Patents by Inventor Steven Bruce

Steven Bruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody Drug Conjugates
    Publication number: 20190119375
    Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
    Type: Application
    Filed: May 24, 2018
    Publication date: April 25, 2019
    Applicant: Novartis AG
    Inventors: Tinya Abrams, Steven Bruce Cohen, Jason Damiano, Clemens Dürr, Thomas Huber, Daniel Menezes, Kathy Miller, Katherine Rendahl, Jean-Michel Rene Rondeau
  • OPTICAL FIBER PREFORMS WITH HALOGEN DOPING
    Publication number: 20190119143
    Abstract: Preparation of halogen-doped silica is described. The preparation includes doping silica with high halogen concentration, sintering halogen-doped silica to a closed-pore state, and subjecting the closed-pore silica body to a thermal treatment process and/or a pressure treatment process. The temperature of thermal treatment is sufficiently high to facilitate reaction of unreacted doping precursor trapped in voids or interstices of the glass structure, but is below temperatures conducive to foaming. Core canes or fibers drawn from halogen-doped silica subjected to the thermal treatment and/or pressure treatment show improved optical quality and possess fewer defects. The thermal treatment and/or pressure treatment is particularly advantageous when used for silica doped with high concentrations of halogen.
    Type: Application
    Filed: October 19, 2018
    Publication date: April 25, 2019
    Inventors: Dana Craig Bookbinder, Steven Bruce Dawes, Richard Michael Fiacco, Ming-Jun Li, Pushkar Tandon
  • COOLING CONFIGURATIONS FOR COMBUSTOR ATTACHMENT FEATURES
    Publication number: 20190078787
    Abstract: A combustor panel may include an attachment feature. Because conventional attachment features of conventional combustor panels may be insufficiently cooled, the present disclosure provides various combustor configurations for reducing hotspots in the vicinity of attachment features and/or for providing cooling airflow to and in the vicinity of attachment features.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Applicant: UNITED TECHNOLOGIES CORPORATION
    Inventors: Benjamin D Bellows, Brandon W Spangler, David J Hyland, Dennis M Moura, James B Hoke, Ricardo Trindade, Stephen K Kramer, Steven Bruce Gautschi
  • COOLING CONFIGURATIONS FOR COMBUSTOR ATTACHMENT FEATURES
    Publication number: 20190078788
    Abstract: A combustor panel may include an attachment feature. Because conventional attachment features of conventional combustor panels may be insufficiently cooled, the present disclosure provides various combustor configurations for reducing hotspots in the vicinity of attachment features and/or for providing cooling airflow to and in the vicinity of attachment features.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Applicant: UNITED TECHNOLOGIES CORPORATION
    Inventors: Tracy A Propheter-Hinckley, Atul Kohli, Benjamin D Bellows, Dustin W Davis, James B Hoke, Stephen K Kramer, Steven Bruce Gautschi, Trevor Rudy
  • COOLING CONFIGURATIONS FOR COMBUSTOR ATTACHMENT FEATURES
    Publication number: 20190078785
    Abstract: A combustor panel may include an attachment feature. Because conventional attachment features of conventional combustor panels may be insufficiently cooled, the present disclosure provides various combustor configurations for reducing hotspots in the vicinity of attachment features and/or for providing cooling airflow to and in the vicinity of attachment features.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Applicant: UNITED TECHNOLOGIES CORPORATION
    Inventors: Tracy A. Propheter-Hinckley, Atul Kohli, Benjamin D. Bellows, Brandon W. Spangler, David J. Hyland, Dennis M. Moura, Dustin W. Davis, Mark F. Zelesky, Ricardo Trindade, Stephen K. Kramer, Steven Bruce Gautschi, Trevor Rudy
  • COOLING CONFIGURATIONS FOR COMBUSTOR ATTACHMENT FEATURES
    Publication number: 20190078786
    Abstract: A combustor panel may include an attachment feature. Because conventional attachment features of conventional combustor panels may be insufficiently cooled, the present disclosure provides various combustor configurations for reducing hotspots in the vicinity of attachment features and/or for providing cooling airflow to and in the vicinity of attachment features.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Applicant: UNITED TECHNOLOGIES CORPORATION
    Inventors: Tracy A. Propheter-Hinckley, Atul Kohli, Brandon W. Spangler, David J. Hyland, Dustin W. Davis, Ricardo Trindade, Stephen K. Kramer, Steven Bruce Gautschi
  • Low bend loss single mode optical fiber with bromine up-doped cladding
    Patent number: 10215915
    Abstract: According to embodiments, an optical fiber may include a core portion comprising an outer radius rC and a maximum relative refractive index ?Cmax. A cladding may surround the core portion and include a low-index trench and an outer cladding. The low index trench may surround the core portion and includes an outer radius rT and relative refractive index ?T. The outer cladding may surround and be in direct contact with the low-index trench. The outer cladding may be formed from silica-based glass comprising greater than 1.0 wt. % bromine and has a relative refractive index ?OC, wherein ?Cmax>?OC>?T. The optical fiber may have a cable cutoff of less than or equal to 1530 nm. An attenuation of the optical fiber may be less than or equal to 0.185 dB/km at a wavelength of 1550 nm.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: February 26, 2019
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Steven Bruce Dawes, Ming-Jun Li, Pushkar Tandon
  • Apparatus and method for air particle separation in a gas turbine engine
    Patent number: 10202903
    Abstract: A particle separator for removing particles in a flow of air is provided. The particle separator having: a conduit for directing air towards a curved section of the conduit; and a drum in fluid communication with the conduit proximate to the curved section of the conduit, wherein particles in the air travelling towards the curved section will contact a surface of the drum.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: February 12, 2019
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: Shayan Ahmadian, Steven Bruce Gautschi, Mark F. Zelesky
  • Flared crossovers for airfoils
    Patent number: 10190420
    Abstract: An airfoil according to an example of the present disclosure includes, among other things, an airfoil section having an external wall and an internal wall. The internal wall defines a reference plane extending in a spanwise direction along a surface of the internal wall, a first cavity and a second cavity separated by the internal wall, and a plurality of crossover passages within the internal wall and connecting the first cavity to the second cavity. Each of the plurality of crossover passages defines a passage axis. The passage axis of each of the plurality of crossover passages is arranged at a radial angle relative to a localized region of the reference plane such that the radial angle of at least some of the plurality of crossover passages differs in the spanwise direction.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: January 29, 2019
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: Christopher King, San Quach, Steven Bruce Gautschi
  • GAS TURBINE ENGINE COMPONENT COOLING CIRCUIT
    Publication number: 20190017390
    Abstract: A method of manufacturing a component for a gas turbine engine according to an exemplary aspect of the present disclosure includes forming the component with a first manufacturing technique to include a first cavity and a second cavity, and a microcircuit in fluid communication with the first cavity, the component including an outer wall and a ribbed portion or a bulged portion extending from the outer wall. The exemplary method includes forming a plunged hole with a second manufacturing technique different from the first manufacturing technique to intersect at least a portion of the microcircuit and extend into the ribbed portion or the bulged portion.
    Type: Application
    Filed: June 5, 2018
    Publication date: January 17, 2019
    Inventors: Tracy A. Propheter-Hinckley, Steven Bruce Gautschi, San Quach
  • Turbine airfoil and method of cooling
    Patent number: 10156144
    Abstract: An airfoil for use in a gas turbine engine is provided. The airfoil having: a pressure surface and a suction surface each extending axially from a leading edge to a trailing edge of the airfoil, at least one of the pressure surface, the suction surface, the leading edge and the trailing edge terminating at an edge of a tip section of the airfoil; a plurality of internal cooling channels located within the airfoil; and at least one cooling hole in fluid communication with at least one of the plurality of internal cooling channels, wherein the at least one cooling hole is aligned with an opening or diffuser that extends directly from the at least one cooling hole and wherein the opening or diffuser is formed in and extends through the edge of the tip section of the airfoil.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: December 18, 2018
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: San Quach, Steven Bruce Gautschi, Matthew A. Devore, Scott D. Lewis, Matthew S. Gleiner, Christopher King, Christopher Corcoran, David Donald Chapdelaine
  • Cooling hole arrangement for engine component
    Patent number: 10125614
    Abstract: A component for a gas turbine engine according to an exemplary aspect of this disclosure includes a surface having a plurality of cooling holes. The surface includes a first region and a second region each having a plurality of cooling holes. The cooling holes within the first region are arranged differently than the cooling holes in the second region.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 13, 2018
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: Dominic J. Mongillo, San Quach, Steven Bruce Gautschi, Brandon S. Donnell, Anita L. Tracy, Yafet Girma
  • Antibody drug conjugates
    Patent number: 10117953
    Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: November 6, 2018
    Assignee: Novartis AG
    Inventors: Tinya Abrams, Steven Bruce Cohen, Christie P. Fanton, Thomas Huber, Kathy Miller, Siew Ho Schleyer, Kathrin Ulrike Tissot-Daguette, Catrin Finner
  • ANTI-CANCER COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20180296688
    Abstract: Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.
    Type: Application
    Filed: September 27, 2016
    Publication date: October 18, 2018
    Inventors: Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
  • Gas turbine engine component cooling circuit
    Patent number: 10100646
    Abstract: A component for a gas turbine engine according to an exemplary aspect of the present disclosure includes, among other things, a body portion, a cooling circuit disposed within the body portion and including at least a first cavity and a microcircuit in fluid communication with the first cavity. A plunged hole intersects at least a portion of the microcircuit.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 16, 2018
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: Tracy A. Propheter-Hinckley, Steven Bruce Gautschi, San Quach
  • LOST CORE MOLDING CORES FOR FORMING COOLING PASSAGES
    Publication number: 20180281051
    Abstract: In a featured embodiment, a lost core assembly includes a ceramic component having a tapered shape in a radial direction. A refractory metal component extends radially from the ceramic core component. A method of molding a gas turbine engine component is also disclosed.
    Type: Application
    Filed: April 24, 2018
    Publication date: October 4, 2018
    Inventors: Lane Thornton, San Quach, Steven Bruce Gautschi
  • WASHER FOR COMBUSTOR ASSEMBLY
    Publication number: 20180283687
    Abstract: A combustor for a gas turbine engine includes a combustor shell having a shell opening therethrough, a combustor panel having a stud attached thereto, the stud extending through the shell opening. The stud includes a standoff to define an intermediate passage between the combustor shell and the combustor panel. A retainer is attached to the stud. A washer surrounds the stud and is positioned between the retainer and the combustor shell. The washer at least partially defines a cooling flow passage configured to direct a cooling airflow through the shell opening to impinge the cooling flow on at least one of the stud or the standoff.
    Type: Application
    Filed: March 31, 2017
    Publication date: October 4, 2018
    Inventors: Tracy A. Propheter-Hinckley, Mark F. Zelesky, Atul Kohli, Dustin W. Davis, Ricardo Trindade, Steven Bruce Gautschi, Brandon W. Spangler, Trevor Rudy, Benjamin Bellows, Dave J. Hyland, James B. Hoke, Stephen K. Kramer, Dennis M. Moura
  • NEAR INFRARED SHIELDING AND LASER-RESISTANT WINDOW
    Publication number: 20180273419
    Abstract: Near-infrared shielding includes a glass material. The shielding provides transmittance at wavelengths between 390 to 700 nm, but near infrared absorbing species are distributed throughout the glass material and the shielding blocks light in the near infrared range. Further, the glass material has a near zero or negative coefficient of thermal expansion, allowing the glass material to heat up when the shielding is blocking a near infrared laser, without expanding much.
    Type: Application
    Filed: October 4, 2017
    Publication date: September 27, 2018
    Inventors: Sezhian Annamalai, Steven Bruce Dawes, Carlos Alberto Duran, Jesse Kohl
  • AIRFOIL TIP POCKET WITH AUGMENTATION FEATURES
    Publication number: 20180274373
    Abstract: A component for a gas turbine engine includes, among other things, an airfoil that includes a pressure sidewall and a suction sidewall that meet together at both a leading edge and a trailing edge, the airfoil extending radially from a platform to a tip, a tip pocket formed in the tip and terminating prior to the trailing edge, and one or more heat transfer augmentation devices formed in the tip pocket.
    Type: Application
    Filed: June 1, 2018
    Publication date: September 27, 2018
    Inventors: San Quach, Tracy A. Propheter-Hinckley, Steven Bruce Gautschi
  • Drinking mug
    Patent number: D830776
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: October 16, 2018
    Assignee: Time On Target Holdings, LLC
    Inventors: David E. Lane, II, John Glenn Kerwood, Roy Luther Manley, Steven Bruce Willingham, Craig Brian Willingham