Abstract: This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimized CLN1 open reading frame.

Abstract: An adjustable support comprising a plurality of support portions, and at least one joint connecting adjacent support portions of the plurality of support portions and configured so that the adjacent support portions can be positioned in different positions relative to one another. The at least one joint comprising a first portion and a second portion, the first portion comprising a polygonal extension and the second portion comprising a polygonal recess for receiving the polygonal extension of the first portion, wherein the polygonal extension can be received in the polygonal recess in different rotational positions to position the adjacent support portions in the different positions relative to one another, and the at least one joint further comprising a retainer to force the first and second portions together.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: A method, system, and/or graphical interface, and/or combination thereof, for reminding of important events. Method embodiments may include one or more of the following steps: identifying at least one contact associated with a user; creating or importing at least one profile associated with the identified at least one contact; determining at least one calendar date related to at least one event associated with each identified at least one contact; converting the at least one created or imported profile to at least one corresponding event profile; receiving instructions from the user associated with the at least one event profile; and sending or not sending, based at least in part on the at least one event profile, a notification to the user associated with one event of the at least one event. In some examples, the at least one event profile may be associated with the at least one determined calendar date.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes and virus vectors comprising the same. The invention further relates to methods of delivering a nucleic acid of interest to an oligodendrocyte in vitro and in vivo, methods of delivering a nucleic acid of interest to an area of the CNS bordering a compromised blood-brain barrier, and methods of treating disorders associated with oligodendrocyte dysfunction using the AAV capsids and virus vectors of the invention.

Abstract: A method, system, and/or graphical interface, and/or combination thereof, for reminding of important events. Method embodiments may include one or more of the following steps: identifying at least one contact associated with a user; creating or importing at least one profile associated with the identified at least one contact; determining at least one calendar date related to at least one event associated with each identified at least one contact; converting the at least one created or imported profile to at least one corresponding event profile; receiving instructions from the user associated with the at least one event profile; and sending or not sending, based at least in part on the at least one event profile, a notification to the user associated with one event of the at least one event. In some examples, the at least one event profile may be associated with the at least one determined calendar date.

Abstract: This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimized CLN1 open reading frame.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: A method of mapping locations of living relatives, including: receiving input from a first living person; identifying, based on at least in part on both the received input and data stored in a database, a second living person that has a family relationship with the first living person; determining a location associated with the second living person; and displaying on a map, based at least in part on the determining, the location associated with the second living person. The identifying may include identifying a first plurality of living persons that includes the second living person that each have a family relationship with the first living person. The determining the location may include determining locations respectively associated with each of the first plurality of living persons. The displaying includes displaying on the map at least some of the particular locations respectively associated with each of the first plurality of living persons.

Abstract: This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimized CLN1 open reading frame.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: In accordance with certain implementations of the present approach, a reduced, element-by-element, data set is transmitted between a robot having a sensor suite and a control system remote from the robot that is configured to display a representation of the environment local to the robot. Such a scheme may be useful in allowing a human operator remote from the robot to perform an inspection using the robot while the robot is on-site with an asset and the operator is off-site. In accordance with the present approach, an accurate representation of the environment in which the robot is situated is provided for the operator to interact with.

Abstract: In some examples a method of diagnosing family traits is describe. the method may include, identifying family members and recording information regarding the identified family members in a first database. In some examples, the identified family members may include at least some living persons from different immediate families. sharing access to the first database with living identified family members. The method may further include updating the recorded information regarding the identified family members and analyzing the updated information regarding the identified family members. In some example, the updated information may include at least one trait of at least some of the identified family members. Some examples of the method may further include providing a summary of the analyzed information.

Abstract: This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimized CLN1 open reading frame.

Abstract: Provided are systems and methods for generating an autonomous 3D inspection plan for an unmanned robot. In an example, the method may include receiving a selection of a plurality of regions of interest with respect to a virtual asset displayed in virtual space, detecting a 3D position of the regions of interest within a coordinate frame of the virtual space, auto-generating a travel path about a physical asset corresponding to the virtual asset by generating a virtual 3D travel path with respect to the virtual asset based on the detected 3D positions of the selected regions of interest within the coordinate frame, aligning the virtual 3D travel path in the virtual space with a physical travel path in a physical space, and outputting a robotic inspection plan comprising the auto-generated physical travel path for the unmanned robot.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: System and methods may evaluate and/or improve target aiming accuracy for a sensor of an Unmanned Aerial Vehicle (“UAV”). According to some embodiments, a position and orientation measuring unit may measure a position and orientation associated with the sensor. A pose estimation platform may execute a first order calculation using the measured position and orientation as the actual position and orientation to create a first order model. A geometry evaluation platform may receive planned sensor position and orientation from a targeting goal data store and calculate a standard deviation for a target aiming error utilizing: (i) location and geometry information associated with the industrial asset, (ii) a known relationship between the sensor and a center-of-gravity of the UAV, (iii) the first order model as a transfer function, and (iv) an assumption that the position and orientation of the sensor have Gaussian-distributed noises with zero mean and a pre-determined standard deviation.

Abstract: A three-dimensional model data store may contain a three-dimensional model of an industrial asset, including points of interest associated with the industrial asset. An inspection plan data store may contain an inspection plan for the industrial asset, including a path of movement for an autonomous inspection robot. An industrial asset inspection platform may receive sensor data from an autonomous inspection robot indicating characteristics of the industrial asset and determine a current location of the autonomous inspection robot along the path of movement in the inspection plan along with current context information. A forward simulation of movement for the autonomous inspection robot may be executed from the current location, through a pre-determined time window, to determine a difference between the path of movement in the inspection plan and the forward simulation of movement along with future context information.

Abstract: Provided are systems and methods for monitoring an asset via an autonomous model-driven inspection. In an example, the method may include storing an inspection plan including a virtually created three-dimensional (3D) model of a travel path with respect to a virtual asset that is created in virtual space, converting the virtually created 3D model of the travel path about the virtual asset into a physical travel path about a physical asset corresponding to the virtual asset, autonomously controlling vertical and lateral movement of the unmanned robot in three dimensions with respect to the physical asset based on the physical travel path and capturing data at one or more regions of interest, and capturing data at one or more regions of interest, and storing information concerning the captured data about the asset.

Abstract: Provided are systems and methods for generating an autonomous 3D inspection plan for an unmanned robot. In an example, the method may include receiving a selection of a plurality of regions of interest with respect to a virtual asset displayed in virtual space, detecting a 3D position of the regions of interest within a coordinate frame of the virtual space, auto-generating a travel path about a physical asset corresponding to the virtual asset by generating a virtual 3D travel path with respect to the virtual asset based on the detected 3D positions of the selected regions of interest within the coordinate frame, aligning the virtual 3D travel path in the virtual space with a physical travel path in a physical space, and outputting a robotic inspection plan comprising the auto-generated physical travel path for the unmanned robot.