Patents by Inventor Steven B. Ellis

Steven B. Ellis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 6303753
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 16, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human calcium channel compositions and methods
    Patent number: 6096514
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 1, 2000
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Recombinant human calcium channel .beta..sub.4 subunits
    Patent number: 6090623
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the .alpha..sub.1A-1, .alpha..sub.1A-2, .alpha..sub.1E-1, .alpha..sub.1C-2, .alpha..sub.1E-3, .beta..sub.3-1, .beta..sub.2C, .beta..sub.2D, .beta..sub.2E and .beta..sub.4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: July 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue
  • Human n-methyl-d-aspartate receptor type 1 subunits, DNA encoding same and uses therefor
    Patent number: 6033865
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A and NMDAR2C subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 7, 2000
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw
  • DNA and mRNA encoding an .alpha..sub.4 subunit of human neuronal nicotinic acetylcholine receptor and cells transformed with same
    Patent number: 6022704
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 8, 2000
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Methods for identifying compounds that modulate the activity of human N-methyl-D-aspartate receptors
    Patent number: 5985586
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 16, 1999
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw, Chin-Chun Lu
  • Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    Patent number: 5910582
    Abstract: Nucleic acid encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: June 8, 1999
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Assays of cells expressing human calcium channels containing .alpha..sub.1 .beta. subunits
    Patent number: 5876958
    Abstract: Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: March 2, 1999
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1, .beta.-.sub.2, and .beta.-.sub.4 subunits, and assays using cells that express the subunits
    Patent number: 5874236
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.-and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: February 23, 1999
    Assignee: Sibia Neurosciences. Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human calcium channel .alpha.-1C/.alpha.-1D, .alpha.-2, .beta.-1, and .gamma.subunits and cells expressing the DNA
    Patent number: 5851824
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: December 22, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human calcium channel .alpha..sub.1, .alpha..sub.2, and .beta. subunits and assays using them
    Patent number: 5846757
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: December 8, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Human neuronal nicotinic acetylcholine receptor and cells transformed with same DNA and mRNA encoding an--subunit of
    Patent number: 5837489
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .beta..sub.7 subunits) are provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 17, 1998
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Methods for identifying compounds that modulate metabotropic glutamate receptor activity
    Patent number: 5807689
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 15, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Lorrie Daggett, Steven B. Ellis, Chen Liaw, Aaron Pontsler, Edwin C. Johnson, Stephen D. Hess
  • DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor alpha-2 subunit and cells transformed with same
    Patent number: 5801232
    Abstract: DNA encoding human neuronal nicotinic acetylcholine receptor .alpha..sub.2 subunits, mammalian and amphibian cells containing said DNA, and methods for producing such subunits are provided. In addition, combinations of subunits (i.e., .alpha..sub.2, plus .alpha..sub.1, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits) are provided.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: September 1, 1998
    Assignee: SIBIA Neuroscience, Inc.
    Inventors: Kathryn J. Elliott, Steven B. Ellis, Michael M. Harpold
  • Human calcium channel compositions and methods
    Patent number: 5792846
    Abstract: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 11, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Cells expressing calcium channel .alpha.2 subunit-encoding DNA, optionally with a reporter gene for screening assays
    Patent number: 5618720
    Abstract: [DNAs] DNA molecules encoding mammalian calcium channel a.sub.1 and a.sub.2 subunits are provided. The [DNAs] DNA molecules are used to transform host cells which may also contain a reporter gene, the transcription of which is responsive to an ion or molecule capable of entering the cell through a calcium channel.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: April 8, 1997
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Steven B. Ellis, Mark E. Williams, Michael M. Harpold, Arnold Schwartz, Jean Sartor, Robert Brenner
  • Nucleic acids encoding human metabotropic glutamate receptors
    Patent number: 5521297
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: May 28, 1996
    Assignee: Salk Institute Biotechnology/Industrial Associates
    Inventors: Lorrie Daggett, Steven B. Ellis, Chen Liaw, Aaron Pontsler
  • Assays for agonists and antagonists of recombinant human calcium channels
    Patent number: 5429921
    Abstract: Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: July 4, 1995
    Assignee: The Salk Institute Biotechnology/Industrial Assoc. Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Daniel H. Feldman, Ann F. McCue, Robert Brenner
  • Calcium channel .alpha.-2 subunit DNAs and cells expressing them
    Patent number: 5407820
    Abstract: Calcium channel .alpha..sub.1 -subunit and .alpha..sub.2 -subunit-encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: April 18, 1995
    Assignee: The Salk Institute Biotechnology/Industrial Associates, Inc.
    Inventors: Steven B. Ellis, Mark E. Williams, Michael M. Harpold, Arnold Schwartz, Robert Brenner
  • Calcium channel compositions and methods
    Patent number: 5386025
    Abstract: Calcium channel .gamma.-subunit-encoding cDNAs, and related compositions and methods, are provided.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: January 31, 1995
    Assignee: The Salk Institute Biotechnology/Industrial Associates
    Inventors: Scott D. Jay, Steven B. Ellis, Michael M. Harpold, Kevin P. Campbell