Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: In some embodiments, a method for optimal parallel execution of a simulation of a design is provided. A computing device extracts one or more features from the design. The computing device provides at least the one or more features as inputs to one or more machine learning models to determine one or more predictions of execution times. The computing device determines an optimum execution architecture based on the one or more predictions of execution times. The computing device distributes portions of the design for simulation based on the optimum execution architecture. In some embodiments, one or more machine learning models are trained to generate outputs for predicting an optimal parallel execution architecture for simulation of a design.

Abstract: In some embodiments, a method for optimal parallel execution of a simulation of a design is provided. A computing device extracts one or more features from the design. The computing device provides at least the one or more features as inputs to one or more machine learning models to determine one or more predictions of execution times. The computing device determines an optimum execution architecture based on the one or more predictions of execution times. The computing device distributes portions of the design for simulation based on the optimum execution architecture. In some embodiments, one or more machine learning models are trained to generate outputs for predicting an optimal parallel execution architecture for simulation of a design.

Abstract: A fully confined dual frequency optical resonator configured for optical coupling to light having a first frequency ?1. The dual frequency optical resonator includes a plurality of alternating layer pairs configured in a grating configuration, each layer pair having a first layer formed of a first material and a second layer formed of a second material, the first material and second material being different materials. Each layer having a thickness different than a thickness of an adjacent layer to provide thereby aperiodic layer pairs, the thicknesses of adjacent layers being selected to create, via wave interference with each layer, optical resonances at the first frequency ?1 and a second frequency ?2 which is a harmonic of ?1, and to ensure a maximum spatial overlap between confined modes over the materials such that an overall quality factor Q of at least 1000 is achieved.

Abstract: A filter to transmit incident radiation at a predetermined incidence angle includes a plurality of photonic crystal structures disposed substantially along a surface normal direction of the filter. The photonic crystal structure includes a multilayer cell that comprises a first layer having a first dielectric permittivity, and a second layer having a second dielectric permittivity different from the first dielectric permittivity. The first layer and the second layer define a Brewster angle substantially equal to the predetermined incidence angle based on the first dielectric permittivity and the second permittivity. Each photonic crystal structure in the plurality of photonic crystal structures defines a respective bandgap, and the respective bandgaps of the plurality of photonic crystal structures, taken together, cover a continuous spectral region of about 50 nm to about 100 mm.

Abstract: A dual frequency optical resonator configured for optical coupling to light having a first frequency ?1. The dual frequency optical resonator includes a plurality of alternating layer pairs stacked in a post configuration, each layer pair having a first layer formed of a first material and a second layer formed of a second material, the first material and second materials being different materials. The first layer has a first thickness and the second layer has a second thickness, the thicknesses of the first and second layer being selected to create optical resonances at the first frequency ?1 and a second frequency ?2 which is a harmonic of ?1 and the thicknesses of the first and second layer also being selected to enhance nonlinear coupling between the first frequency ?1 and a second frequency ?2.

Abstract: A fiber is provided, including a cladding material that is disposed along a longitudinal-axis fiber length. A plurality of spherical particles are disposed as a sequence along a longitudinal line parallel to the longitudinal fiber axis in at least a portion of the fiber length, and include a spherical particle material that is interior to the fiber cladding material and different than the fiber cladding material. To produce particles, a drawn fiber, having a longitudinal-axis fiber length and including at least one fiber core that has a longitudinal core axis parallel to the longitudinal fiber axis and that is internally disposed to at least one outer fiber cladding layer along the fiber length, is heated for a time that is sufficient to cause a fiber core to break-up into droplets sequentially disposed along the fiber core axis. Fiber cooling solidifies droplets into spherical particles interior to fiber cladding.

Abstract: There is provided a fiber including a cladding material that is disposed along a longitudinal-axis fiber length. A plurality of spherical particles are provided, separated from one another and disposed in a longitudinal line parallel to the longitudinal fiber axis. The particles are in a sequence with controlled periodic spacing between particles along at least a portion of the fiber length. Each spherical particle has a spherical particle material that is embedded within and elementally different than the fiber cladding material.

Abstract: A filter to transmit incident radiation at a predetermined incidence angle includes a plurality of photonic crystal structures disposed substantially along a surface normal direction of the filter. The photonic crystal structure includes a multilayer cell that comprises a first layer having a first dielectric permittivity, and a second layer having a second dielectric permittivity different from the first dielectric permittivity. The first layer and the second layer define a Brewster angle substantially equal to the predetermined incidence angle based on the first dielectric permittivity and the second permittivity. Each photonic crystal structure in the plurality of photonic crystal structures defines a respective bandgap, and the respective bandgaps of the plurality of photonic crystal structures, taken together, cover a continuous spectral region of about 50 nm to about 100 mm.

Abstract: A fiber is provided, including a cladding material that is disposed along a longitudinal-axis fiber length. A plurality of spherical particles are disposed as a sequence along a longitudinal line parallel to the longitudinal fiber axis in at least a portion of the fiber length. Each spherical particle is of a spherical particle material that is interior to and different than the fiber cladding material. The spacing between adjacent spherical particles in the sequence of particles is greater than the spherical particle diameter. Each spherical particle can be provided as a core-shell particle that includes a spherical core that is surrounded by at least one spherical shell. Each spherical particle can be provided with a plurality of azimuthal sections of at least two distinct materials.

Abstract: Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently.

Abstract: A fiber structure for propagating one or more zero group-velocity modes is provided. The fiber structure includes a cladding arrangement comprising a photonic crystal having a complete bandgap at a specified index. A core is formed in a selective region of the cladding arrangement. The core allows the propagation of the one or more group-velocity modes.

Abstract: Techniques and devices are disclosed to provide controlled inter-mode cross-talk in multimode optical waveguides. The structure of a bent multimode optical waveguide can be designed or configured in a way that either substantially minimizes inter-mode cross talk or achieves a desired inter-mode cross-talk. Specific examples based on the disclosed waveguide designs are provided for semiconductor integrated waveguide devices.

Abstract: A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the longitudinal axis and internally disposed to at least one outer fiber cladding material layer along the fiber length. The fiber is fed through a localized heating site having a heating site temperature, T, that is above a melting temperature of the fiber core, with a feed speed, ?f, that melts a portion of the fiber core at the heating site, causing molten droplets to pinch off of fiber core material, one droplet at a time, with a time period of molten droplet formation set by the fiber feed speed, ?f. The fiber is fed through the localized heating site to move the molten droplets out of the heating site and solidify the molten droplets into solid in-fiber particles.

Abstract: According to one example embodiment, there is provided a method and an apparatus to evaluate the credit of a healthcare patient. The example embodiment provides methods and computer systems programmed to use multiple variables that are known about a patient prior to a service being rendered to segment the patient population into finer grained groupings. These finer grained groupings allow financial factors, such as a credit score, to be a more accurate predictor. Also, according to another example embodiment, the model is not a generic model for all patients, but the variables and their parameters are specific to a particular healthcare organization's or facility's patient population. This creates a custom model that further enhances its predictiveness.

Abstract: Techniques and devices are disclosed to provide controlled inter-mode cross-talk in multimode optical waveguides. The structure of a bent multimode optical waveguide can be designed or configured in a way that either substantially minimizes inter-mode cross talk or achieves a desired inter-mode cross-talk. Specific examples based on the disclosed waveguide designs are provided for semiconductor integrated waveguide devices.

Abstract: According to one example embodiment, there is provided a method and an apparatus to evaluate the credit of a healthcare patient. The example embodiment provides methods and computer systems programmed to use multiple variables that are known about a patient prior to a service being rendered to segment the patient population into finer grained groupings. These finer grained groupings allow financial factors, such as a credit score, to be a more accurate predictor. Also, according to another example embodiment, the model is not a generic model for all patients, but the variables and their parameters are specific to a particular healthcare organization's or facility's patient population. This creates a custom model that further enhances its predictiveness.

Abstract: In general, in a first aspect the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.

Abstract: A system for efficient generation of THz radiation is provided that includes a triply-resonant nonlinear photonic resonator coupled to at least one near-infrared (NIR) or optical waveguide and to at least one THz waveguide. The energy traveling through the at least one near-infrared (NIR) or optical waveguide is converted to THz radiation inside the triply-resonant photonic resonator via a nonlinear difference frequency generation (DFG) process.

Abstract: In general, in a first aspect, the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.