Abstract: An ablation electrode assembly is provided with improved irrigation cooling of the assembly and ablation site. The assembly includes a proximal end configured to be coupled to a catheter shaft and a distal end configured to deliver ablation energy to tissue. The assembly further includes a fluid manifold extending from the proximal end to the distal end and configured to fluidly communicate with a fluid lumen in the catheter shaft. The fluid manifold defines an axial passageway centered about a longitudinal axis extending in the longitudinal direction of the assembly. The axial passageway has a distal end terminating prior to the distal end of the electrode assembly. The assembly further includes means for creating turbulence in fluid exiting the first axial passageway.

Abstract: An earth-boring tool includes a body comprising a pocket in a leading end thereof for accepting at least a portion of a bearing element assembly. A bearing element assembly may be disposed within the pocket, and the bearing element assembly may include a retaining element at least partially disposed in a groove in a sidewall of the pocket and a bearing element. The bearing element may include a distal end having a bearing surface, a proximal end, and a side surface between the distal end and the proximal end, the side surface comprising a feature configured to abut the retaining element, wherein mechanical interference between the feature and the retaining element axially retains the bearing element within the pocket. Methods include disengaging a mechanical retention device retaining a bearing element within a pocket in a body of the earth-boring tool, and removing the bearing element from the pocket.

Abstract: A method includes a wireless mobile communication device discovering a proximate wireless audio device, receiving a device name from the wireless audio device, and providing the device name to a content server. The method further includes the content server analyzing the device name to identify a location or activity, selecting content relevant to the identified location or activity, and providing the selected content to the wireless mobile communication device. Optionally, the location or activity may be a kitchen, garage or other room of a residence or a conference room or break room of a business. The selected content is preferably relevant to the location or activity, such as an advertisement for tools or lawn equipment responsive to the identified location being the garage.

Abstract: An apparatus and process is disclosed for the cooling of a reactor effluent gas stream. The apparatus includes a contact cooling system with a discharge drum providing a second wash zone. Each wash zone has a packed bed, or other type of mechanical system for contacting the gas stream with the cooling liquid. The liquid in the first stage will remove heavy components, allowing for a cleaner second stage that can be reduced in size.

Abstract: An analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.

Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

Abstract: A computer program product includes program instructions executable by a processor, such as a supervisory controller within a computer to perform a method. The method includes identifying PCIe devices installed within the computer and identifying one or more configurable link width for each of the identified PCIe devices, wherein each PCIe device is determined to be installed in a particular PCIe slot. The method further includes granting a higher priority to a first one of the PCIe devices than to a second one of the PCIe devices, and controlling the allocation of a fixed number of serial communication lanes from a processor to the plurality of PCIe devices, wherein the first PCIe device is allocated the maximum configurable link width identified for the first PCIe device and the second PCIe device is allocated a link width less than the maximum configurable link width identified for the second PCIe device.

Abstract: A method includes a supervisory controller within a computer identifying a plurality of PCIe devices installed within the computer and identifying one or more configurable link width for each of the identified PCIe devices, wherein each of the identified PCIe devices is determined to be installed in a particular PCIe slot. The method further includes the supervisory controller granting a higher priority to a first one of the PCIe devices than to a second one of the PCIe devices, and the supervisory controller controlling the allocation of a fixed number of serial communication lanes from a processor to the plurality of PCIe devices, wherein the first PCIe device is allocated the maximum configurable link width identified for the first PCIe device and the second PCIe device is allocated a link width less than the maximum configurable link width identified for the second PCIe device.

Abstract: A surgical generator and related method for mitigating overcurrent conditions are provided. The surgical generator includes a power supply, a radio frequency output stage, an overcurrent detection circuit in operative communication with an interrupt circuit, and a processor. The power supply generates a power signal and supplies the power signal to the radio frequency output stage. The radio frequency output stage generates a radio frequency signal from the power signal. The overcurrent detection circuit detects an overcurrent of the power signal and/or an overcurrent of the radio frequency signal. The interrupt circuit provides an interrupt signal in response to a detected overcurrent. The processor receives the interrupt signal and supplies a pulse-width modulation signal to the power supply and incrementally decreases the duty cycle of the pulse-width modulation signal in response to the interrupt signal. The radio frequency output stage may be disabled in response to the detected overcurrent.

Abstract: Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with an absorbent paper or membrane, optionally facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples on the absorbent paper or membrane to evaluate breast disease, including cancer. The biological sample may include fluid containing one or more of cells or cellular components, proteins, glycoproteins, peptides, nucleotides or other desired constituents comprising a breast disease marker. Absorbent paper or membrane, and methods relating to the paper or membrane, and a breast pump device are also provided.

Abstract: A memory space of a module connected to a memory controller via a memory interface may be used as a command buffer. Commands received by the module via the command buffer are executed by the module. The memory controller may write to the command buffer out-of-order. The memory controller may delay or eliminate writes to the command buffer. Tags associated with commands are used to specify the order commands are executed. A status buffer in the memory space of the module is used to communicate whether commands have been received or executed. Information received via the status buffer can be used as a basis for a determination to re-send commands to the command buffer.

Abstract: A system and method for capturing, processing, and presenting information includes having customers provide initial information and additional information for use in creating a product for presenting all or a portion of the provided information. A feature of the system and method includes mining the customer-provided information to include other relevant information, not directly supplied by the customer, in the product. A further feature of the system and method includes using the customer-provided information to generate targeted advertising in the form of targeted coupons or other offers for the customer. A further feature of the system and method includes inviting the customers to create an online registry to provide information for use in creating the product.

Abstract: A formation-engaging assembly includes a formation-engaging structure holder with a side surface between a proximal end and a distal end, a receptacle in the distal end, and a lateral protrusion extending from a portion of the side surface of the formation-engaging structure holder adjacent the distal end. A formation-engaging structure may include a formation-engaging surface at a distal end, a proximal end and a sidewall therebetween. The proximal end and at least a portion of the sidewall of the formation-engaging structure may be received within the receptacle of the formation-engaging structure holder. Earth-boring tools may include such formation-engaging assemblies.

Abstract: An implantable drug delivery system including: a biocompatible or bio-inert housing containing a drug infusion pump, a drug chamber from which a liquid drug is dispensed when the pump applies a force to the drug chamber, and an internal controller actuating the pump; a delivery catheter extending from the housing to one or more drug delivery treatment sites in a target tissue, wherein the catheter includes a lumen having an inlet to receive a drug pumped from the drug chamber and an outlet are positioned at the target tissue, wherein the drug flows through the outlet to the target tissue, and wherein the internal controller stores and executes an automatic periodic flow regimen which commands the pump and drug chamber to periodically dispense an intermittent bolus or pulse of the liquid drug, wherein the periodic flow regimen provides a prophylactic treatment for granuloma.

Abstract: A method and system of verifying and authenticating personal history data of a subject comprising requesting the personal history data of the subject from a data base provider, searching the data base for the personal history data of the subject, transmitting the requested personal history data to the requester, reviewing the personal history data by the subject and verifying the accuracy of the personal history data by the subject and authenticating the verified personal history data by the subject.

Abstract: In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.

Abstract: A laparoscopic scissor instrument can include a scissor assembly pivotally coupled to an elongate shaft. The scissor assembly can be formed of scissor blades having pivot posts thereon. The pivot posts can engage apertures on the elongate shaft, thus eliminating the need for a through-pinned pivot connection of the scissor blades. The scissor blades can also include actuation posts thereon. An actuation mechanism can include a slot to engage the actuation posts and open or close the blades of the scissor assembly. The scissor assemblies described herein can have a relatively low operational height such that they do not extend beyond a diameter of the elongate shaft during opening and closing of the scissor assembly.

Abstract: A physiological characteristic sensor, a method for forming a physiological characteristic sensor, and a method for forming a platinum deposit having a rough surface are presented here. The method for forming a physiological characteristic sensor includes immersing a sensor electrode in a platinum electrolytic bath. Further, the method includes performing an electrodeposition process by sequentially applying a pulsed signal to the sensor electrode and applying a non-pulsed continuous signal to the sensor electrode to form a platinum deposit on the sensor electrode.

Abstract: A door assembly includes a structure including an exterior panel defining an opening, and a grab bar. The grab bar is moveable relative to the exterior panel. A first linkage system and a second linkage system interconnect the grab bar and the structure. A drive assembly is coupled to the first linkage system and the second linkage system to move the grab bar between an extended position and a retracted position. The drive assembly includes a Shape Memory Alloy (SMA) actuator that contracts in response to a control signal, to move the grab bar. A seal may be provided to seal between the grab bar and the structure. A heating element may provide a thermal load to heat the grab bar, a seal surrounding the grab bar, or both.

Abstract: The present disclosure provides meroduplex (nicked or gapped) ribonucleic acid molecules (mdRNA) that decreases or silences target gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a target gene RNA. In addition, the meroduplex may have one or more modifications or substitutions, such as nucleotide base, sugar, terminal cap structure, internucleotide linkage, or any combination of such modifications. Also provided are methods of decreasing expression of a target gene in a cell or in a subject to treat a disease related to altered expression of a target gene.