Patents by Inventor Steven David Knight

Steven David Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100234386
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: September 16, 2010
    Inventors: Amita Chaudhari, Dashyant Dhanak, Carla Ann Donatelli, Thomas H. Faitg, Yanhong Feng, Steven David Knight, Cynthia A. Parrish, Jeffrey M. Ralph, Martha A. Sarpong, Domingos J. Silva
  • Publication number: 20100216801
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: August 26, 2010
    Inventors: Dashyant Dhanak, Steven David Knight
  • Publication number: 20100179144
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.
    Type: Application
    Filed: June 12, 2008
    Publication date: July 15, 2010
    Inventors: Nicholas D. Adams, Joelle Lorraine Burgess, Michael Gerard Darcy, Steven David Knight, Kenneth Allen Newlander, Lance H. Ridgers, Stanley J. Schmidt
  • Publication number: 20100152112
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
    Type: Application
    Filed: May 16, 2008
    Publication date: June 17, 2010
    Inventors: Nicholas D. Adams, Joelle Lorraine Burgess, Michael Gerard Darcy, Carla A. Donatelli, Steven David Knight
  • Publication number: 20100105767
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: October 20, 2009
    Publication date: April 29, 2010
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgan, JR., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • Publication number: 20090306074
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
    Type: Application
    Filed: April 11, 2007
    Publication date: December 10, 2009
    Inventors: Michael Gerard Darcy, Steven David Knight, Nicholas D. Adams, Stanley J. Schmidt
  • Patent number: 7629477
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: December 8, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, Jr., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • Publication number: 20090215818
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiozolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiozolidinedione derivatives.
    Type: Application
    Filed: July 24, 2007
    Publication date: August 27, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: Nicholas D. Adams, Dashyant Dhanak, Steven David Knight, Lee Schaller, Jun Tang
  • Publication number: 20090203732
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: August 13, 2009
    Inventors: Dashyant Dhanak, Steven David Knight
  • Publication number: 20090170882
    Abstract: Compounds, compositions and methods relating to kinesin inhibition are described herein.
    Type: Application
    Filed: June 30, 2005
    Publication date: July 2, 2009
    Inventors: Dashyant Dhanak, Steven David Knight, Michael Lee Moore, Kenneth Alan Newlander
  • Publication number: 20090170848
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Dahsyant Dhanak, Steven David Knight
  • Patent number: 7528137
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: May 5, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Bainian Feng, Gustave Bergnes, David J. Morgans, Jr., Dashyant Dhanak, Steven David Knight, Michael Gerard Darcy
  • Publication number: 20090082349
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: March 26, 2009
    Inventors: Dashyant Dhanak, Steven David Knight
  • Publication number: 20090048252
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: February 19, 2009
    Inventors: Dashyant Dhanak, Steven David Knight
  • Patent number: 7491746
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: February 17, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, Jr., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • Patent number: 7482343
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: January 27, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Han-Jie Zhou, David J. Morgans, Jr., Gustave Bergnes, Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Nicholas D. Adams
  • Publication number: 20090023742
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: January 22, 2009
    Inventors: Dashyant Dhanak, Steven David Knight
  • Publication number: 20090018131
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.
    Type: Application
    Filed: June 12, 2008
    Publication date: January 15, 2009
    Inventors: Nicholas D. ADAMS, Joelle Lorraine BURGESS, Michael Gerard DARCY, Steven David KNIGHT, Kenneth Allen NEWLANDER, Lance H. RIDGERS, Stanley J. SCHMIDT
  • Patent number: 7476743
    Abstract: 1,2,4-Tiazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: January 13, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Xiangping Qian, Gustave Bergnes, David J. Morgans, Jr., Steven David Knight, Dashyant Dhanak
  • Publication number: 20090005580
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: June 19, 2008
    Publication date: January 1, 2009
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, JR., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook