the artificial heart. A controller is powered by a rechargeable battery and is operative to apply appropriate drive signals to the motor drives of the turbine pump segments. The battery may be implanted along with the controller to avoid the need for any external connections to the artificial heart. An inductively coupled battery charger for use outside the recipient's body is positioned proximate the battery charger to provide inductively coupled charging for use in driving the artificial heart.