Abstract: Absorbent cores for use in absorbent articles are presented. The absorbent cores include a low-density zone that is surrounded by zones having a higher density than that of the low-density zone. The low-density zone aids in fluid absorption, distribution and storage.

Abstract: A diagnostic sheet for use in conjunction with a disposable absorbent garment is disclosed. The diagnostic sheet may be operable to wick fluid vertically, and includes one or more diagnostic elements and a radio frequency identification device (RFID). The one or more diagnostic elements may be integrated with the diagnostic sheet and positioned at a first region of the diagnostic sheet, and the RFID may be integrated with the diagnostic sheet and positioned proximate the first region. In the presence of the fluid, each of the one or more diagnostic elements may be configured to indicate a result of a particular diagnostic test. In the presence of the fluid, the RFID may be configured to provide an indication that the fluid wicked by the diagnostic sheet has reached the one or more diagnostic elements.

Abstract: A diagnostic sheet for use in conjunction with a disposable absorbent garment is disclosed. The diagnostic sheet may be operable to wick fluid vertically, and includes one or more diagnostic elements and a radio frequency identification device (RFID). The one or more diagnostic elements may be integrated with the diagnostic sheet and positioned at a first region of the diagnostic sheet, and the RFID may be integrated with the diagnostic sheet and positioned proximate the first region. In the presence of the fluid, each of the one or more diagnostic elements may be configured to indicate a result of a particular diagnostic test. In the presence of the fluid, the RFID may be configured to provide an indication that the fluid wicked by the diagnostic sheet has reached the one or more diagnostic elements.

Abstract: Absorbent cores for use in absorbent articles are presented. The absorbent cores include a low-density zone that is surrounded by zones having a higher density than that of the low-density zone. The low-density zone aids in fluid absorption, distribution and storage.

Abstract: A disposable absorbent article, such as a diaper having a pair of waist sections, a crotch section disposed between the waist sections, a liquid pervious topsheet, a liquid impervious backsheet, an absorbent core disposed between the topsheet and the backsheet, a leg cuff attached to the topsheet at least in part parallel to a longitudinal axis at a first attachment region, a leg gather section which runs along an outer edge region of the crotch section, wherein the leg gather section comprises an outer boundary and an inner boundary, wherein the outer boundary is defined by the edge of the crotch region and the inner boundary is defined by the first leg cuff attachment region; and wherein the leg gather region and leg cuff are attached together at least in part at a second attachment region.

Abstract: Absorbent articles and methods for making absorbent articles incorporate unbleached fibers in an absorbing core. Example embodiments provide unbleached fibers which are totally chlorine free. Such unbleached fibers provide features and advantages not present or recognized over prior articles. According to one embodiment, a disposable absorbent article having a front waist region, a back waist region, and a crotch region located between the front and back waist regions, is provided. The disposable absorbent article includes a liquid pervious topsheet and a liquid impervious backsheet. Additionally, the disposable absorbent article includes an absorbent core disposed between at least a portion of the topsheet and bottom sheet. This absorbent core comprises a superabsorbent material and pulp material where at least a portion of the pulp material includes unbleached fibers having constituents which alter the performance properties of the absorbent core.

Abstract: Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.

Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viablility of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: 1

Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.

Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.