Patents by Inventor Steven A. Rosenberg

Steven A. Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T CELL RECEPTORS RECOGNIZING HLA-A1- OR HLA-CW7-RESTRICTED MAGE
    Publication number: 20140378389
    Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
    Type: Application
    Filed: September 11, 2012
    Publication date: December 25, 2014
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Paul F. Robbins, Steven A. Rosenberg, Shiqui Zhu, Steven A. Feldman, Richard A. Morgan
  • COMPOSITE POLYAMIDE MEMBRANE
    Publication number: 20140370191
    Abstract: A method for making a composite polyamide membrane including the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a subject monomer comprising at least one carboxylic acid group linked to an aromatic moiety and wherein the aromatic moiety is further substituted with at least one of an acyl halide or anhydride functional group and ii) applying the subject monomer to the thin film polyamide layer. The invention includes many additional embodiments.
    Type: Application
    Filed: January 3, 2013
    Publication date: December 18, 2014
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Steven Rosenberg, Steven D. Jons, Joseph D. Koob, Mou Paul, XiaoHua Qiu, Abhishek Roy, Chunming Zhang, Aman A. Desai
  • Method for determining coronary artery disease risk
    Patent number: 8914240
    Abstract: Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: December 16, 2014
    Assignee: Cardiodx, Inc.
    Inventors: Steven Rosenberg, Michael R. Elashoff, Philip Beineke, James A. Wingrove, Whittemore G. Tingley, Susan E. Daniels
  • NOVEL MHC CLASS II RESTRICTED T CELL EPITOPES FROM THE CANCER ANTIGEN, NY ESO-1
    Publication number: 20140335053
    Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 13, 2014
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Rong-Fu Wang, Steven A. Rosenberg, Gang Zeng
  • IN-SITU METHOD FOR PREPARING HYDROLYZED ACYL HALIDE COMPOUND
    Publication number: 20140264161
    Abstract: An in-situ method for preparing a hydrolyzed, acyl halide-containing compound by combining a reactant including a plurality of acyl halide functional groups containing reactant, a tri-hydrocarbyl phosphate compound and water within a hydrocarbon or halogenated hydrocarbon solvent.
    Type: Application
    Filed: March 16, 2013
    Publication date: September 18, 2014
    Applicant: Dow Global Technologies LLC
    Inventors: Abhishek Roy, Steven D. Jons, Joseph D. Koob, Martin H. Peery, XiaoHua Sam Qiu, Steven Rosenberg, Ian A. Tomlinson
  • METHOD FOR SOLUBILIZING CARBOXYLIC ACID-CONTAINING COMPOUND IN HYDROCARBON SOLVENT
    Publication number: 20140264162
    Abstract: A method for increasing the solubility of a hydrocarbon compound comprising an aliphatic or arene moiety substituted with at least one acyl halide and at least one carboxylic acid functional group within a hydrocarbon solvent, wherein the method includes the step of preparing a solution comprising: at least 80 v/v % of the hydrocarbon solvent, the hydrocarbon compound, and a tri-hydrocarbyl phosphate compound, wherein the concentration of the hydrocarbon compound is greater than its solubility limit within the solvent but less than its solubility limit in the solution and the hydrocarbon.
    Type: Application
    Filed: March 16, 2013
    Publication date: September 18, 2014
    Applicant: Dow Global Technologies LLC
    Inventors: XiaoHua Sam Qiu, Steven D. Jons, Joseph D. Koob, Martin H. Peery, Steven Rosenberg, Abhishek Roy, Ian A. Tomlinson
  • COMPOSITE POLYAMIDE MEMBRANE DERIVED FROM CARBOXYLIC ACID CONTAINING ACYL HALIDE MONOMER
    Publication number: 20140272134
    Abstract: A method for making a composite polyamide membrane comprising the step of applying polyfunctional amine and acid halide monomers to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer. The method further includes the step of conducting the interfacial polymerization in the presence of: a carboxylic acid monomer comprising an aliphatic or aromatic moiety substituted with single carboxylic acid functional group and at least one acyl halide functional group, and a tri-hydrocarbyl compound.
    Type: Application
    Filed: March 16, 2013
    Publication date: September 18, 2014
    Applicant: Dow Global Technologies LLC
    Inventors: Abhishek Roy, Steven D. Jons, Joseph D. Koob, Martin H. Peery, XiaoHua Sam Qiu, Steven Rosenberg, Ian A. Tomlinson
  • Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
    Patent number: 8822196
    Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: September 2, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Steven A. Rosenberg, Dhanalakshmi Chinnasamy
  • GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
    Publication number: 20140219978
    Abstract: The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
    Type: Application
    Filed: December 13, 2013
    Publication date: August 7, 2014
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Nicholas P. Restifo, Lydie Cassard, Zhiya Yu, Steven A. Rosenberg
  • METHOD FOR PREPARING HIGH PURITY MONO-HYDROLYZED ACYL HALIDE COMPOUND
    Publication number: 20140206900
    Abstract: A method for preparing a high purity (e.g. greater than 70 wt. %) mono-hydrolyzed acyl halide compound as a precipitate from solution comprising the steps of preparing a solution comprising: i) at least 80 v/v % of a hydrocarbon solvent, ii) water at a molar concentration greater than its solubility limit within the solvent but less that its solubility limit in solution, iii) a tri-hydrocarbyl phosphate compound, and iv) a polyfunctional acyl halide compound at molar ratio to both water and the tri-hydrocarbyl phosphate compound of at least 1:1.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 24, 2014
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: XiaoHua S. Qiu, Steven D. Jons, Joseph D. Koob, Martin H. Peery, Steven Rosenberg, Abhishek Roy, Ian A. Tomlinson
  • T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
    Publication number: 20140206620
    Abstract: The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Steven A. Rosenberg, Richard A. Morgan, Timothy L. Frankel
  • T cell receptors and related materials and methods of use
    Patent number: 8785601
    Abstract: The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: July 22, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Steven A. Rosenberg, Richard A. Morgan, Timothy L. Frankel, Peter Peng
  • COMPOSITE POLYAMIDE MEMBRANE INCLUDING TRI-HYDROCARBYL PHOSPHATE
    Publication number: 20140199483
    Abstract: A method for making a composite polyamide membrane comprising a porous support and a thin film polyamide layer, wherein the method includes: i) applying a polar solution comprising a polyfunctional amine monomer and a non-polar solution comprising a polyfunctional acyl halide monomer to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, and wherein the non-polar solution further comprises a tri-hydrocarbyl phosphate compound represented by Formula (I): wherein R1, R2 and R3 are independently selected from hydrogen and hydrocarbyl groups comprising from 1 to 10 carbon atoms, with the proviso that no more than one of R1, R2 and R3 are hydrogen; and ii) applying an aqueous solution of nitrous acid to the thin film polyamide layer.
    Type: Application
    Filed: January 15, 2014
    Publication date: July 17, 2014
    Inventors: Abhishek Roy, Yasushi Maeda, Mou Paul, Steven Rosenberg, Ian A. Tomlinson
  • COMPOSITE POLYAMIDE MEMBRANE DERIVED FROM MONOMER INCLUDING AMINE-REACTIVE AND PHOSPHOROUS-CONTAINING FUNCTIONAL GROUPS
    Publication number: 20140170314
    Abstract: A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a monomer comprising at least one phosphorous-containing functional group or salt thereof and an at least one amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer.
    Type: Application
    Filed: July 17, 2012
    Publication date: June 19, 2014
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Chunming Zhang, Aman A. Desai, Steven D. Jons, Mou Paul, Steven Rosenberg, Abhishek Roy, XiaoHua S. Qiu
  • MHC class II restricted T cell epitopes from the cancer anitgen, NY ESO-1
    Patent number: 8754046
    Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: June 17, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Rong-Fu Wang, Steven A. Rosenberg, Gang Zeng
  • Polyurethane adhesive for windshield applications
    Patent number: 8747602
    Abstract: A polyurethane adhesive which is useful in bonding porous and non-porous surfaces is provided. The adhesive is especially useful in bonding windshield glass into automotive frames under a variety of environmental conditions, particularly in after market windshield replacement applications. The polyurethane includes at least one urethane prepolymer which is based on at least one thermoplastic polyol. In one embodiment, the urethane prepolymer may be formed from one or more polyisocyanates, one or more polyetherpolyols and one or more thermoplastic polyesterpolyols, wherein the prepolymer has a free isocyanate content of from about 0.6 to about 3.5% by weight, based on the weight of the polyurethane. In another embodiment, a one-part adhesive composition is provided which includes an isocyanate-functional and thermoplastic polyurethane prepolymer having a free isocyanate content of from about 0.6 to about 3.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: June 10, 2014
    Assignee: Sika Technology AG
    Inventors: Steven Rosenberg, Hong Yao, Thomas Bove, Adrian Van Maurik, Hans Peter Tschan, Norman Blank
  • Determining Coronary Artery Disease Risk
    Publication number: 20140156198
    Abstract: Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
    Type: Application
    Filed: January 16, 2014
    Publication date: June 5, 2014
    Applicant: CARDIODX, INC.
    Inventors: Steven Rosenberg, Michael R. Elashoff, Philip Beineke, James A. Wingrove, Whittemore G. Tingley, Susan E. Daniels
  • ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III CHIMERIC ANTIGEN RECEPTORS AND USE OF SAME FOR THE TREATMENT OF CANCER
    Publication number: 20140037628
    Abstract: The disclosure provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
    Type: Application
    Filed: March 21, 2012
    Publication date: February 6, 2014
    Applicant: The United States of America, as rep., by the Secretary, Dept., of Health and Human Services.
    Inventors: Richard A. Morgan, Steven A. Rosenberg
  • GP100-specific T cell receptors and related materials and methods of use
    Patent number: 8613932
    Abstract: The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: December 24, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Nicholas P. Restifo, Lydie Cassard, Zhiya Yu, Steven A. Rosenberg
  • COMPOSITE POLYAMIDE MEMBRANE
    Publication number: 20130287944
    Abstract: A method for making a composite polyamide membrane including the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a subject monomer comprising an aromatic moiety substituted with a single carboxylic acid functional group or salt thereof and a single amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer. Many additional embodiments are described including applications for such membranes.
    Type: Application
    Filed: January 20, 2012
    Publication date: October 31, 2013
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Mou Paul, Steven D. Jons, Joseph D. Koob, XiaoHua Sam Qiu, Steven Rosenberg, Abhishek Roy