Abstract: A method of treating leukopenia, by administering an IL-3 polypeptide, is disclosed.

Abstract: The invention involves DNA molecules which encode a human protein of 144 amino acids, referred to as interleukin-9, or IL-9. The protein is an erythropoietic growth factor. Also disclosed are processes for producing the IL-9 protein via genetic engineering techniques.

Abstract: A novel family of primate CSF-1-like polypeptides is provided via recombinant techniques, including compositions and methods for their production and use.

Abstract: Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.

Abstract: A method for reducing damage or depletion of gut epithelial cells (e.g., as a result of radiation therapy or chemotherapy) by administration of one or more of the following cytokines: interleukin 11 (IL-11), interleukin 6 (IL-6), leukemia inhibitory factor/cholinergic differentiation factor (LIF/CDF), oncostatin M (OSM), or ciliary neurotrophic factor (CNTF).

Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.

Abstract: A method of restoring damaged or depleted cell populations by treating the patient with cytokines, particularly IL-11 and IL-6.

Abstract: Provided by the present invention is a novel cytokine, IL-9, an approximately 144 amino acid protein, characterized by an apparent molecular weight of between 20 to 30 kD and having biological activity in an MO7E cell assay. The cytokine can be used, inter alia, as a mitogen, as an antigen, and to regulate hematopoiesis.

Abstract: A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.

Abstract: An improved method for inducing leukocytosis in a primate is disclosed. The method includes co-administering IL-3 in conjunction with GM-CSF, such that the leukocyte count in the primate is synergistically raised.

Abstract: A novel family of primate IL-3 polypeptides is provided via recombinant techniques.

Abstract: A process for producing a novel protein, CSF-69, is provided. The protein is capable of stimulating proliferation of monocytic lineage types cells in vitro assays. A novel DNA sequence codes on expression for CSF-69.

Abstract: A novel family of primate IL-3-like polypeptides is provided via recombinant techniques.

Abstract: A novel family of primate CSF-1-like polypeptides is provided via recombinant techniques.

Abstract: The mRNA of a distinct human Interleukin-2 concentrated from a plasma source lead to the production and cloning of its cDNA and the elucidation of its sequence and that of the mature protein. Transfer vectors for production of such Interleukin-2 are disclosed along with useful intermediate expression products.

Abstract: A method for identifying and isolating clones containing DNA coding for a desired protein is described. DNA prepared from a cell that expresses the desired protein is inserted into an isolation expression vector having means for replication (as a means of producing DNA) and a suitable promoter for expression of said DNA in a predetermined mammalian host cell as well as means for replication in a bacterial cell. The transient expression vector is then inserted into a bacterial cell for replication of the DNA. Pools of DNA, prepared from a predetermined number of bacterial clones so that the nucleic acids (DNA and RNA) is substantially free of other bacterial contaminants are transfected or microinjected into mammalian host cells and conditioned medium from growing such cells is tested for the presence of the desired protein. Positive pools are selected and the clones used to make the pool are screened to identify and isolate the clone containing the desired DNA.

Abstract: A self-contained window-mounted, heat/cool room air conditioner for automatically maintaining a predetermined indoor room temperature over a wide range of outdoor ambient temperatures. The air conditioner includes a reverse cycle refrigeration system having an inside heat exchange coil and an outside heat exchange coil, the coils being series-connected with an associated refrigerant compressor via a reversing valve wherein the system in addition to functioning in a conventional room air cooling mode can also function as a heat pump to heat room air over a limited range of outdoor ambient temperatures. Low and high wattage resistance heating elements supplement or replace the heating action of the reverse cycle refrigeration system under certain operating conditions. Four thermistor temperature sensors are used to provide precise control of the air conditioner for maximum efficiency.