Patents by Inventor Steven A. Rosenberg

Steven A. Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITE POLYAMIDE MEMBRANE HAVING HIGH ACID CONTENT AND LOW AZO CONTENT
    Publication number: 20160317980
    Abstract: A thin film composite polyamide membrane comprising a porous support and a thin film polyamide layer characterized by possessing: i) an azo (—N?N—) content of from 0.30% to 0.80%, as measured by pyrolysis gas chromatography; and ii) a dissociated carboxylate content of at least 0.18 mol/kg as measured by RBS at pH 9.5.
    Type: Application
    Filed: December 15, 2014
    Publication date: November 3, 2016
    Inventors: Ian A. Tomlinson, Robert C. Cieslinski, Bruce B. Gerhart, David D. Hawn, Mou Paul, XiaoHua Qiu, Mark A. Rickard, Steven Rosenberg, Abhishek Roy, Chengli Zu
  • COMPOSITE POLYAMIDE MEMBRANE HAVING AZO CONTENT AND HIGH ACID CONTENT
    Publication number: 20160310909
    Abstract: A thin film composite polyamide membrane comprising a porous support and a thin film polyamide layer characterized by possessing: i) an azo (—N?N—) content of from 0.40% to 1.00%, as measured by pyrolysis gas chromatography; and ii) a dissociated carboxylate content of at least 0.40 mol/kg as measured by RBS at pH 9.5.
    Type: Application
    Filed: December 15, 2014
    Publication date: October 27, 2016
    Inventors: Mou PAUL, Robert C. CIESLINSKI, Bruce B. GERHART, David D. HAWN, XiaoHua QIU, Mark A. RICKARD, Steven ROSENBERG, Abhishek ROY, Ian A. TOMLINSON, Chengli ZU
  • COMPOSITE POLYAMIDE MEMBRANE HAVING PREFERRED AZO CONTENT
    Publication number: 20160303520
    Abstract: A thin film composite polyamide membrane comprising a porous support and a thin film polyamide layer characterized by possessing an azo (—N?N—) content of from 0.75% to 0.95%, as measured by pyrolysis gas chromatography.
    Type: Application
    Filed: December 15, 2014
    Publication date: October 20, 2016
    Inventors: Abhishek Roy, Robert C. Cieslinski, Bruce B. Gerhart, David D. Hawn, Mou Paul, XiaoHua Qiu, Mark A. Rickard, Steven Rosenberg, Ian A. Tomlinson, Chengli Zu
  • ANTI-SSX-2 T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
    Publication number: 20160279196
    Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
    Type: Application
    Filed: April 19, 2016
    Publication date: September 29, 2016
    Inventors: Richard A. Morgan, Nachimuthu Chinnasamy, Steven A. Rosenberg
  • MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
    Patent number: 9447144
    Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: September 20, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Rong-Fu Wang, Steven A. Rosenberg, Gang Zeng
  • Composite polyamide membrane derived from monomer including amine-reactive and phosphorous-containing functional groups
    Patent number: 9399196
    Abstract: A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a monomer comprising at least one phosphorous-containing functional group or salt thereof and an at least one amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: July 26, 2016
    Assignee: Dow Global Technologies LLC
    Inventors: Chunming Zhang, Aman A. Desai, Steven D. Jons, Mou Paul, Steven Rosenberg, Abhishek Roy, XiaoHua S. Qiu
  • ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III CHIMERIC ANTIGEN RECEPTORS AND USE OF SAME FOR THE TREATMENT OF CANCER
    Publication number: 20160200819
    Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
    Type: Application
    Filed: January 13, 2016
    Publication date: July 14, 2016
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Richard A. Morgan, Steven A. Rosenberg
  • Anti-mesothelin chimeric antigen receptors
    Patent number: 9359447
    Abstract: The invention provides a chimeric antigen receptor (CAR) (a) an antigen binding domain of HN1 or SS, a transmembrane domain, and an intracellular T cell signaling domain, or (b) an antigen binding domain of SS1, a transmembrane domain, an intracellular T cell signaling domain, and a granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor 2 leader. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: June 7, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Steven A. Feldman, Steven A. Rosenberg, Ira H. Pastan
  • ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS
    Publication number: 20160152681
    Abstract: Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
    Type: Application
    Filed: July 14, 2014
    Publication date: June 2, 2016
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Christian S. Hinrichs, Steven A. Rosenberg
  • METHODS OF PREPARING ANTI-HUMAN PAPILLOMAVIRUS ANTIGEN T CELLS
    Publication number: 20160144018
    Abstract: Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
    Type: Application
    Filed: July 14, 2014
    Publication date: May 26, 2016
    Applicant: The United States of America, as represented by The Secretary, Department of Health and Human Serv
    Inventors: Christian S. Hinrichs, Steven A. Rosenberg
  • Anti-SSX-2 T cell receptors and related materials and methods of use
    Patent number: 9345748
    Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: May 24, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Richard A. Morgan, Nachimuthu Chinnasamy, Dhanalakshmi Chinnasamy, Steven A. Rosenberg
  • Composite polyamide membrane derived from carboxylic acid containing acyl halide monomer
    Patent number: 9289729
    Abstract: A method for making a composite polyamide membrane comprising the step of applying polyfunctional amine and acid halide monomers to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer. The method further includes the step of conducting the interfacial polymerization in the presence of: a carboxylic acid monomer comprising an aliphatic or aromatic moiety substituted with single carboxylic acid functional group and at least one acyl halide functional group, and a tri-hydrocarbyl compound.
    Type: Grant
    Filed: March 16, 2013
    Date of Patent: March 22, 2016
    Inventors: Abhishek Roy, Steven D. Jons, Joseph D. Koob, Martin H. Peery, XiaoHua Sam Qiu, Steven Rosenberg, Ian A. Tomlinson
  • Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer
    Patent number: 9266960
    Abstract: The disclosure provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: February 23, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Richard A. Morgan, Steven A. Rosenberg
  • METHODS OF PRODUCING ENRICHED POPULATIONS OF TUMOR-REACTIVE T CELLS FROM TUMOR
    Publication number: 20160010058
    Abstract: Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample; (b) specifically selecting CD8+ T cells that express any one or more of TIM-3, LAG-3, 4-1BB, and PD-1 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
    Type: Application
    Filed: April 30, 2013
    Publication date: January 14, 2016
    Applicant: The United States of America, as represented by the Secretary, Department of health and human Serv
    Inventors: Alena Gros, Steven A. Rosenberg
  • METHODS OF PRODUCING ENRICHED POPULATIONS OF TUMOR REACTIVE T CELLS FROM PERIPHERAL BLOOD
    Publication number: 20160008400
    Abstract: Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood; (b) specifically selecting CD8+T cells that also express PD-1 and/or TIM-3 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
    Type: Application
    Filed: April 30, 2013
    Publication date: January 14, 2016
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alena Gros, Steven A. Rosenberg
  • METHODS FOR PRODUCING AUTOLOGOUS T CELLS USEFUL TO TREAT B CELL MALIGNANCIES AND OTHER CANCERS AND COMPOSITIONS THEREOF
    Publication number: 20150344844
    Abstract: Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided.
    Type: Application
    Filed: February 4, 2015
    Publication date: December 3, 2015
    Inventors: Marc Better, Steven A. Feldman, Steven A. Rosenberg
  • COMPOSITE POLYAMIDE MEMBRANE INCLUDING TRI-HYDROCARBYL PHOSPHATE
    Publication number: 20150314243
    Abstract: A method for making a composite polyamide membrane comprising a porous support and a thin film polyamide layer, wherein the method includes:i) applying a polar solution including a polyfunctional amine monomer and a non-polar solution including a polyfunctional acylhalide monomer to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, and wherein at least one or both of the solutions further includes a tri-hydrocarbyl phosphate compound and ii) exposing the thin film polyamide layer to nitrous acid.
    Type: Application
    Filed: January 3, 2014
    Publication date: November 5, 2015
    Inventors: Abhishek ROY, Yasushi MAEDA, Mou PAUL, Steven ROSENBERG, Ian A. TOMLINSON
  • Method for Determining Coronary Artery Disease Risk
    Publication number: 20150315652
    Abstract: Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 5, 2015
    Inventors: Steven Rosenberg, Michael R. Elashoff, Philip Beineke, James A. Wingrove, Whittemore G. Tingley, Susan E. Daniels
  • COMPOSITE POLYAMIDE MEMBRANE MADE VIA INTERFACIAL POLYMERIZATION USING A BLEND OF NON-POLAR SOLVENTS
    Publication number: 20150306548
    Abstract: A method for making a composite polyamide membrane comprising a porous support and a thin film polyamide layer, wherein the method includes: i) applying a polar solution comprising a polyfunctional amine monomer, and a non-polar solution comprising a polyfunctional acyl halide monomer to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the non-polar solution further comprises at least 50 vol % of a C5 to C20 aliphatic hydrocarbon and from 2 to 25 vol % of benzene or benzene substituted with one or more C1 to C6 alkyl groups; and ii) applying an aqueous solution of nitrous acid to the thin film polyamide layer.
    Type: Application
    Filed: January 3, 2014
    Publication date: October 29, 2015
    Inventors: Abhishek Roy, Yasushi Maeda, Mou Paul, Steven Rosenberg, Ian A. Tomlinson
  • COMPOSITE POLYAMIDE MEMBRANE MADE USING SUBSTITUTED BENZAMIDE MONOMER
    Publication number: 20150298066
    Abstract: A method for making a composite polyamide membrane comprising a porous support and a thin film polyamide layer, wherein the method includes the steps of applying a polar solution comprising a polyfunctional amine monomer and a non-polar solution comprising a polyfunctional acyl halide monomer to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer. The method is characterized by including a substituted benzamide monomer within the non-polar solution.
    Type: Application
    Filed: January 3, 2014
    Publication date: October 22, 2015
    Inventors: Abhishek Roy, Tina L. Arrowood, Aman A. Desai, Steven D. Jons, Mou Paul, XiaoHua Qiu, Steven Rosenberg, Ian A. Tomlinson