Abstract: Methods and apparatuses for manufacturing products having custom graphic designed are disclosed. A method may comprise printing a first order identifier graphic on a substrate material, the first order identifier graphic associated with a first order for a first set of products, printing a first set of one or more graphic designs on the material, the first set of one or more graphic designs associated with the first order, and combining the material with one or more product components to form a first set of products, each of the first set of products being associated with the first customer order and at least one of the products of the first set of products comprising the first order identifier graphic. The method may further comprise packaging the first set of products in a first package wherein the first order identifier graphic is visible through the first package.

Abstract: A portable electrical drilling assembly includes an electric motor rotating a gear contained within a gear box housing, a connector coupling the gear to a splined shaft with the splined shaft extending within and engaging an internal surface of a cutter or reamer with the shaft and cutter/reamer defining a cutter-spline drive, and a pivoting feed mechanism coupled to the gear box housing to move a spindle for receiving the cutter or reamer. The gear rotation rotates the splined shaft and reamer/cutter to drill/ream a hole, with the pivoting of the feed mechanism controlling the depth of the drilled or reamed hole. The separate coupling of the splined shaft and cutter/reamer and interchangeability of cutters/reamers allows the assembly to be used in a confined space while still achieving deep drilling of holes in workpieces. The cutter-spline drive can also be used in other drilling assemblies.

Abstract: An annular hole cutter includes a cutter body having cutting teeth and a plurality of flutes extending from the cutting teeth around a side wall between a first and second end, with the flutes separated from each other by a land. The hole cutter includes side walls defining primary and secondary flutes with each one of the primary flutes defining first and second helix angles, and with each one of the secondary flutes defining a third helix angle and a fourth helix angle, with the second helix angle being greater than the first helix angle.

Abstract: A portable electrical drilling assembly includes an electric motor rotating a gear contained within a gear box housing, a connector coupling the gear to a splined shaft with the splined shaft extending within and engaging an internal surface of a cutter or reamer with the shaft and cutter/reamer defining a cutter-spline drive, and a pivoting feed mechanism coupled to the gear box housing to move a spindle for receiving the cutter or reamer. The gear rotation rotates the splined shaft and reamer/cutter to drill/ream a hole, with the pivoting of the feed mechanism controlling the depth of the drilled or reamed hole. The separate coupling of the splined shaft and cutter/reamer and interchangeability of cutters/reamers allows the assembly to be used in a confined space while still achieving deep drilling of holes in workpieces. The cutter-spline drive can also be used in other drilling assemblies.

Abstract: A portable electrical drilling assembly includes an electric motor rotating a gear contained within a gear box housing, a connector reversibly coupling the gear to a splined shaft with the splined shaft extending within and engaging an internal surface of a cutter or reamer with the shaft and cutter/reamer defining a cutter-spline drive, a pivoting power feed mechanism coupled to the gear box housing, and a spindle coupled to the feed mechanism for receiving the cutter or reamer. The gear rotation rotates the splined shaft and reamer/cutter to drill/ream a hole, with the pivoting of the power feed mechanism controlling the depth of the drilled or reamed hole. The separate coupling of the splined shaft and cutter/reamer and interchangeability of cutters/reamers allows the assembly to be used in a confined space while still achieving deep drilling of holes in workpieces. The cutter-spline drive can be used in other drilling assemblies.

Abstract: A portable electrical assembly includes an electric motor, a power module, and an electric motor power cord. The electric motor power cord is placed within a cavity of a housing of the portable electrical assembly and is operatively connected to the electric motor at first end and to the power module at a second end. The electric motor power cord is configured to move in response to the movement of the electric motor without the creation of sharp bends along its length as the electric motor moves between all of its possible operating positions including an extended position and a resting position and a plurality of intermediate position between the extended and resting position.

Abstract: A method of treating a movement disorder using deep brain stimulation, the method comprising the step of inserting a lead having at least one electrode into the brain of a subject, the lead being inserted along a trajectory from the occipito-temporal or occipito-parietal regions, passing laterally to the posterior horn of the lateral ventricle to contact the subthalamic nucleus, the zona incerta or the globus pallidus.

Abstract: The present invention relates to methods and products for demonstrating that intravenous access devices are substantially or completely void of residual drug products. The methods and products involve the use of colored liquids to allow the visual assessment of whether or not an intravenous device has been flushed.

Abstract: A method of treating a movement disorder using deep brain stimulation, the method comprising the step of inserting a lead having at least one electrode into the brain of a subject, the lead being inserted along a trajectory from the occipito-temporal or occipito-parietal regions, passing laterally to the posterior horn of the lateral ventricle to contact the subthalamic nucleus, the zona incerta or the globus pallidus.

Abstract: A method of treating a movement disorder using deep brain stimulation, the method comprising the step of inserting a lead having at least one electrode into the brain of a subject, the lead being inserted along a trajectory from the occipito-temporal or occipito-parietal regions, passing laterally to the posterior horn of the lateral ventricle to contact the subthalamic nucleus, the zona incerta or the globus pallidus.

Abstract: There is provided a method of reducing or preventing catheter reflux during infusion of a therapeutic agent into a brain of a subject comprising administering the therapeutic agent to a target area of the brain by intermittent infusion at a predetermined interval. There is provided a method of treating a CNS disorder comprising administering a therapeutic agent to a target area of a brain of a subject by intermittent infusion at a predetermined interval. There is also provided a system for reducing or preventing catheter reflux during infusion of a therapeutic agent into a target area of a brain of a subject comprising an infusion device, at least one chronically implanted intracranial catheter, a monitoring device configured to monitor the target area of the brain after each infusion, and a determination unit configured to determine whether a predetermined interval is acceptable.

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to auto-immunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: providing an antibody preparation, providing at least one expression library, identifying antigens which bind, screening the identified antigens, identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.

Abstract: An intervertebral joint prosthesis having a ball component (22) for engagement with a first vertebra (26) and a trough component (24) for engagement with a second vertebra (27) adjacent to the first vertebra is disclosed. The trough component (24) includes a generally concave surface (50) having a substantially flat portion (52). When the ball component (22) and the trough component (24) are engaged to their respective vertebrae, the ball component (72) and the trough component (24) engage each other, permitting rotation and translation of the vertebrae with respect to each other. Both components include a flange (34, 56) for engaging a vertebra. The invention also contemplates a method for and a tool for use in implanting a two-piece intervertebral joint prosthesis.

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to auto-immunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: providing an antibody preparation, providing at least one expression library, identifying antigens which bind, screening the identified antigens, identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps:—providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—screening said at least one expression library with said antibody preparation,—identifying antigens which bind in said screening to antibodies in said antibody preparation,—screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: —providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —screening said at least one expression library with said antibody preparation, —identifying antigens which bind in said screening to antibodies in said antibody preparation, —screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pat

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps:—providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogren, tumor, allergen or tissue or host prone to auto-immunity,—providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity,—screening said at least one expression library with said antibody preparation, identifying antigens which bind in said screening to antibodies in said antibody preparation, —screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathog

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: —providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —screening said at least one expression library with said antibody preparation, —identifying antigens which bind in said screening to antibodies in said antibody preparation, —screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pat

Abstract: A stereoguide including first and second guide elements spaced relative to each other through which instruments are passed along an axis of insertion towards a target; characterised by a first clamp having a clamping position on the axis between the guide elements and the target and a second clamp having a clamping position on the axis of insertion and on the opposite side of the guide elements to the first clamp for clamping instruments passing through the guide elements.

Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: —providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, —screening said at least one expression library with said antibody preparation, —identifying antigens which bind in said screening to antibodies in said antibody preparation, —screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pat