Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: Provided are systems and methods for generating an autonomous 3D inspection plan for an unmanned robot. In an example, the method may include receiving a selection of a plurality of regions of interest with respect to a virtual asset displayed in virtual space, detecting a 3D position of the regions of interest within a coordinate frame of the virtual space, auto-generating a travel path about a physical asset corresponding to the virtual asset by generating a virtual 3D travel path with respect to the virtual asset based on the detected 3D positions of the selected regions of interest within the coordinate frame, aligning the virtual 3D travel path in the virtual space with a physical travel path in a physical space, and outputting a robotic inspection plan comprising the auto-generated physical travel path for the unmanned robot.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: System and methods may evaluate and/or improve target aiming accuracy for a sensor of an Unmanned Aerial Vehicle (“UAV”). According to some embodiments, a position and orientation measuring unit may measure a position and orientation associated with the sensor. A pose estimation platform may execute a first order calculation using the measured position and orientation as the actual position and orientation to create a first order model. A geometry evaluation platform may receive planned sensor position and orientation from a targeting goal data store and calculate a standard deviation for a target aiming error utilizing: (i) location and geometry information associated with the industrial asset, (ii) a known relationship between the sensor and a center-of-gravity of the UAV, (iii) the first order model as a transfer function, and (iv) an assumption that the position and orientation of the sensor have Gaussian-distributed noises with zero mean and a pre-determined standard deviation.

Abstract: In accordance with certain implementations of the present approach, a reduced, element-by-element, data set is transmitted between a robot having a sensor suite and a control system remote from the robot that is configured to display a representation of the environment local to the robot. Such a scheme may be useful in allowing a human operator remote from the robot to perform an inspection using the robot while the robot is on-site with an asset and the operator is off-site. In accordance with the present approach, an accurate representation of the environment in which the robot is situated is provided for the operator to interact with.

Abstract: A three-dimensional model data store may contain a three-dimensional model of an industrial asset, including points of interest associated with the industrial asset. An inspection plan data store may contain an inspection plan for the industrial asset, including a path of movement for an autonomous inspection robot. An industrial asset inspection platform may receive sensor data from an autonomous inspection robot indicating characteristics of the industrial asset and determine a current location of the autonomous inspection robot along the path of movement in the inspection plan along with current context information. A forward simulation of movement for the autonomous inspection robot may be executed from the current location, through a pre-determined time window, to determine a difference between the path of movement in the inspection plan and the forward simulation of movement along with future context information.

Abstract: Provided are systems and methods for generating an autonomous 3D inspection plan for an unmanned robot. In an example, the method may include receiving a selection of a plurality of regions of interest with respect to a virtual asset displayed in virtual space, detecting a 3D position of the regions of interest within a coordinate frame of the virtual space, auto-generating a travel path about a physical asset corresponding to the virtual asset by generating a virtual 3D travel path with respect to the virtual asset based on the detected 3D positions of the selected regions of interest within the coordinate frame, aligning the virtual 3D travel path in the virtual space with a physical travel path in a physical space, and outputting a robotic inspection plan comprising the auto-generated physical travel path for the unmanned robot.

Abstract: Provided are systems and methods for monitoring an asset via an autonomous model-driven inspection. In an example, the method may include storing an inspection plan including a virtually created three-dimensional (3D) model of a travel path with respect to a virtual asset that is created in virtual space, converting the virtually created 3D model of the travel path about the virtual asset into a physical travel path about a physical asset corresponding to the virtual asset, autonomously controlling vertical and lateral movement of the unmanned robot in three dimensions with respect to the physical asset based on the physical travel path and capturing data at one or more regions of interest, and capturing data at one or more regions of interest, and storing information concerning the captured data about the asset.

Abstract: A wind-driven spinner is provided. The wind-driven spinner embodies a rotatable display that enables customizable, holographic effects to capture the eye, while also providing adjustable stability and wind capturing controls. The wind-driven spinner may include a plurality of panel assemblies rotatably mounted to an axis shaft by means of two hub bearings. Each panel assembly may be paraboloid shaped so as to provide a leading edge and a trailing edge. Relative to the axis shaft, the leading edge of each panel assembly has a radial outer diameter greater than the radial outer diameter of its trailing edge and an adjacent panel assembly so as to provide at least one, adjustable wind-driven capture profile. Each panel assembly may include a customizable design sheet for providing graphic display area and holographic fabric.

Abstract: The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: A sensor may include a first substrate having a sensing portion defining a sensor thereon and configured to be percutaneously inserted into a patient, and an extracorporeal circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. A second substrate may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes, nucleic acids encoding the capsids, virus vectors and particles comprising the same, methods of producing the vectors, and methods of using the vectors to target oligodendrocytes. The invention further relates to methods of treating a disorder associated with oligodendrocyte dysfunction using the vectors.

Abstract: A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. An electrical circuit may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.

Abstract: A system is provided for managing an amount of stored energy in a powered system. The powered system is configured to complete a mission from an initial stage to a final stage. The system includes a controller including a memory configured to store a plurality of handling stages. The controller is configured to determine the stored energy at the initial stage based upon the initial stage and a handling stage positioned between the initial stage and the final stage, and selected from among the plurality of handling stages stored in memory. The stored energy is necessary to propagate the powered system from the initial stage to the handling stage upon the occurrence of an anomaly in the powered system. Additionally, a method and computer readable media are provided for managing an amount of stored energy in a powered system.

Abstract: A wholly aromatic thermotropic liquid crystalline polymer and compositions including the liquid crystalline polymer are described. The polymer composition can include the liquid crystalline polymer and a fibrous filler, e.g., a chopped glass or milled glass fibrous filler. The compositions are capable of exhibiting excellent mechanical properties. The liquid crystalline polymer provides desirable characteristics with the incorporation of little or no naphthenic acids in the polymer backbone.

Abstract: The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.

Abstract: A wind-driven spinner is provided. The wind-driven spinner embodies a rotatable display that enables customizable, holographic effects to capture the eye, while also providing adjustable stability and wind capturing controls. The wind-driven spinner may include a plurality of panel assemblies rotatably mounted to an axis shaft by means of two hub bearings. Each panel assembly may be paraboloid shaped so as to provide a leading edge and a trailing edge. Relative to the axis shaft, the leading edge of each panel assembly has a radial outer diameter greater than the radial outer diameter of its trailing edge and an adjacent panel assembly so as to provide at least one, adjustable wind-driven capture profile. Each panel assembly may include a customizable design sheet for providing graphic display area and holographic fabric.