Patents by Inventor Steven H. Bass
Steven H. Bass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110159542Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 30, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110130546Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110129875Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20100260759Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: April 20, 2010Publication date: October 14, 2010Applicant: PERSEID THERAPEUTICS LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin, Sridhar Viswanathan, Brent R. Larsen
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Patent number: 7794718Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: October 15, 2008Date of Patent: September 14, 2010Assignee: Perseid Therapeutics, LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20100184627Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.Type: ApplicationFiled: September 11, 2009Publication date: July 22, 2010Applicant: Maxygen, Inc.Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, John E. Ness, Claes Gustafsson, Phillip A. Patten
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Patent number: 7629170Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.Type: GrantFiled: August 17, 2006Date of Patent: December 8, 2009Assignee: Maxygen, Inc.Inventors: Stephen delCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
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Patent number: 7619067Abstract: The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.Type: GrantFiled: May 17, 2006Date of Patent: November 17, 2009Assignee: Maxygen, Inc.Inventors: Madan M. Paidhungat, Ian J. Sas, Thomas Bouquin, David Lin, Teddy Chen, Douglas Guptill, Amy Brideau-Andersen, Steven H. Bass, Phillip A. Patten
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Publication number: 20090258031Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: October 15, 2008Publication date: October 15, 2009Applicant: MAXYGEN, INC.Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin, Sridhar Viswanathan, Brent R. Larsen
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Patent number: 7462469Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: GrantFiled: May 23, 2002Date of Patent: December 9, 2008Assignee: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Publication number: 20080226597Abstract: The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.Type: ApplicationFiled: May 17, 2006Publication date: September 18, 2008Applicant: MAXYGEN, INC.Inventors: Madan M. PAIDHUNGAT, Ian J. SAS, Thomas BOUQUIN, David LIN, Teddy CHEN, Douglas GUPTILL, Amy BRIDEAU-ANDERSEN, Steven H. BASS, Phillip A. PATTEN
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Publication number: 20080207459Abstract: Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.Type: ApplicationFiled: February 5, 2008Publication date: August 28, 2008Inventors: Erik Karrer, Steven H. Bass, Robert Whalen, Phillip A. Patten
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Publication number: 20080171668Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.Type: ApplicationFiled: November 30, 2007Publication date: July 17, 2008Applicant: Maxygen, Inc.Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
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Publication number: 20040001849Abstract: This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.Type: ApplicationFiled: March 7, 2003Publication date: January 1, 2004Applicant: Maxygen, Inc., a Delaware corporationInventors: Juha Punnonen, Steven H. Bass, Robert Gerald Whalen, Russell Howard, Willem P.C. Stemmer
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Patent number: 6576757Abstract: This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.Type: GrantFiled: November 28, 2000Date of Patent: June 10, 2003Assignee: Maxygen, Inc.Inventors: Juha Punnonen, Steven H. Bass, Robert Gerald Whalen, Russell Howard, Willem P. C. Stemmer
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Patent number: 6569435Abstract: This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.Type: GrantFiled: November 28, 2000Date of Patent: May 27, 2003Assignee: Maxygen, Inc.Inventors: Juha Punnonen, Steven H. Bass, Robert Gerald Whalen, Russell Howard, Willem P. C. Stemmer
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Publication number: 20030064393Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: May 23, 2002Publication date: April 3, 2003Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Patent number: 6541011Abstract: This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.Type: GrantFiled: February 10, 1999Date of Patent: April 1, 2003Assignee: Maxygen, Inc.Inventors: Juha Punnonen, Steven H. Bass, Robert Gerald Whalen, Russell Howard, Willem P. C. Stemmer
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Publication number: 20030054384Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: May 23, 2002Publication date: March 20, 2003Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longschamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Publication number: 20030054390Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.Type: ApplicationFiled: July 15, 2002Publication date: March 20, 2003Applicant: Maxygen, Inc.Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten