Patents by Inventor Steven D. Linton

Steven D. Linton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Patent number: 6444663
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: September 3, 2002
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Steven D. Linton
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
    Publication number: 20020042376
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: January 16, 2001
    Publication date: April 11, 2002
    Inventors: Donald S. Karanewsky, Robert J. Ternansky, Steven D. Linton, Thang Dinh
  • Novel tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Publication number: 20020016321
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Application
    Filed: December 5, 2000
    Publication date: February 7, 2002
    Inventors: Donald S. Karanewsky, Steven D. Linton
  • Inhibition of apoptosis using interleukin-1B-converting enzyme (ICE)/CED-3 family inhibitors
    Publication number: 20010044415
    Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukinf-1&bgr;-converting enzyme ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: March 12, 2001
    Publication date: November 22, 2001
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewski, Steven D. Linton, Xu Bai
  • Inhibition of apoptosis using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors
    Patent number: 6200969
    Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: March 13, 2001
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewski, Steven D. Linton, Xu Bai
  • Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Patent number: 6187771
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: February 13, 2001
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Steven D. Linton
  • Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Patent number: 5968927
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: October 19, 1999
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Steven D. Linton