Abstract: A composition configured for oral use is provided, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: Meltable compositions configured for oral use, the compositions including at least one cannabinoid or cannabimimetic, are provided. The compositions include one or more fillers, typically a sugar alcohol, and a lipid. A method of forming such compositions is also provided.

Abstract: Devices, systems and methods that track various aspects of a person's sleep and environment to optimize one or more aspects of the user's environment and sleep conditions, quality and duration, together or alone, and help make the one or more users maintain and prolong his or her deep sleep status and improve the their sleep duration and quality.

Abstract: An uninterruptible power supply (UPS) is operated to selectively provide energy to a critical load from a grid and an energy storage device and to transfer energy between the energy storage device and the grid. A controller causes the UPS to selectively support bidirectional and unidirectional transfers of energy between the grid and the energy storage device based on a state of charge (SOC) of the energy storage device.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.

Abstract: A performance monitor determines a performance characteristic of a plurality of dispensers receiving fluid from a reservoir. Each of the plurality of dispensers has an actuator that, when actuated, causes the each of the dispensers to generate a droplet of the fluid. A driver generates a drive command to the actuator to adjust a physical attribute of the droplet based on the performance characteristic to satisfy a performance criteria.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Methods, systems, and devices for techniques to group media blocks are described. In some cases, a computing system may generate a memory map for a preconfigured size or chunk of data. For example, the computing system may divide files of media blocks into a set of fixed sized chunks of consecutive media blocks. Upon an application requesting a memory map for a set of media blocks, a storage layer of the computing system may generate a sub-map of the memory map for each chunk of data containing a media block of the set of requested media blocks. In some cases, the computing system may assign the chunks of data a continuous range of addresses in the virtual address space of the application. Upon generating the memory map, the storage layer may return an indication of the virtual address ranges of the requested media blocks to the application.

Abstract: Systems and methods for producing methanol are provided. A reformer feed gas including methane and carbon dioxide is provided to a methane reformer, which produces a synthesis gas. The synthesis gas includes a first portion of hydrogen, a second portion of carbon monoxide, and a third portion of carbon dioxide. The methane is present in the reformer feed gas in an amount of between 20 volume percent (vol %) and 90 vol % and the carbon dioxide is present in the reformer feed gas in an amount of between 10 vol % and 80 vol %. The synthesis gas is subjected to a methanol synthesis reactor. The methanol synthesis reactor is utilized to produce a methanol product and a purge gas stream from the synthesis gas.

Abstract: The present invention provides a method for detecting an analyte in a sample and a device for carrying out the method. The method comprises the following steps. (i) Providing a mixture comprising a sample, a reporter reagent, and a pre-activator reagent to a device, the device comprising a substrate having an optical component and a binding component, where the optical component and the binding component are attached to a surface of the substrate, the reporter reagent being capable of generating reactive oxygen species from the pre-activator reagent upon absorption of electromagnetic radiation, and the optical component being capable of changing from a first optical state to a second optical state on reaction with the reactive oxygen species. (ii) Allowing a portion of the reporter reagent to bind to the surface of the substrate in proportion to the concentration of the analyte, by means of the binding component.

Abstract: An electrical submersible pump assembly comprising a first section and a second section with an outer housing and a drive shaft. A coupling assembly comprising a coupling, a thrust pin, and a retainer ring mechanically couples the first drive shaft to the second drive shaft. The coupling is generally cylindrical in shape with splines formed along the inner surface configured to transfer torque from the first shaft to the second shaft. The thrust pin is installed in a pin bore in the lower shaft and extends into a retainer bore in the upper shaft. The retainer ring is installed between a groove in the retainer bore and a retainer groove on the outside of the thrust pin. The thrust pin is configured to transfer tensile stress from the retainer bore in first drive shaft to the pin bore in the second drive shaft.

Abstract: Methods, systems, and devices for techniques to balance log structured merge trees are described. A computing system may rebalance a tree structure having an ordered set of leaf nodes by splitting or joining leaf nodes of the tree structure. To split a leaf node, the computing system may select a key to evenly partition key and value data stored in the leaf. The computing system may place each key block of the leaf node having keys less than or equal to the selected key in a first new leaf node, and may place each key block of the leaf node having keys greater than the selected key in a second new leaf node. To join leaf nodes of the tree structure, the computing system may place each key block and each value block of the leaf node and the adjacent leaf node in a new leaf node.

Abstract: Pharmaceutical compositions containing anti-beta amyloid (A?) antibodies or A?-binding fragments thereof are provided. These pharmaceutical compositions find use in the treatment of abnormal accumulation or deposition of A? in the central nervous system, mild cognitive impairment, and A?-associated disorders such as Alzheimer's disease.

Abstract: A method for the fractionation of reclaimed polymer in at least one solvent in a process for purifying reclaimed polymers plastic recycling to increase their use in secondary applications. The reclaimed polymer is dissolved in a solvent within a reactor vessel having a stack of perforated discs which are oscillated. The linear motion of the stack speeds up dissolution time to minutes rather than hours and the required polymer to solvent ratio can be increased to 0.3 to 10% wt addition. Temperature and time effects are used to fractionate polymers of differing molecular weights to provide purified and graded plastics for secondary use at a commercially viable scale.

Abstract: A method and apparatus for transporting heavy machinery, equipment or other heavy loads from one location to another, whereby the apparatus may be constructed as a walking machine including a plurality of lifting assemblies operative to lift the load above the supporting surface and then move the load relative to the supporting surface by transporting the load via rollers or tracks in the walking machines. In one example, the lifting assemblies are provided with separate longitudinal and lateral drive mechanisms independently operative for translating the load in either or both longitudinal and lateral directions.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.