Abstract: An oxygen box is secured in an oxygen box hole through a panel of an aircraft cabin by fasteners that are positioned in an interior volume of the oxygen box and are inserted through holes in a back wall of the oxygen box that are aligned with fastener openings in an exterior bracket positioned behind the panel and behind the oxygen box opening where the fasteners are received by the fastener openings in the exterior bracket and the fasteners removably attach the oxygen box to the exterior bracket.

Abstract: The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.

Abstract: A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

Abstract: A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.

Abstract: This invention relates to nicotine microparticles formulations made with the help of a diketopiperazine compound, in particular fumaryl diketopiperazine (FDKP). The invention relates to the various types of microparticles that can be made, in particular nicotine-coated and nicotine-loaded microparticles. The invention further relates to the various methods that can be used in making the microparticles. One particular method involves making FDKP microparticles which are further surface-coated with nicotine. Another particular method involves mixing nicotine with FDKP2? and/or FDKP and then forming microparticles which contain nicotine throughout their volume. The invention also relates to the use of this microparticles in tobacco related therapies, such as tobacco replacement or tobacco withdrawal.

Abstract: Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.

Abstract: A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.

Abstract: The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.

Abstract: A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.

Abstract: An oxygen box is secured in an oxygen box hole through a panel of an aircraft cabin by fasteners that are positioned in an interior volume of the oxygen box and are inserted through holes in a back wall of the oxygen box that are aligned with fastener openings in an exterior bracket positioned behind the panel and behind the oxygen box opening where the fasteners are received by the fastener openings in the exterior bracket and the fasteners removably attach the oxygen box to the exterior bracket.

Abstract: A method of reducing nicotine cravings is described. The method includes inhalation of a dry powder formulation containing a dose of nicotine by a subject seeking nicotine cravings reduction. The formulation includes amounts and concentrations of nicotine that are significantly lower than cigarettes or nicotine replacement therapies.

Abstract: The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.

Abstract: The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.

Abstract: This invention relates to nicotine microparticles formulations made with the help of a diketopiperazine compound, in particular fumaryl diketopiperazine (FDKP). The invention relates to the various types of microparticles that can be made, in particular nicotine-coated and nicotine-loaded microparticles. The invention further relates to the various methods that can be used in making the microparticles. One particular method involves making FDKP microparticles which are further surface-coated with nicotine. Another particular method involves mixing nicotine with FDKP2? and/or FDKP and then forming microparticles which contain nicotine throughout their volume. The invention also relates to the use of this microparticles in tobacco related therapies, such as tobacco replacement or tobacco withdrawal.

Abstract: A method, system, computer program product, and related business methods for phased rollout of an upgraded version of a web-based business information system are described. URLs associated with client requests remain the same even where the target subscriber accounts have been upgraded. Client requests for both upgraded and non-upgraded accounts are received by a common set of web servers. Client requests representing external entry points are trapped, and the receiving web server accesses a login router database to determine whether the target subscriber account is upgraded or non-upgraded, and then transfers the request to an appropriately-versioned application server. Application server sets are mapped to database sets according to system version, allowing the upgraded system database schema to be substantially different than the non-upgraded database schema. An early adopter program business method leveraging the abilities of such web-based business information system is also described.

Abstract: Separating apparatus, for separating a substance from a liquid on which the substance can float, comprises: a separation chamber; an inlet adapted to convey a supply comprising the substance and the liquid into the separation chamber; and an outlet adapted to convey liquid collected in the separation chamber out of the separation chamber. The inlet is arranged such that, in use, the supply emerging from the inlet into the chamber is directed upwardly into the chamber, and the apparatus further comprises venting means arranged to convey gas out of the chamber. The apparatus may further comprise a floating pick up connected to a pump for pumping the supply to the separation chamber. In certain examples a non-floating pick up is used, comprising an elongate hollow body with a pick up inlet mouth in the form of a vertical slot extending along a length of the body.

Abstract: A cue sheet generation system is used to compose a cue sheet for submission to PRS from an input EDL. The system parses the EDL to extract data relating to use of musical works associated with a PRS. The system employs both local and remote databases to retrieve information relating to the extracted musical work data. The information is then used to construct a cue sheet in a form appropriate for submission to a PRS.

Abstract: Isolated DNA encoding each of human calcium channel ?1-, ?2-, ?- and ?-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Abstract: Separating apparatus, for separating a substance from a liquid on which the substance can float, comprises: a separation chamber; an inlet adapted to convey a supply comprising the substance and the liquid into the separation chamber; and an outlet adapted to convey liquid collected in the separation chamber out of the separation chamber. The inlet is arranged such that, in use, the supply emerging from the inlet into the chamber is directed upwardly into the chamber, and the apparatus further comprises venting means arranged to convey gas out of the chamber. The apparatus may further comprise a floating pick up connected to a pump for pumping the supply to the separation chamber. In certain examples a non-floating pick up is used, comprising an elongate hollow body with a pick up inlet mouth in the form of a vertical slot extending along a length of the body.

Abstract: A network processing device provides a novel architecture for conducting firewall and other network interface management operations. In another aspect of the invention, a Unified Policy Management (UPM) architecture uses a same memory and processing structure to integrate firewall policy management with routing and switching decisions. In another embodiment, a Reconfigurable Semantic Processor (RSP) uses a parser to identify different syntactic elements that are then used by one or more Semantic Processing Units (SPUs) to carry out different firewall, network interface, routing, switching, and other packet processing operations.