Abstract: A pre-slit injection site (34) includes a housing (40) with a flow path therethrough. A first end (42) of the housing (40) carries a pre-slit septum (52). One form of a blunt cannula (98), usable with the injection site (34), carries a locking member (100). When the pre-slit injection site (34) slidably receives the blunt cannula (98), the locking member (100) latches to the injection site (34) and creates a mechanically coupled unit. Another form of the cannula (280) includes a tube having a tapered distal end region (298) and having elongate discharge slots (294) for reducing contact surface area and for directing the flow laterally out of the cannula. The cannula may also include a rounded lead post (330), an annular barb (394), and axially oriented grooves (268). A blood sampling system utilizing an in-line pre-slit injetion site (492) and a shielded blunt cannula (512).

Abstract: A pre-slit injection site includes a housing with a flow path therethrough. A first end of the housing carries a pre-slit septum. A second end of the housing carries a coupling component to adapt the site to standard vials. The coupling component, a vial adapter, includes an adapter spike with openings allowing for the drainage of fluid in the vial through the spike and into the injection site. The vial adapter is provided with a skirt housing unit which protects the adapter spike in manufacturing and use. The skirt housing unit also provides features to lockingly engage the adapter with injection site to standard vials, despite dimensional variations in vial closures. Another embodiment of the coupling component is a spike having a barb feature capable of insertion into a standard vial or port and resisting disengagement.A blunt cannula is usable with the injection site combined with the coupling components.

Abstract: A cartridge 444, 644, 744 having a drug or other beneficial agent 608 therein and including an adapter 477 is positioned on a receptacle 442, 642 within a parenteral fluid administration set 420. Also disclosed is an adapter 477' for connecting the receptacle 442, 642 to a chamber 606 having a beneficial agent therein. The cartridge and adapter permit a single opening through the injection site at the receptacle and at the chamber at opposite ends of the flow path means while still permitting simultaneous flow both into and out of the chamber and the receptacle.