Abstract: A diagnostic system for measuring acceleration of a piston of a reciprocating hammer is disclosed. The diagnostic system may include a magnet configured to induce, via electromagnetic induction and based on a movement of the piston, an electric current in a conductor. The diagnostic system may include a capacitor electrically coupled to the conductor and configured to store electric power based on the electric current induced by the magnet. The diagnostic system may include an accelerometer configured to measure an acceleration of the piston. The diagnostic system may include a communication device powered by the capacitor and configured to output a signal that identifies the acceleration measured by the accelerometer.

Abstract: A tool for demolishing a column, including a tool frame defining an interior work space. The interior work space is sized and shaped to at least partially surround a portion of the column. A support frame is disposed in the interior work space of the tool frame, the support frame including a tool support that is displaceable within the interior work space. A milling tool is rotatably disposed on the support frame and displaceable therewith to engage the column when the tool frame is positioned around the portion of the column. A hydraulic cylinder is attached between the tool frame and the support frame and configured to forcibly displace the support frame and milling tool within the interior work space. A motor is configured to rotate the milling tool.

Abstract: A piston for a hydraulic hammer assembly is provided. The piston may include an elongate member extending from a distal end to a proximal end and having a first outer diameter, a flange disposed on the elongate member and having a second outer diameter greater than the first outer diameter, and a non-ferrous shoe radially disposed on the flange.

Abstract: A tool for demolishing a column, including a tool frame defining an interior work space. The interior work space is sized and shaped to at least partially surround a portion of the column. A support frame is disposed in the interior work space of the tool frame, the support frame including a tool support that is displaceable within the interior work space. A milling tool is rotatably disposed on the support frame and displaceable therewith to engage the column when the tool frame is positioned around the portion of the column. A hydraulic cylinder is attached between the tool frame and the support frame and configured to forcibly displace the support frame and milling tool within the interior work space. A motor is configured to rotate the milling tool.

Abstract: A damping system for a hydraulic hammer is disclosed. The hydraulic hammer includes a housing and a mounting bracket disposed on the housing. The damping system includes an expandable bladder positioned between the power cell and the mounting bracket. The expandable bladder is configured to receive a supply of pressurized fluid and store a threshold volume of pressurized fluid therein. The damping system includes a plurality of sensors for detecting one or more parameters related to operating conditions of the hydraulic hammer. The damping system includes a controller disposed in communication with the sensors. The controller is configured to receive one or more inputs indicative of the parameters from the sensors to determine a threshold volume of pressurized fluid to be maintained in the expandable bladder. The controller is configured to supply the threshold volume of pressurized fluid to the expandable bladder during an operation of the hydraulic hammer.

Abstract: A diagnostic system for measuring acceleration of a piston of a reciprocating hammer is disclosed. The diagnostic system may include a magnet configured to induce, via electromagnetic induction and based on a movement of the piston, an electric current in a conductor. The diagnostic system may include a capacitor electrically coupled to the conductor and configured to store electric power based on the electric current induced by the magnet. The diagnostic system may include an accelerometer configured to measure an acceleration of the piston. The diagnostic system may include a communication device powered by the capacitor and configured to output a signal that identifies the acceleration measured by the accelerometer.

Abstract: A variable damping system for a power cell of a hydraulic hammer is disclosed. The hydraulic hammer has a housing and a mounting bracket disposed on a top side of the housing. The variable damping system includes an expandable bladder that is positioned between the power cell and an underside of the mounting bracket. The expandable bladder is configured to receive a supply of pressurized fluid and maintain a pre-determined volume of pressurized fluid therein.

Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Abstract: Provided herein are nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. In one aspect of the invention, the nucleic acids encode provides In a preferred embodiment, the invention nucleic acids encode MNDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. The disclosed nucleic acids are also useful as probes, thus enabling those skilled in the art, to identify and isolate related human receptor subunits. Functional glutamate receptors can be assembled, in accordance with the present invention, from a plurality of one type of NMDA receptor subunit protein (homomeric) or from a mixture of two or more types of subunit proteins (heteromeric). Also provided are methods for using the disclosed receptor subunits to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.

Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.

Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.

Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.

Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.

Abstract: Methods for identifying compounds which modulate the activity of human neuronal nicotinic acetylcholine receptors are provided. Invention methods employ DNAs encoding alpha and beta subunits of human neuronal nicotinic acetylcholine receptors, and the polypeptides encoded thereby. Test cells useful for conducting invention assays include mammalian and amphibian cells containing said DNA. Various combinations of subunits (i.e., one or more &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and &agr;7 subunits in combination with &bgr;2, &bgr;3 and/or &bgr;4 subunits) can be employed for the invention assays.

Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.

Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.

Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.