Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

Abstract: A pump system includes a pump and a storage volume in fluid communication with a discharge port of the pump. The pump includes a housing defining a pump bore and a pump piston disposed in sliding engagement with the pump bore, the pump piston being in selective fluid communication with the discharge port of the pump. A method for operating the pump system includes determining a time to drain an amount of a first fluid from the storage volume, and retracting the pump piston within the pump bore at a target retraction rate based at least partly on the time to drain the first fluid from the storage volume.

Abstract: Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

Abstract: Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

Abstract: An apparatus for accurately cutting baitfish at a compound miter angle of forty five degrees. The apparatus automatically centers the bait fish within a transverse well at the bottom of a half pipe tube capable of accommodating various common bait fish sizes. The compound miter cut provided by this apparatus exactly matches the compound miter found within the construction of the Sure Spin Herring Helmet® Angler Innovations. The present apparatus is easily washable and leaves no trace of fish scent between uses as it is constructed from non-absorbing high density polyethylene (HPDE). The apparatus further provides safe usage as downward pressure is applied to the cutting tool and bait fish as the cutting tool blade enters the blade slot groove. The present apparatus is constructed with two half pipe options to accommodate multiple bait fish dimensions.

Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4.

Abstract: Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VL or VH domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA).

Abstract: A fixture for delivering a first fluid over the basin of a sink includes a supply inlet and a delivery outlet for the fluid, the inlet connected to the outlet through a hollow body of the fixture, the hollow body including two straight, hollow metal tubes: a first tube arranged to be mounted next to the basin of the sink in use, and a second tube joined to the wall of the first tube so as to project out over the basin of the sink in use. One or more inserts are provided inside the first metal tube and together define a curved elbow duct inside the first metal tube for guiding the fluid from the first metal tube into the second metal tube. The tubes can be cut at relatively low cost from conventional rolled steel tubing, and the curved elbow duct limits pressure losses inside the first tube.

Abstract: Disclosed is a method of forming chewing gum, the method including providing a pair of rollers, sizing a gum mass into a gum sheet having a substantially uniform first thickness using the pair of rollers, and further sizing the gum sheet to include a substantially uniform final thickness downstream of the pair of rollers, wherein the first thickness is greater than 10% thicker than the final thickness, and the final thickness is between about 0.3 mm to 10 mm.

Abstract: Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VL or VH domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA).

Abstract: The immobilisation of single domain antigen binding fragments of antibodies naturally devoid of light chains, or protein domains functionally equivalent thereto, onto a solid surface through covalent cross-linking is described. The binding fragments are devoid of any appended polypeptide tail or linking group. Materials comprising fragments so immobilised and uses thereof are also described.

Abstract: An integrated circuit, including at least two integrated circuit portions mutually spaced on a single electrically insulating die and at least one coupling region on the die to provide capacitive coupling between the otherwise mutually isolated integrated circuit portions, the integrated circuit portions being formed by a plurality of layers on the single die, the layers including metal and dielectric layers and at least one semiconductor layer; wherein at least one of the dielectric layers extends from the integrated circuit portions across the coupling region and at least a corresponding one of the metal layers and/or at least one semiconductor layer extends from each of the integrated circuit portions and partially across the coupling region to form capacitors therein and thereby provide the capacitive coupling between the integrated circuit portions.

Abstract: A pump system includes a pump and a storage volume in fluid communication with a discharge port of the pump. The pump includes a housing defining a pump bore and a pump piston disposed in sliding engagement with the pump bore, the pump piston being in selective fluid communication with the discharge port of the pump. A method for operating the pump system includes determining a time to drain an amount of a first fluid from the storage volume, and retracting the pump piston within the pump bore at a target retraction rate based at least partly on the time to drain the first fluid from the storage volume.

Abstract: An integrated circuit, including at least two integrated circuit portions mutually spaced on a single electrically insulating die and at least one coupling region on the die to provide capacitive coupling between the otherwise mutually isolated integrated circuit portions, the integrated circuit portions being formed by a plurality of layers on the single die, the layers including metal and dielectric layers and at least one semiconductor layer; wherein at least one of the dielectric layers extends from the integrated circuit portions across the coupling region and at least a corresponding one of the metal layers and/or at least one semiconductor layer extends from each of the integrated circuit portions and partially across the coupling region to form capacitors therein and thereby provide the capacitive coupling between the integrated circuit portions.

Abstract: Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

Abstract: Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

Abstract: An optoelectronic device, including a semiconductor body having a surface to receive photons and a plurality of doped regions of opposite doping polarities, the doped regions extending substantially from the surface of the semiconductor body and into the semiconductor body, and being arranged in one or more pairs of opposite doping polarities such that each pair of doped regions forms a corresponding space charge region having a corresponding electric field therein, the space charge region extending substantially from the surface of the semiconductor body and into the semiconductor body such that photons entering the semiconductor body through the surface and travelling along paths within the space charge region generate electron-hole pairs in the space charge region that are separated in opposing directions substantially orthogonal to the photon paths by the electric field and collected by the corresponding pair of doped regions, thereby providing an electrical current to be conducted from the device.