Patents by Inventor Steven Hugh

Steven Hugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8639319
    Abstract: An ECG monitoring system for ambulatory patients includes a small multi-electrode patch that adhesively attaches to the chest of a patient. A reusable battery-powered ECG monitor clips onto the patch and receives patient electrical signals from the electrodes of the patch. A processor continuously processes received ECG signals and stores the signals in memory in the monitor. Processed ECG signals and cardiac event information are sent wirelessly to a cellphone handset for relay to a monitoring center. The ECG monitor is contained in a watertight sealed case with only electrical contacts on the outside of the case. The electrical contacts electrically couple the ECG monitor to the electrodes of the patch during patient monitoring and to a charger during recharge of the battery.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: January 28, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Steven Hugh, Earl Herleikson, Shannon Fong, Thomas Solosko, Brett Cross
  • Patent number: 8560040
    Abstract: A biomedical electrode patch having improved resistance to capacitive coupling to extraneous electric fields. The patch includes a conductive shield and a contact portion formed on an upper surface thereof. The contact portion extends through the film layer and contacts an electrode formed of a material suitable for conducting electrical signals from a patient. Conductive traces formed on the lower surface of the tab extend to contact pads. A nonconductive layer is printed over the traces and can have a shield formed thereon.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: October 15, 2013
    Assignee: Koninklijke Philips N.V.
    Inventors: Stacy Gehman, Earl Herleikson, Steven Hugh, Thomas Lyster, Thomas Solosko
  • Publication number: 20130112941
    Abstract: Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell and insulator coating are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core. An insulator layer encapsulates the nanocrystalline shell and anisotropic nanocrystalline core.
    Type: Application
    Filed: May 31, 2012
    Publication date: May 9, 2013
    Inventors: Juanita Kurtin, Matthew J. Carillo, Steven Hughes, Brian Theobald, Colin Reese, Oun-Ho Park, Georgeta Masson
  • Publication number: 20130112940
    Abstract: Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core.
    Type: Application
    Filed: May 31, 2012
    Publication date: May 9, 2013
    Inventors: Juanita Kurtin, Matthew J. Carillo, Steven Hughes
  • Publication number: 20130060115
    Abstract: A biomedical electrode patch having improved resistance to capacitive coupling to extraneous electric fields. The patch includes a conductive shield and a contact portion formed on an upper surface thereof The contact portion extends through the film layer and contacts an electrode formed of a material suitable for conducting electrical signals from a patient. Conductive traces formed on the lower surface of the tab extend to contact pads. A nonconductive layer is printed over the traces and can have a shield formed thereon.
    Type: Application
    Filed: November 5, 2012
    Publication date: March 7, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Stacy GEHMAN, Earl HERLEIKSON, Steven HUGH, Thomas LYSTER, Thomas SOLOSKO
  • Publication number: 20110021937
    Abstract: An ECG monitoring system for ambulatory patients includes a small multi-electrode patch that adhesively attaches to the chest of a patient. A reusable battery-powered ECG monitor clips onto the patch and receives patient electrical signals from the electrodes of the patch. A processor continuously processes received ECG signals and stores the signals in memory in the monitor. Processed ECG signals and cardiac event information are sent wirelessly to a cellphone handset for relay to a monitoring center. The ECG monitor is contained in a watertight sealed case with only electrical contacts on the outside of the case. The electrical contacts electrically couple the ECG monitor to the electrodes of the patch during patient monitoring and to a charger during recharge of the battery.
    Type: Application
    Filed: March 4, 2009
    Publication date: January 27, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Steven Hugh, Earl Herleikson, Shannon Fong, Thomas Solosko, Brett Cross
  • Publication number: 20080033148
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Application
    Filed: July 27, 2007
    Publication date: February 7, 2008
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven Hughes, Yasmin Chandrasekher
  • Publication number: 20080025946
    Abstract: The present invention provides methods for use of IL-21 in combination with a tyrosine kinase inhibitor (TKI) in treatment of diseases in which inhibition of phosphorylation via TK inhibition and modulation of immune function play a clinically beneficial role. These diseases include, but are not limited to, cancers, such as renal cell carcinoma and metastatic melanoma.
    Type: Application
    Filed: July 13, 2007
    Publication date: January 31, 2008
    Inventors: Pallavur Sivakumar, Diana Hausman, Steven Hughes, Eric Sievers, Dennis Miller
  • Publication number: 20070299247
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: July 26, 2007
    Publication date: December 27, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven Hughes
  • Publication number: 20070178063
    Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
    Type: Application
    Filed: October 6, 2006
    Publication date: August 2, 2007
    Inventors: Wayne Kindsvogel, Steven Hughes, Richard Holly, Christopher Clegg, Donald Foster, Rebecca Johnson, Mark Heipel, Pallavur Sivakumar
  • Publication number: 20070128161
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 12, 2006
    Publication date: June 7, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070122382
    Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
    Type: Application
    Filed: October 6, 2006
    Publication date: May 31, 2007
    Inventors: Wayne Kindsvogel, Steven Hughes, Richard Holly, Christopher Clegg, Donald Foster, Rebecca Johnson, Mark Heipel, Pallavur Sivakumar
  • Publication number: 20070086980
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 11, 2006
    Publication date: April 19, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070049548
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 11, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070048273
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070049549
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 11, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070048269
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 11, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070048267
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070048272
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly
  • Publication number: 20070048266
    Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Andrew Nelson, Steven Hughes, Richard Holly