Abstract: A parking brake system is disclosed and includes one or more pressure transducers that monitor the fluid pressure of the parking brake system and a brake selection device configured to indicate the parking brake system is either in an engaged state or a disengaged state. The parking brake system includes one or more processors and a memory coupled to the one or more processors. The memory stores data comprising a database and program code that, when executed by the one or more processors, causes the parking brake system to determine the fluid pressure of the parking brake system is less than a threshold pressure. In response to determining the fluid pressure of the parking brake system is less than the threshold pressure, the parking brake system instructs the brake selection device to indicate the parking brake system is in the disengaged state.

Abstract: A brake system for a vehicle is disclosed and includes an energy storage device configured to store and discharge energy, a plurality of wheels, one or more processors operatively coupled to the energy storage device, and a memory coupled to the one or more processors. The memory stores data comprising a database and program code that, when executed by the one or more processors, causes the brake system to determine the brake system is operating in a backup mode of operation. In response to determining the brake system is operating in the backup mode of operation, the brake system calculates a dynamic slip of the plurality of wheels. The brake system is caused to determine a slip error by comparing the dynamic slip with a target slip value of the plurality of wheels. The brake system is also caused to calculate an antiskid command based on the slip error.

Abstract: A brake system for a vehicle is disclosed and includes an energy storage device configured to store and discharge energy, a plurality of wheels having an observer wheel, one or more processors operatively coupled to the energy storage device, and a memory coupled to the one or more processors. The memory stores data comprising a database and program code that, when executed by the one or more processors, causes the brake system to determine the brake system is operating in a backup mode of operation. In response to determining the brake system is operating in the backup mode of operation, the brake system is caused to apply a first brake pressure command to the observer wheel. In response to determining the observer wheel is starting the skid condition, the brake system is caused to determine a second brake pressure command based on a target slip value.

Abstract: A brake system is disclosed. The brake system includes a brake stack having a stack closure pressure, a force member positioned within a cylinder, a valve configured to control fluid pressure of the brake system, and one or more pressure transducers that generate a proportional electrical signal representative of the fluid pressure within the cylinder. The brake system also includes one or more processors in electronic communication with the valve, the one or more pressure transducers, and a memory coupled to the one or more processors. The memory stores data comprising a database and program code that, when executed by the one or more processors, causes the brake system to determine the stack closure pressure of the brake stack.

Abstract: A brake system is disclosed. The brake system includes a brake stack having a stack closure pressure, a force member positioned within a cylinder, a valve configured to control the fluid pressure of the brake system, and one or more pressure transducers that generate a proportional electrical signal representative of fluid pressure within the cylinder. The brake system also includes one or more processors in electronic communication with the valve, the one or more pressure transducers, and a memory coupled to the one or more processors. The memory stores data comprising a database and program code that, when executed by the one or more processors, causes the brake system to determine the stack closure pressure of the brake stack.

Abstract: The present disclosure features signal-regulatory protein ? (SIRP-?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein ? (SIRP-?) D1 variant and (ii) an antibody.

Abstract: The present disclosure features signal-regulatory protein ? (SIRP?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein ? (SIRP-?) D1 variant and (ii) an antibody.

Abstract: The present disclosure features signal-regulatory protein a (SIRP?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein a (SIRP-?) D1 variant and (ii) an antibody.

Abstract: The present disclosure features signal-regulatory protein ? (SIRP-?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein ? (SIRP-?) D1 variant and (ii) an antibody.

Abstract: During a feature-selection technique, an electronic device calculates combinations of features and noise vectors, where a given combination corresponds to a given feature and a given noise vector. Then, the electronic device determines statistical associations between information specifying types of events and the combinations, where a given statistical association corresponds to the types of events and a given combination. Moreover, the electronic device identifies a noise threshold associated with the combinations. Next, for a group of combinations having statistical associations equal to or greater than the noise threshold, the electronic device selects a subset of the features based at least in part on a first aggregate property of the group of combinations, where the first aggregate property comprises numbers of occurrences of the features in the group of combinations.

Abstract: Provided herein, inter alia, are isolated antibodies that bind an extracellular domain of a human SIRP-? v1 polypeptide (e.g., the D1 domain), an extracellular domain of a human SIRP-? v2 polypeptide, or both. In some embodiments, the antibodies also bind an extracellular domain of a monkey SIRP-? polypeptide, an extracellular domain of a mouse SIRP-? polypeptide, an extracellular domain of a human SIRP-? polypeptide, and/or an extracellular domain of a human SIRP-? polypeptide. In some embodiments, the antibodies block or do not binding between an extracellular domain of a human SIRP-? polypeptide and an IgSF domain of a human CD47 polypeptide, while in some embodiments, the antibodies reduce the affinity of a human SIRP-? polypeptide for binding an IgSF domain of a human CD47 polypeptide. Further provided herein are methods, polynucleotides, vectors, and host cells related thereto.

Abstract: An apparatus determines patterns of occurrence of compound variables based on a set of mathematical interactions and patterns of occurrence of a set of electrical signals. Then, the apparatus calculates statistical relationships corresponding to a pattern of occurrence of neural activity of one or more organisms and the patterns of occurrence of the compound variables. Moreover, the apparatus determines numbers of occurrences of electrical signals that were used to determine compound variables in at least a statistically significant subset of the compound variables, and determines numbers of different mathematical interactions that were used to determine the compound variables in the subset for the electrical signals that are associated with the corresponding numbers of occurrences. Next, the apparatus identifies one or more of the electrical signals as one or more association variables based on the numbers of occurrences and/or the numbers of different mathematical interactions.

Abstract: An apparatus determines patterns of occurrence of compound variables based on a set of mathematical interactions and patterns of occurrence of a set of biological variables. Then, the apparatus calculates statistical relationships corresponding to a pattern of occurrence of a trait in a group of life forms and the patterns of occurrence of the compound variables. Moreover, the apparatus determines numbers of occurrences of biological variables that were used to determine compound variables in at least a statistically significant subset of the compound variables, and determines numbers of different mathematical interactions that were used to determine the compound variables in the subset of the compound variables for the biological variables that are associated with the corresponding numbers of occurrences. Next, the apparatus identifies one or more of the biological variables as one or more association variables based on the numbers of occurrences and the numbers of different mathematical interactions.

Abstract: The present disclosure features signal-regulatory protein ? (SIRP-?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein ? (SIRP-?) D1 variant and (ii) an antibody.

Abstract: An apparatus, and related method, for identifying one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module stored in the memory configured to be executed by the processor. The program module includes instructions for selecting a subset of temporal onsets in a set of temporal onsets, instructions for determining a statistical relationship between the subset and a pattern of occurrence of a variable, and instructions for identifying the variable as an association variable in accordance with the statistical relationship. The subset includes one or more first temporal onsets corresponding to one or more instances of an event, and the set of temporal onsets includes the subset of temporal onsets and one or more second temporal onsets corresponding to one or more instances of a reoccurrence event.

Abstract: An apparatus, and related method, for providing information based on variables associated with a type of headache is described. The apparatus may include at least one processor, at least one memory, and at least one program module. The program module may be stored in the memory and may be configured or configurable to be executed by the processor. The program module may include instructions for receiving a list of variables. Note that these variables may be triggers that at least in part induce a headache associated with the type of headache in at least one individual if at least the one individual is exposed to one or more of the variables. The program module may include instructions for determining that at least the one individual is at risk of experiencing a headache associated with the type of headache during a first time interval. This determination may be based on the variables.

Abstract: A computer implemented method, apparatus, and computer usable program code to receive data from a source at a plurality of gateways for distribution using a selected priority. The data is transmitted from the plurality of gateways to a plurality of receivers using the selected priority. Every gateway in the plurality of gateways has an adaptive bandwidth control process and a respective set of parameters for controlling the adaptive bandwidth control process for sending the data at the selected priority. Transmission of the data from each gateway for the selected priority has a different impact on other traffic at different gateways in the plurality gateways for the selected priority when different values are set for the set of parameters for the different gateways.

Abstract: An apparatus, and related method, for identifying one or more association variables that are associated with a trait are described. During the method, the apparatus may calculate statistical relationships corresponding to a pattern of occurrence of the trait in a group of life forms and patterns of occurrence of compound variables in a set of biological variables of the group of life forms. Then, the apparatus may determine a ranking of a number of occurrences of biological variables in at least a subset of the compound variables that have statistical relationships greater than a statistical confidence value. Next, the apparatus may identify one or more of the biological variables in the set of biological variables as the one or more association variables based on the ranking.

Abstract: After receiving information specifying an occurrence of a temporal onset of an episodic manifestation of a chronic disease in an individual during a time interval, a question and associated categorical answers about exposure of the individual to a potential trigger of the episodic manifestation are provided. Note that the categorical answers include time intervals, and both the time interval and the time intervals correspond to a first temporal sampling rate. If an answer to the question specifies one of the time intervals that is the same as the time interval, another question and additional associated categorical answers about the exposure of the individual to the potential trigger of the episodic manifestation are provided.

Abstract: A computer implemented method, apparatus, and computer usable program code to monitor transmission of data to target. A determination is made as to whether the transmission of the data exceeds a threshold. The bandwidth used to transmit the data to the target is controlled using an adaptive bandwidth control process if the transmission of the data exceeds the threshold, wherein a minimum amount of bandwidth is guaranteed for the transmission of the data.