Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract: A third generation general partnership program radio communication system or a universal mobile telephone system employs a wide band code division multiple access system. The codes in various incoming signals from different sources are identified by cross correlation using a code matched filter. A multiplexer, samples the signals from each of the P sources at P times the chip rate of the codes in the incoming signals. The mutliplexer time multiplexes the received signals and feeds them to single delay line consisting of N stages each having P elements. Each stage will thus store one sample from each of the P sources. A selected element in each stage has an output which feeds a corresponding input of a code matched filter dot-product adder chain to enable a cross-correlation to be established for each incoming signal in turn.

Abstract: An editing program establishes communication with a remote computer using an Internet protocol, downloads a web page containing one or more imported images and displays the web page on a user interface. As the user moves a cursor over an imported image, its appearance may change. The user may select an imported image to edit directly from the displayed web page. In response to the user selecting an image, the editing program presents the image in an editing interface for modification by the user. The image may then be saved back to its original location according to write access permissions.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: A method of recovering transmitted symbols in a receiver of a spread spectrum system, comprising: receiving a signal including multi-path components associated with transmitted symbols; de-spreading successive separate portions of the received signal to provide a symbol estimate based on each multipath component, wherein the de-spreading step comprises determining at least one partial estimate of at least one transmitted symbol for an at least one partial multi-path component contained in a separate portion; and summing the partial estimates of separate portions corresponding to a same transmitted symbol.

Abstract: The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1): wherein R1 is —W-A1—W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21 etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Abstract: A multi-ribbed power transmission belt having longitudinal grooves and transverse grooves that form a plurality of cogs on the belt surface defined between adjacent transverse grooves is provided. The pitch lengths of the rows of cogs are randomized or sequenced over the entire length of the belt to reduce the noise of the belt as it travels about its associated pulleys. The ideal pitch pattern on a belt is variable, dependent upon the circumferential length of the belt. To create an optimized pitch sequence for belts of various circumferential lengths, a method of manufacture is employed wherein a portion of the pitch sequence of a shorter belt is incorporated within an optimized pitch sequence of a longer belt and both belts are manufactured from a single mold. The longer belt may contain cogs of various shapes intended to offset a range of frequencies and minimize noise generation.

Abstract: Method for controlling the level of tractive efforts in a train having a first locomotive at a head end of the train, constituting a lead locomotive, and a second locomotive positioned in the train behind the lead locomotive, constituting a remote locomotive, with the remote locomotive being configured to selectively operate in either of two modes of operation, such as a first mode in which the locomotive operates at a full tractive effort level of operation and a second mode in which the locomotive operates in a partial tractive effort level of operation producing a tractive effort which is less than the full tractive effort of the locomotive. The method allows selecting (e.g., at the lead locomotive) one of the two modes of operation for producing a level of tractive effort appropriate for conditions as the train moves along a length of track. The method further allows transmitting a signal indicative of the selected mode of operation from the lead locomotive to the remote locomotive.

Abstract: A method of in-band on-channel (IBOC) digital audio broadcasting (DAB) comprises the steps of providing an analog modulated carrier signal in a central frequency band of an AM radio channel, providing a first plurality of subcarriers in an upper sideband of the AM radio channel, providing a second plurality of subcarriers in a lower sideband of the AM radio channel, providing a third plurality of subcarriers in the central frequency band of the AM radio channel, modulating the first, second and third plurality of subcarriers with one or more digitally encoded signals, and transmitting the analog modulated signal and the first, second and third plurality of subcarriers, wherein the subcarriers in the third plurality of subcarriers that are positioned closest to the center of the channel are transmitted at higher power spectral densities than the subcarriers in the third plurality of subcarriers that are positioned farther from the center of the channel.

Abstract: The present invention relates to a method and system for accurately indexing print receiving media of various types. A media indexing system is provided that includes a roller capable of indexing a print receiving medium in response to an indexing operation. A relationship exists between a commanded indexing operation of the roller and resultant indexing of a first type of print receiving medium. A type of print receiving medium is supplied to the media indexing system. The type of the print receiving medium is generally identified. A desired amount by which the print receiving medium should be indexed is identified. A commanded indexing operation of the roller to index by the desired amount is modified based on the type of the print receiving medium and the relationship. The print receiving can be indexed by substantially the desired amount.

Abstract: A mode scrambler comprises an optical fiber adapter having a diffuser disposed between optical fiber mating ends of the optical fiber adapter. When a single mode optical signal is launched in the mode scrambler, the mode scrambler converts the single mode optical signal to a multimode optical signal that has a substantially even intensity distribution across the modes.

Abstract: An image processing application employs the concept of integral pre-multiplied alpha channel, and combines the techniques of multi-resolution representation, graph-structured representation, and automatic and intelligent data type conversion in order to permit a computer user to mix and manipulate both raster and vector based images in a single user interface while remaining unaware of the different data types underlying the images.

Abstract: A device for adjusting the position of a lens along an optical axis of the lens. The device has a lens housing for carrying the lens and a first knob positioned to rotate about the lens housing. A second knob is cooperatively threaded to the first knob such that rotation of the first knob relative to the second knob causes axial movement of the lens housing along the optical axis. A coupler couples the lens housing to the second knob to prevent the lens housing from rotating relative to the second knob when the first knob is rotated.

Abstract: Method and communication system for a railroad train having at least one locomotive for automatically adjusting the communication system to provide effective communication of command data to control operation of the locomotive are provided. The system includes a transceiver on the locomotive. The system further includes at least one transceiver remote from the locomotive. A database may be provided for storing data relative to a plurality of communication schemes available to the communication system. A first monitor may be used for sensing a parameter indicative of the quality of the communications between the transceivers when the transceivers are operating under a first one of the available communication schemes and generating data indicative of communications quality.

Abstract: The invention discloses an electrical machine, in particular a brushless synchronous motor that has a stator (14) and a rotor (12) with salient poles (18) disposed distributed over its circumference, each of which poles has an enclosed permanent magnet (11) and a pole shoe (19) that extends radially outward from the permanent magnet and defines an air gap (13) between the stator (14) and rotor (12). In order to achieve a low cogging torque and a low torque undulation, the pole shoes (19) are embodied as magnetically anisotropic, with a preferred direction of the greater magnetic conductivity extending parallel to the radial salient pole axis.

Abstract: An image processing application employs the concept of integral pre-multiplied alpha channel, and combines the techniques of multi-resolution representation, graph-structured representation, and automatic and intelligent data type conversion in order to permit a computer user to mix and manipulate both raster and vector based images in a single user interface while remaining unaware of the different data types underlying the images.

Abstract: A method and apparatus for producing an injection moulded plastics article comprises introducing a supply of plastics material (20) into a mould space (13), supplying a first stream of pressurised fluid into the molten plastics material to form a fluid containing cavity (25) therein, maintaining fluid pressure in the cavity until the plastics material can sustain the form dictated by the mould surface. During the step of maintaining fluid pressure in the cavity, at least a portion of the first stream of pressurised fluid is vented or allowed to vent from the cavity, and simultaneously a second stream of pressurised fluid from a second source (26; 40; 41) is supplied to the cavity, which second stream replaces that portion of the first stream which has vented from the cavity.

Abstract: A multi-ribbed power transmission belt longitudinal grooves and transverse grooves that form a plurality of cogs on the belt surface defined between adjacent transverse grooves. The pitch lengths of the rows of cogs are randomized or sequenced over the entire length of the belt to reduce the noise of the belt as it travels about its associated pulleys. The ideal pitch pattern on a belt is variable, dependent upon the circumferential length of the belt. To create an optimized pitch sequence for belts of various circumferential lengths, a method of manufacture is employed wherein a portion of the pitch sequence a shorter belt is incorporated within an optimized pitch sequence of a longer belt and both belts are manufactured from a single mold. The longer belt may contain cogs of various shapes intended to offset a range of frequencies and minimize noise generation.

Abstract: A method for extracting feature information from product images using multivariate image analysis (MIA) to develop predictive models for organoleptic and other feature content and distribution on the imaged product. The imaging system is used to monitor product quality variables in an on-line manufacturing environment. The method may also be integrated into a closed-loop feedback control system in automated systems.

Abstract: A global data sharing environment and data sharing proxy agent for multiple application instances in an object oriented processing system are disclosed. In response to an object in an application instance calling a data storage method, a local data sharing environment is generated that corresponds to the requesting object's application instance. As a data storage or retrieval method is processed, data is stored in or retrieved from the local data sharing environment. Data can also be shared between objects in separate application instances using the global data sharing environment.