Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.

Abstract: A consumption probability metric may be generated for a media asset. An aggregated forecast predicting user consumption of a media asset is received. A plurality of probabilities, each corresponding to a user of a plurality of users, is received, each indicating how likely a respective user is to consume the media asset. A weight for the plurality of users is calculated representing a ratio of the total number of users to a number of users in the plurality of users. A disaggregated forecast predicting user consumption of a media asset is determined based on the weight for the plurality of users and the plurality of probabilities. A modification factor is computed based on the aggregated forecast and the disaggregated forecast. A metric is generated that includes a plurality of user identifiers associated with the plurality of users and a plurality of modified probabilities each modified by the modification factor.

Abstract: The present technology is directed to extraction devices, systems, and methods for controllably withdrawing and transferring fluid samples, such as blood, from a sample collection container to a testing device. For example, some embodiments of the present technology provide fluid extraction devices that include a fluid control module, a housing containing a receiving element and a suction element, and an actuator. To transfer blood from a sample collection container to a testing device, a user places the sample collection container over the receiving element and inserts the testing device into an outlet of the fluid control module. The user then pushes a lever or otherwise actuates the actuator, which automatically withdraws a predetermined volume of blood from the sample collection container and transfers it to the testing device positioned at the outlet of the fluid control module.

Abstract: A consumption probability metric may be generated for a media asset. An aggregated forecast predicting user consumption of a media asset is received. A plurality of probabilities, each corresponding to a user of a plurality of users, is received, each indicating how likely a respective user is to consume the media asset. A weight for the plurality of users is calculated representing a ratio of the total number of users to a number of users in the plurality of users. A disaggregated forecast predicting user consumption of a media asset is determined based on the weight for the plurality of users and the plurality of probabilities. A modification factor is computed based on the aggregated forecast and the disaggregated forecast. A metric is generated that includes a plurality of user identifiers associated with the plurality of users and a plurality of modified probabilities each modified by the modification factor.

Abstract: Fluidic devices, systems, and methods for analyzing an analyte are described. In an embodiment, the fluidic devices include a housing defining a lysis chamber shaped to receive a biological sample; a lysis buffer storage chamber disposed within the housing and carrying a lysis buffer configured to lyse cells of the biological sample; a cap configured to cooperatively couple to the housing; a compressor configured to compress the lysis buffer storage chamber and expel the lysis buffer from the lysis buffer storage chamber and into the lysis chamber when the cap is uncoupled from the housing; and a porous membrane in selective fluidic communication with the lysis chamber.

Abstract: An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device.

Abstract: A consumption probability metric may be generated for a media asset. An aggregated forecast predicting user consumption of a media asset is received. A plurality of probabilities, each corresponding to a user of a plurality of users, is received, each indicating how likely a respective user is to consume the media asset. A weight for the plurality of users is calculated representing a ratio of the total number of users to a number of users in the plurality of users. A disaggregated forecast predicting user consumption of a media asset is determined based on the weight for the plurality of users and the plurality of probabilities. A modification factor is computed based on the aggregated forecast and the disaggregated forecast. A metric is generated that includes a plurality of user identifiers associated with the plurality of users and a plurality of modified probabilities each modified by the modification factor.

Abstract: A medical device for wound closure, e.g., repairing perforations and tissue wall defects. The medical device has a barbed elongate body and an outer member. The medical device may further include a foam structure. The medical device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.

Abstract: The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fins-related tyrosine kinase 3 (Fltt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1 alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.

Abstract: A consumption probability metric may be generated for a media asset. An aggregated forecast predicting user consumption of a media asset is received. A plurality of probabilities, each corresponding to a user of a plurality of users, is received, each indicating how likely a respective user is to consume the media asset. A weight for the plurality of users is calculated representing a ratio of the total number of users to a number of users in the plurality of users. A disaggregated forecast predicting user consumption of a media asset is determined based on the weight for the plurality of users and the plurality of probabilities. A modification factor is computed based on the aggregated forecast and the disaggregated forecast. A metric is generated that includes a plurality of user identifiers associated with the plurality of users and a plurality of modified probabilities each modified by the modification factor.

Abstract: The present technology is directed to extraction devices, systems, and methods for controllably withdrawing and transferring fluid samples, such as blood, from a sample collection container to a testing device. For example, some embodiments of the present technology provide fluid extraction devices that include a fluid control module, a housing containing a receiving element and a suction element, and an actuator. To transfer blood from a sample collection container to a testing device, a user places the sample collection container over the receiving element and inserts the testing device into an outlet of the fluid control module. The user then pushes a lever or otherwise actuates the actuator, which automatically withdraws a predetermined volume of blood from the sample collection container and transfers it to the testing device positioned at the outlet of the fluid control module.

Abstract: A consumption probability metric may be generated for a media asset. An aggregated forecast predicting user consumption of a media asset is received. A plurality of probabilities, each corresponding to a user of a plurality of users, is received, each indicating how likely a respective user is to consume the media asset. A weight for the plurality of users is calculated representing a ratio of the total number of users to a number of users in the plurality of users. A disaggregated forecast predicting user consumption of a media asset is determined based on the weight for the plurality of users and the plurality of probabilities. A modification factor is computed based on the aggregated forecast and the disaggregated forecast. A metric is generated that includes a plurality of user identifiers associated with the plurality of users and a plurality of modified probabilities each modified by the modification factor.

Abstract: Methods and systems are provided for determining advertising reach based on machine learning. In particular, a reach calculator is provided to determine reach for advertisement campaigns in real time through the use of machine learning. The reach calculator increases the speed at which reach calculations can be done by using a trained machine learning model and a set of aggregated features as opposed to using a direct calculation approach that directly analyzes a massive amount of user data.

Abstract: The present disclosure includes systems and a method for in situ application of a surgical patch during minimally invasive surgery. The method includes the steps of inserting a surgical patch into a bag; transferring a polymeric bag containing a hemostatic patch into a body cavity; removing the surgical patch from the polymeric bag while the polymeric bag is within the body cavity; and applying the surgical patch to a tissue within the body cavity.

Abstract: The detector has a first optical smoke detector having a first smoke detector light source arranged for emitting a first beam of light and a first scattered light sensor positioned to detect light from the first beam which is scattered by smoke present within a detection zone; a second optical smoke detector having a second smoke detector light source arranged for emitting a second beam of light and a second scattered light sensor positioned to detect light from the second beam which is scattered by smoke present within the detection zone; and an object proximity detector to detect an object in the detection zone.

Abstract: The present invention relates to systems and methods for testing nodes within a fire detector system. The system comprises an aerial platform, such as a drone, and a base station in communication with the aerial platform and a fire control panel. The base station, in conjunction with the control panel, determines which of the nodes are to be tested and the aerial platform positions itself such that it is able to test the selected nodes.

Abstract: The detector has a first optical smoke detector having a first smoke detector light source arranged for emitting a first beam of light and a first scattered light sensor positioned to detect light from the first beam which is scattered by smoke present within a detection zone; a second optical smoke detector having a second smoke detector light source arranged for emitting a second beam of light and a second scattered light sensor positioned to detect light from the second beam which is scattered by smoke present within the detection zone; and an object proximity detector to detect an object in the detection zone.