Patents by Inventor Steven H. Spergel

Steven H. Spergel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazoquinoxaline protein tyrosine kinase inhibitors
    Patent number: 6239133
    Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: May 29, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Substituted biphenyl isoxazole sulfonamides
    Patent number: 5846990
    Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each directly bonded to a ring carbon and are each independently(a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.5 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.5 ;(i) --Z.sup.4 --NR.sup.6 R.sup.7 ;(j) --Z.sup.4 --N(R.sup.10)--Z.sup.5 --NR.sup.8 R.sup.9 ; or(k) R.sup.3 and R.sup.4 together may also be alkylene or alkenylene, either of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3, completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: December 8, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Natesan Murugesan, Joel C. Barrish, Steven H. Spergel
  • Retrocarbamate protease inhibitors
    Patent number: 5492910
    Abstract: The invention discloses compounds of the formula ##STR1## are disclosed as HIV protease inhibitors.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: February 20, 1996
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
    Patent number: 5481011
    Abstract: The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: January 2, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ping Chen, Peter T. W. Cheng, Steven H. Spergel, Joel C. Barrish, John K. Thottathil, Robert Zahler, Richard P. Polniaszek, Xuebao Wang
  • Tetrahydroethanonaphthaleneamine derivatives
    Patent number: 5276026
    Abstract: Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R.sub.1 and R.sub.2 are as defined herein, are novel calcium channel blockers.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: January 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Tetrahydroethanonaphthaleneamine derivatives
    Patent number: 5202486
    Abstract: Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R.sub.1 and R.sub.2 are as defined herein, are novel calcium channel blockers.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: April 13, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joel C. Barrish, Steven H. Spergel