Abstract: In a networked data system, a discovery protocol enables clients to establish connections to one a plurality of database servers to utilize a distributed connection service. The service manages connections between application servers, i.e. clients, and databases. An initial request from the client is received by a load balancer. The load balancer responds to the client by identifying an assigned connection to one of the database servers based on load considerations. The client sends a secondary request directly to the assigned connection, bypassing the load balancer. The service establishes a persistent link on the assigned connection and assigns a time-to-live (TTL), during which the service connects data requests to the databases. Upon expiration of the TTL, the service completes a next data request received, then notifies the client that the connection is no longer valid, thereby requiring a new connection through the load balancer and rebalancing system traffic.

Abstract: A method of forming an optical fiber preform includes: flowing a silicon halide and an oxidizer inside of a substrate tube, wherein a molar ratio of the silicon halide to the oxidizer is from about 1.5 to about 5.0; applying a plasma to the substrate tube to heat the substrate tube to a temperature of from about 1000° C. to about 1700° C.; and depositing silica glass comprising a halogen inside the substrate tube.

Abstract: The present disclosure relates to the reversal of T cell exhaustion using aplysiatoxin analogs or PKC theta agonist compounds for anti-cancer immunotherapy. The treatment with aplysiatoxin analogs or PKC theta agonist compounds improve the anti-tumour activity of a T cell, inducing a NFAT-dependent T cell activation, increasing the pool of immune-checkpoint inhibitor responsive T cells, increasing lymphocyte infiltration and increasing the population of activated CD4+ and/or CD8+ cells. The methods of the present disclosure provide treatment of tumors and infections.

Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

Abstract: Systems and methods for are provided for predicting impending failure of a database and preemptively initiating mitigating failover actions, for example by shedding connections or redirecting connection requests to an alternate database that can fulfill resources being requested. In an example embodiment, to detect a slow or unstable database, connection wait times are monitored over a rolling window of time intervals, a quantity of intervals in which at least one excessive wait time event occurred are counted during the time window, and if the quantity exceeds a threshold, the database is deemed unavailable, thereby triggering connection adjustments.

Abstract: Defects are identified in a pre-production version of an application. Input used to test the pre-production version is derived from input received by a production version of the application. Input to the production version may be selectively filtered and/or amplified before being provided as test input to the pre-production version. In this way, the makeup and rate of the test input can be controlled while maintaining the character, pattern, and unpredictable nature of real-world input. Defects may be identified when the test input causes the pre-production version to crash, hang, write to an error log, or otherwise manifest or report a malfunction. In addition to identifying defects, filtered and amplified input may also be used to perform regression testing, load testing, performance testing, etc.

Abstract: A processing system includes an interconnect, a master processing device including processing cores coupled to the interconnect, a hypervisor coupled to the interconnect and configured to allocate the processing cores to one or more virtual machines, domain configuration information including a domain identifier for each of the one or more virtual machines, remote peripheral devices coupled to the interconnect, and a domain access controller coupled to the interconnect and configured to receive the domain identifiers for the remote peripherals directly from the hypervisor through the interconnect.

Abstract: Introduced here are methods, apparatuses, and systems for mitigating the contact pressure applied to a human body by the surface of an object, such as a chair, bed, or table. A pressure-mitigation apparatus can include a series of chambers whose pressure can be individually varied. When placed between a patient and a contact surface, a controller can vary the contact pressure on the human body by controllably inflating one or more chambers, deflating one or more chambers, or any combination thereof. By monitoring the pressure in each chamber over time, the controller can also gain an enhanced understanding of movement(s) performed by the human body when positioned on the pressure-mitigation apparatus.

Abstract: Introduced here are methods, apparatuses, and systems for mitigating the contact pressure applied to a human body by the surface of an object, such as a chair, bed, or table. A pressure-mitigation apparatus can include a series of chambers whose pressure can be individually varied. When placed between a patient and a contact surface, a controller can vary the contact pressure on the human body by controllably inflating one or more chambers, deflating one or more chambers, or any combination thereof. By monitoring the pressure in each chamber over time, the controller can also gain an enhanced understanding of movement(s) performed by the human body when positioned on the pressure-mitigation apparatus.

Abstract: Systems and methods for are provided for predicting impending failure of a database and preemptively initiating mitigating failover actions, for example by shedding connections or redirecting connection requests to an alternate database that can fulfill resources being requested. In an example embodiment, to detect a slow or unstable database, connection wait times are monitored over a rolling window of time intervals, a quantity of intervals in which at least one excessive wait time event occurred are counted during the time window, and if the quantity exceeds a threshold, the database is deemed unavailable, thereby triggering connection adjustments.

Abstract: A component for a gas turbine engine includes a trailing edge tip corner that at least partially defines a trailing edge cavity and a multiple of corner features within the trailing edge cavity, the multiple of corner features splayed along the trailing edge tip corner.

Abstract: Preparation of halogen-doped silica is described. The preparation includes doping silica with high halogen concentration, sintering halogen-doped silica to a closed-pore state, and subjecting the closed-pore silica body to a thermal treatment process and/or a pressure treatment process. The temperature of thermal treatment is sufficiently high to facilitate reaction of unreacted doping precursor trapped in voids or interstices of the glass structure, but is below temperatures conducive to foaming. Core canes or fibers drawn from halogen-doped silica subjected to the thermal treatment and/or pressure treatment show improved optical quality and possess fewer defects. The thermal treatment and/or pressure treatment is particularly advantageous when used for silica doped with high concentrations of halogen.

Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

Abstract: Introduced here are pressure-mitigation apparatuses for mitigating the pressure applied to a human body by the support surface of an object. The pressure-mitigation apparatus can include a series of chambers that can be individually controlled to vary the pressure therein. By varying the chamber pressure, the main point of pressure applied by the support surface to the human body may be moved across the surface of the human body. An attachment apparatus may be used to securely adhere the pressure-mitigation apparatus to the support surface.

Abstract: A component for a gas turbine engine includes, among other things, an airfoil that includes a pressure sidewall and a suction sidewall that meet together at both a leading edge and a trailing edge, the airfoil extending radially from a platform to a tip, a tip pocket formed in the tip and terminating prior to the trailing edge, and one or more heat transfer augmentation devices formed in the tip pocket.

Abstract: Preparation of halogen-doped silica is described. The preparation includes doping silica with high halogen concentration and sintering halogen-doped silica to a closed-pore state in a gas-phase environment that has a low partial pressure of impermeable gases. Impermeable gases are difficult to remove from halogen-doped fiber preforms and lead to defects in optical fibers drawn from the preforms. A low partial pressure of impermeable gases in the sintering environment leads to a low concentration of impermeable gases and a low density of gas-phase voids in densified halogen-doped silica. Preforms with fewer defects result.

Abstract: A mobile application development environment may be maintained in association with a computing platform. A request to produce a first mobile application with a first security policy may be processed. The first mobile application may be automatically produced. The first security policy may be integrated with the first mobile application during creation of the first mobile application. The first mobile application may be provided to a mobile application provider. The first security policy may be included in the first mobile application when the first mobile application is downloaded from the mobile application provider.