Patents by Inventor Steven H. Bass

Steven H. Bass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8496935
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: July 30, 2013
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8491899
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: July 23, 2013
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8445230
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: May 21, 2013
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 8377681
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: February 19, 2013
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8318176
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: November 27, 2012
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8283447
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: October 9, 2012
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
    Publication number: 20120252681
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Application
    Filed: December 2, 2011
    Publication date: October 4, 2012
    Applicant: CODEXIS MAYFLOWER HOLDINGS, LLC
    Inventors: Stephen del Cardayre, Matthew Tobin, Willem P.C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswaran Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8268587
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: September 18, 2012
    Assignee: Perseid Therapeutics LLC
    Inventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • Antibody diversity generation
    Patent number: 8252727
    Abstract: Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: August 28, 2012
    Assignee: Maxygen, Inc.
    Inventors: Erik Karrer, Steven H. Bass, Robert Whalen, Philip A. Patten
  • POLYPEPTIDE INHIBITORS OF VLA4
    Publication number: 20120135912
    Abstract: The invention provides novel 2D-VCAM-1 variant polypeptides and conjugates thereof that bind human VLA4. The invention also provides related polynucleotides, compositions, vectors, host cells, and methods.
    Type: Application
    Filed: May 10, 2011
    Publication date: May 31, 2012
    Applicant: PERSEID THERAPEUTICS LLC
    Inventors: MADAN M. PAIDHUNGAT, AMULYA NANISETTI, THOMAS BOUQUIN, KIM VILBOUR ANDERSEN, STEVEN J. CHAPIN, CLAUS KREBBER, RONG A. FAN, DANIEL MALASHOCK, AMY BRIDEAU-ANDERSEN, ERIK KARRER, BRUCE DEVENS, STEVEN H. BASS
  • OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION
    Publication number: 20120040871
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: September 23, 2011
    Publication date: February 16, 2012
    Applicant: CODEXIS MAYFLOWER HOLDINGS, LLC
    Inventors: Andreas Crameri, Willem PC Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A Patten
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 8076138
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: December 13, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
  • Immunosuppressive polypeptides and nucleic acids
    Patent number: 8071095
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: December 6, 2011
    Assignee: Perseid Therapeutics, LLC
    Inventors: Erik E Karrer, Madan M Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J Chapin
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 8058001
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: November 15, 2011
    Assignee: Codexis Mayflower Holdings LLC
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, John E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 8029988
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: October 4, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Integrated systems and methods for diversity generation and screening
    Patent number: 8014961
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: September 6, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Steven H. Bass, Simon Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy S. Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephan J. Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
  • EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
    Publication number: 20110190140
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Application
    Filed: October 15, 2009
    Publication date: August 4, 2011
    Applicant: Maxygen, Inc.
    Inventors: Stephen del Cardayre, Matthew Tobin, Willem P.C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
    Publication number: 20110182898
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 28, 2011
    Applicant: PERSEID THERAPEUTICS LLC
    Inventors: ERIK E. KARRER, MADAN M. PAIDHUNGAT, STEVEN H. BASS, MARGARET NEIGHBORS, JUHA PUNNONEN, STEVEN J. CHAPIN
  • IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
    Publication number: 20110177071
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Application
    Filed: March 10, 2011
    Publication date: July 21, 2011
    Applicant: Perseid Therapeutics LLC
    Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
  • IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
    Publication number: 20110166324
    Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
    Type: Application
    Filed: January 21, 2011
    Publication date: July 7, 2011
    Applicant: Perseid Therapeutics LLC
    Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin