Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A live event polling system is disclosed that provides passive engagement tools and micro-polling services during live events so that live event hosts and developers of virtual spaces can engage their audiences and collect valuable input and data more effectively and promote audience participation for sentiment sharing and data collection in ways that overcome conventional barriers, such as time and user participation, which exist to gaining verbal input during such live events.

Abstract: The present disclosure provides a method for hemodialysis of blood, comprising providing a hemodialysis catheter having a low recirculation distal tip, a first and a second extension tubes that are configured to be connected to a dialysis machine, providing a hemodialysis machine with an arterial patient connector and a venous patient connector; conducting hemodialysis with the first extension tube connects to the arterial patient connector of the dialysis machine, and the second extension tube connects to the venous patient connector of the dialysis machine; and periodically reversing the first and second extension tubes connections to the arterial and venous patient connectors of the dialysis machine in a subsequent hemodialysis. The present disclosure also provides a hemodialysis catheter, comprising a switchable connection indicator indicating connection to arterial or venous flow path. The switchable connection indicator can be integrated with a clamp.

Abstract: The present invention provides a method of lowering blood pressure in a subject, comprising genetically modifying a myosin phosphatase target subunit (Mypt1) gene in a vascular smooth muscle cell of the subject, whereby the genetic modification of Mypt1 results in a deletion or inactivation of exon 24. The invention further provides vectors, host cells, and compositions useful for carrying out the methods of the invention.

Abstract: Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

Abstract: An oral care composition comprising zinc phosphate and stannous fluoride.

Abstract: The present invention provides compounds and methods targeting human tau, particularly human tau phosphorylated at threonine 217 and isoforms of tau expressed only in the CNS, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications useful in the field of neurodegenerative diseases such as AD, PSP and FTD.

Abstract: A secure self-mailing financial instrument for payments/fund transfers and methods for processing are disclosed which provide a packaging mailer with a detachable securely printed financial instrument attached for the purpose of facilitating secure and convenient delivery of funds for fund transfers, payments, or purchases, including methods for assembling, opening, and preparing for shipment and for processing locally at one of a point of sale location and a website that provides a service to remotely process preparation, shipment, and delivery of the financial instrument as a mailer, as well as for remote printing, processing, folding and sealing, and tracking.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

Abstract: Flavour components for use in oral care compositions containing a metal salt, compositions comprising the flavour components, and methods of making and using the same. The flavour components comprise a taste-masking agent comprising cinnamic aldehyde, eugenol and eucalyptol and one or more flavouring agents selected from L-menthol, N-ethyl-p-enthane-3-carboxamide, anethole, peppermint oil, spearmint oil and corn mint oil. In particular the metal salt is zinc citrate.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: A system for the transmission of data to a plurality of user devices from one or more sources. User devices located at a receiving location having a wireless range area and provided with capability of receiving data transmitted wirelessly within the area and processing the same to allow video and/or audio generated from the received data by the user device which typically includes a user interface to allow user interaction via the device to select, from one or more available programs or program channels, a program to be viewed and/or listed to via the device. The data for the selected program is obtained from the wirelessly transmitted data so as to be available to the user device. Typically a server and processing means for the data are located at a transmitting head end of a satellite transmission system and at the receiving location there is provided at least one set of wireless data transmission apparatus.

Abstract: The present disclosure provides a method for hemodialysis of blood, comprising providing a hemodialysis catheter having a low recirculation distal tip, a first and a second extension tubes that are configured to be connected to a dialysis machine, providing a hemodialysis machine with an arterial patient connector and a venous patient connector; conducting hemodialysis with the first extension tube connects to the arterial patient connector of the dialysis machine, and the second extension tube connects to the venous patient connector of the dialysis machine; and periodically reversing the first and second extension tubes connections to the arterial and venous patient connectors of the dialysis machine in a subsequent hemodialysis. The present disclosure also provides a hemodialysis catheter, comprising a switchable connection indicator indicating connection to arterial or venous flow path. The switchable connection indicator can be integrated with a clamp.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.