Patents by Inventor Steven C. Clark
Steven C. Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7622630Abstract: Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.Type: GrantFiled: August 27, 2004Date of Patent: November 24, 2009Assignee: AVEO Pharmaceuticals, Inc.Inventors: Joerg Heyer, Murray Robinson, William Rideout, III, Ronald Depinho, Steven C. Clark, Yinghui Zhou, Tyler Jacks, Ronan C. O'Hagan
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Patent number: 7361738Abstract: Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.Type: GrantFiled: June 28, 2005Date of Patent: April 22, 2008Assignee: Genetics Institute, Inc.Inventors: Katherine Turner, Steven C. Clark, Kenneth Jacobs, Rodney M. Hewick, Thomas G. Gesner
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Patent number: 7122633Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.Type: GrantFiled: February 5, 2003Date of Patent: October 17, 2006Assignees: The Wistar Institute, WyethInventors: Giorgio Trinchieri, Bice Perussia, Stanley F. Wolf, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
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Patent number: 7030223Abstract: Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.Type: GrantFiled: April 16, 2002Date of Patent: April 18, 2006Assignee: Genetics Institute LLCInventors: Katherine Turner, Steven C. Clark, Kenneth Jacobs, Rodney M. Hewick, Thomas G. Gesner
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Publication number: 20040044186Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.Type: ApplicationFiled: February 5, 2003Publication date: March 4, 2004Applicant: Wyeth and The Wistar InstituteInventors: Giorgio Trinchieri, Bice Perussia, Stanley F. Wolf, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
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Patent number: 6555658Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.Type: GrantFiled: August 9, 2001Date of Patent: April 29, 2003Assignees: Wyeth, The Wistar InstituteInventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
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Publication number: 20020137894Abstract: Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.Type: ApplicationFiled: April 16, 2002Publication date: September 26, 2002Applicant: Wyeth (as successor to Genetics Institute, Inc. / American Home Products)Inventors: Katherine Turner, Steven C. Clark, Kenneth Jacobs, Rodney M. Hewick, Thomas G. Gesner
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Publication number: 20020137898Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.Type: ApplicationFiled: August 9, 2001Publication date: September 26, 2002Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rondey Hewick, Michiko Kobayashi
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Patent number: 6433142Abstract: Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.Type: GrantFiled: September 10, 1991Date of Patent: August 13, 2002Assignee: Genetics Institute, LLCInventors: Katherine Turner, Steven C. Clark, Kenneth Jacobs, Rodney M. Hewick, Thomas G. Gesner
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Patent number: 6348191Abstract: IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.Type: GrantFiled: June 17, 1991Date of Patent: February 19, 2002Assignee: Genetics Institute, Inc.Inventors: Steven C. Clark, Gordon G. Wong, Paul Schendel, John McCoy
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Patent number: 6300478Abstract: Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.Type: GrantFiled: June 4, 1999Date of Patent: October 9, 2001Assignee: Genetics Institute, Inc.Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
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Patent number: 6284237Abstract: IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.Type: GrantFiled: April 6, 1994Date of Patent: September 4, 2001Inventors: Steven C. Clark, Gordon G. Wong, Paul Schendel, John McCoy
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Patent number: 5942221Abstract: A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises: preparing RNA from a cell that produces CSF; preparing polyadenylated messenger RNA from said RNA; preparing single stranded cDNA from said messenger RNA; converting the single stranded cDNA to double stranded cDNA; inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies; picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool; transfecting the plasmid DNA into suitable host cells for expressing CSF protein; culturing the transfected cells and assaying the supernatant for CSF activity; and selecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e.Type: GrantFiled: June 6, 1995Date of Patent: August 24, 1999Assignee: Novartis CorporationInventors: Steven C. Clark, Randal J. Kaufman, Gordon G. Wong
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Patent number: 5908763Abstract: A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises:preparing RNA from a cell that produces CSF;preparing polyadenylated messenger RNA from said RNA;preparing single stranded cDNA from said messenger RNA;converting the single stranded cDNA to double stranded cDNA;inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies;picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool;transfecting the plasmid DNA into suitable host cells for expressing CSF protein;culturing the transfected cells and assaying the supernatant for CSF activity; andselecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e.Type: GrantFiled: August 8, 1994Date of Patent: June 1, 1999Assignee: Novartis CorporationInventors: Steven C. Clark, Randal J. Kaufman, Gordon G. Wong, Elizabeth A. Wang
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Patent number: 5891429Abstract: A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises:preparing RNA from a cell that produces CSF;preparing polyadenylated messenger RNA from said RNA;preparing single stranded cDNA from said messenger RNA;converting the single stranded cDNA to double stranded cDNA;inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies;picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool;transfecting the plasmid DNA into suitable host cells for expressing CSF protein;culturing the transfected cells and assaying the supernatant for CSF activity; andselecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e.Type: GrantFiled: June 6, 1995Date of Patent: April 6, 1999Assignee: The Novartis CorporationInventors: Steven C. Clark, Randal J. Kaufman, Gordon G. Wong, Elizabeth A. Wang
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Patent number: 5811523Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.Type: GrantFiled: October 22, 1997Date of Patent: September 22, 1998Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
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Patent number: 5734037Abstract: This invention provides a novel human erythropoietic growth factor and processes for producing it by recombinant DNA genetic engineering techniques.Type: GrantFiled: May 9, 1996Date of Patent: March 31, 1998Assignee: Ludwig Institute for Cancer ResearchInventors: Yu-Chung Yang, Agnes Brennan Ciarletta, Susan Teresa Ricciardi, Steven C. Clark, Robert E. Donahue
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Patent number: 5720952Abstract: A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises:preparing RNA from a cell that produces CSF;preparing polyadenylated messenger RNA from the RNA;preparing single stranded cDNA from the messenger RNA;converting the single stranded cDNA to double stranded cDNA;inserting the double stranded cDNA into transformation vectors and transforming bacteria with the vector to form colonies;picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool;transfecting the plasmid DNA into suitable host cells for expressing CSF protein;culturing the transfected cells and assaying the supernatant for CSF activity; andselecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e.Type: GrantFiled: June 6, 1995Date of Patent: February 24, 1998Assignee: Novartis CorporationInventors: Steven C. Clark, Randal J. Kaufman, Gordon C. Wong
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Patent number: 5648072Abstract: Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.Type: GrantFiled: March 13, 1995Date of Patent: July 15, 1997Assignee: Genetics Institute, Inc.Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Michiko Kobayashi, Gordon G. Wong, Rodney Hewick, Stanley F. Wolf
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Patent number: 5648467Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.Type: GrantFiled: March 13, 1995Date of Patent: July 15, 1997Assignee: Genetics Institute, Inc.Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf