Abstract: A method for predicting distortion of a part during sintering in an additive process includes receiving a computerized representation of a complex geometric part, discretizing the computerized representation of the complex geometric part into a plurality of elements, processing the plurality of elements of the computerized representation of the complex geometric part with a machine-learning model configured to predict a distorted geometry of the complex geometric part in response to a sintering process, wherein the machine-learning model is trained to predict distortion of a set of primitive geometric coupons represented by image data fed into the machine-learning model during training, the set of primitive geometric coupons having fewer geometries than the complex geometric part, the complex geometric part comprises a plurality of geometries corresponding to geometries associated with the set of primitive geometric coupons, and generating a computerized representation of the predicted distorted geometry of t

Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: A mechanical swing brake variable control system for an earth-moving machine including an upper revolving car body with swing components mounted on the upper revolving car body, a lower traveling car body with traction components mounted on the lower traveling car body, and a mechanical service brake interconnected with the upper and lower car bodies, controls relative rotation between the upper and lower car bodies. A pressure control device controls a variable pressure applied to the mechanical service brake to vary an amount of swing drive holding torque. An electronic controller monitors and processes signals received from sensors associated with the swing components and machine operator commands, and variably controls the amount of holding torque exerted on the upper revolving car body using the mechanical service brake as a function of one or more of machine roll angle, operational configuration of the swing components, inertial mass of the swing components, and machine operator commands.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A device, a method, and a non-transitory storage medium are described in which an antenna assembly detection service is provided. A device may include an oscillator circuit whose frequency of operation is determined by a resonant frequency of a tank circuit and reactance of a load associated with the antenna terminal configured to receive an external antenna. A controller may be configured to measure an output signal of the oscillator circuit when the oscillator circuit is connected to the antenna terminal, and determine whether or not the external antenna is connected to the antenna terminal based on the measurement and comparison data.

Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract: A handle for a hinged door comprises a first portion having a flat affixing surface. A second portion is spaced apart from and parallel to the first portion. A third portion connected to lateral edges of the first and second portion form a U shape having an opening away from the third portion.

Abstract: A method for inspecting a part in a manufacturing environment, the method including: acquiring at least one image of the part; optionally enhancing the at least one image; automatically analyzing the enhanced image to determine if the part has a potential defect; if it is determined that there is a potential defect: displaying the at least one image to an operator; and receiving operator input of a part status, wherein the part status may be defect or no defect; and storing the part status in association with the at least one image. The automatic analysis may include a confidence level and only images having a confidence level that does not meet a threshold will be displayed to an operator.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: An automated tarping device and system is provided, wherein the at least two swing arm devices of the tarping system are configured to be enclosed within the side walls and frame of the trailer, when the automated tarping system is in a fully closed position so as to cover the opening of the trailer with the tarp assembly. When the system is in a closed position, the swing arm devices themselves are covered by the tarp. The system also includes a tarp assembly comprising a flexible tarp and first and second resilient actuating ribs. The attaching member of each swing arm device releasably couples to an actuating rib, and the tarp and the first and second actuating ribs of the tarp assembly are transversely disposed across, so as to cover, the opening of the trailer when the arm devices are in the closed position.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A method of bonding composite structures includes positioning a second structure at a bonding site on a first structure and coupling a first vacuum bag to the first structure such that the first vacuum bag covers the bonding site. The method also includes applying a vacuum to the first vacuum bag to induce a first mechanical force to the second structure via the first vacuum bag. A second vacuum bag is coupled to the first structure such that second vacuum bag covers the second structure and at least a portion of the first vacuum bag. The method further includes applying a vacuum to the second vacuum bag to induce a second mechanical force to the second structure via the second vacuum bag.