Abstract: An on-demand ecosystem (ODE) computing device for integrating on-demand delivery services with purchase transactions is provided. The ODE computing device receives item data from a registered merchant, and receives availability data from at least one registered carrier. The ODE computing device further provides a searchable interface that enables a user to search for item data from the registered merchant, and receives a selected item from the user via the searchable interface. The selected item is offered for sale by the registered merchant and includes a selected pick-up location. The selected item is to be delivered to the user from the selected pick-up location. The ODE computing device also allows either the registered merchant or the user to select one of the at least one registered carriers, and processes a payment transaction for the selected item including an item price and a delivery fee.

Abstract: Systems and methods for are provided for predicting impending failure of a database and preemptively initiating mitigating failover actions, for example by shedding connections or redirecting connection requests to an alternate database that can fulfill resources being requested. In an example embodiment, to detect a slow or unstable database, connection wait times are monitored over a rolling window of time intervals, a quantity of intervals in which at least one excessive wait time event occurred are counted during the time window, and if the quantity exceeds a threshold, the database is deemed unavailable, thereby triggering connection adjustments.

Abstract: In a networked data system, a discovery protocol enables clients to establish connections to one a plurality of database servers to utilize a distributed connection service. The service manages connections between application servers, i.e. clients, and databases. An initial request from the client is received by a load balancer. The load balancer responds to the client by identifying an assigned connection to one of the database servers based on load considerations. The client sends a secondary request directly to the assigned connection, bypassing the load balancer. The service establishes a persistent link on the assigned connection and assigns a time-to-live (TTL), during which the service connects data requests to the databases. Upon expiration of the TTL, the service completes a next data request received, then notifies the client that the connection is no longer valid, thereby requiring a new connection through the load balancer and rebalancing system traffic.

Abstract: Bromine doping of silica glass is demonstrated. Bromine doping can be achieved with SiBr4 as a precursor. Bromine doping can occur during heating, consolidation or sintering of a porous silica glass body. Doping concentrations of bromine increase with increasing pressure of the doping precursor and can be modeled with a power law equation in which doping concentration is proportional to the square root of the pressure of the doping precursor. Bromine is an updopant in silica and the relative refractive index of silica increases approximately linearly with doping concentration. Bromine can be used as a dopant for optical fibers and can be incorporated in the core and/or cladding regions. Core doping concentrations of bromine are sufficient to permit use of undoped silica as an inner cladding material in fibers having a trench in the refractive index profile. Co-doping of silica glass with bromine and chlorine is also demonstrated.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Technologies are disclosed for monitoring network traffic using traffic mirroring. According to some examples, traffic mirroring allows customers to monitor traffic at different sources within a VPC. For example, a source may be any Elastic Network Interface (ENI) in their VPC, including elastic network interfaces (ENIs) on virtual machine instances, Network Address Translation (NAT) Gateways, Load Balancers, VPC endpoints, Internal Gateways, Transit Gateways, and more. Filters can be utilized to determine the network traffic to mirror. A customer may also configure to monitor real-time traffic with a monitoring appliance of their choice. With traffic mirroring, data traffic may be identified and sent to one or more target devices. Customers may monitor traffic within a VPC for content inspection, forensic analysis, troubleshooting, record keeping, and the like.

Abstract: Apparatuses and methods for processing optical fiber preforms are disclosed. According to one aspect, an apparatus generally includes a furnace body and a muffle disposed within the furnace body. A space between the muffle and the furnace body defines a first interior volume. The muffle defines a second interior volume sealed from the first interior volume. An annulus gas is supplied to the first interior volume and a process gas is supplied to the second interior volume. A differential pressure gauge is coupled to the interior volumes. A flow controller is coupled to at least one of the gas sources and to the differential pressure gauge. The flow controller receives a differential pressure signal from the differential pressure gauge and adjusts a flow of a gas such that the pressure differential between the first interior volume and the second interior volume is minimized.

Abstract: A transfer port system is described herein having a port ring configured for placement in a barrier wall, where the port ring defines a port opening and an interface insert receptacle. The interface insert receptacle is configured to (1) interchangeably receive and (2) releasably fasten to each of a first interface insert and a second interface insert. The first interface insert defines a first set of mating features and the second interface insert defines a second set of mating features that are configured to form a seal with different mounting assemblies than the first mating features. The first set of mating features has a first geometry that is different than a second geometry of the second set of mating features.

Abstract: A pivoting turbine vane has an airfoil, an inner bearing race and an outer bearing race, with the inner and outer bearing races on a pivot axis of the pivoting turbine vane. There are cooling air passages through at least one of the inner and outer bearing races to provide cooling air from a remote facing face of at least one of the inner and outer bearing races to an airfoil facing face of at least one of the inner and outer bearing races. A turbine section is also disclosed.

Abstract: In a featured embodiment, a lost core assembly includes a ceramic component having a tapered shape in a radial direction. A refractory metal component extends radially from the ceramic core component. A method of molding a gas turbine engine component is also disclosed.

Abstract: An airfoil includes pressure and suction side walls that extend in a chord-wise direction between leading and trailing edges. The pressure and suction side walls extend in a radial direction to provide an exterior airfoil surface. A main-body core cooling passage is arranged between the pressure and suction walls in a thickness direction and extends radially toward a platform. A skin core cooling passage is arranged in one of the pressure and suction side walls to form a hot side wall and a cold side wall. The hot side wall defines a portion of the exterior airfoil surface and the cold side wall defines a portion of the core passage. The skin core cooling passage is divided by a wall into two discrete first and second skin core cooling passages each supplied with cooling fluid from opposing sides.

Abstract: Disclosed herein are compounds, drug-conjugates thereof, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat a variety of conditions, diseases and ailments such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: A component for a gas turbine engine includes, among other things, an airfoil that includes a pressure sidewall and a suction sidewall that meet together at both a leading edge and a trailing edge, the airfoil extending radially from a platform to a tip, a tip pocket formed in the tip and terminating prior to the trailing edge, and one or more heat transfer augmentation devices formed in the tip pocket.

Abstract: Small-radius coated optical fibers having large mode field diameter and low bending losses. The coated fiber may have an outer radius of 110 ?m or less, while providing a mode field diameter of 9.0 ?m or greater and a bending loss when wrapped about a 15 mm mandrel of 0.5 dB/km or less at wavelength of 1550 nm. The coated fiber may have a mode field diameter of 9.2 ?m or greater and may have a bending loss at 1550 nm of 0.25 dB/km or less when wrapped about a 20 mm mandrel or a bending loss at 1550 nm of 0.02 dB/km or less when wrapped about a 30 mm mandrel.

Abstract: A gas turbine engine component comprises an airfoil with a suction side and pressure side extending from a leading edge to a trailing edge. There are a plurality of cooling holes adjacent the leading edge, with the cooling holes having a non-circular shape, with a longer dimension and a smaller dimension. The airfoil defines a radial direction from a radially outer end to a radially inner end, and radially outer of the cooling holes spaced toward the radially outer end, which have the longer dimension extending closer to parallel to the radial direction. Radially inner cooling holes closer to the radially inner end having the longer dimension extend to be closer to perpendicular relative to the radial direction compared to the radially outer cooling holes.

Abstract: Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Abstract: A combustor for a gas turbine engine includes a combustor shell having a shell opening therethrough, a combustor panel having a stud attached thereto, the stud extending through the shell opening. The stud includes a standoff to define an intermediate passage between the combustor shell and the combustor panel. A retainer is attached to the stud. A washer surrounds the stud and is positioned between the retainer and the combustor shell. The washer at least partially defines a cooling flow passage configured to direct a cooling airflow through the shell opening to impinge the cooling flow on at least one of the stud or the standoff.

Abstract: A component for a gas turbine engine includes a root with a neck that extends into a fir tree with at least one tooth, the root includes a feed passage in communication with a multiple of cooling passages that extend through the neck and fir tree.

Abstract: A vane ring for a gas turbine engine component includes a multiple of vanes that extend between an inner vane platform and an outer vane platform, each of the multiple of vanes contains an airfoil cooling circuit that receives cooing airflow through a feed passage located in the outer vane platform and an extension from the outer vane platform, the extension comprises a metering passage in communication with the feed passage.