Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Abstract: A food processing apparatus includes a tank having an inlet end and a discharge end and at least one baffle divides the tank into a first compartment and a second compartment, wherein a temperature of the first compartment is greater than a temperature of the second compartment. A first drum is rotatably mounted within the first compartment of the tank such that a heat transfer medium contained in the first compartment of the tank will enter the first drum and a second drum is rotatably mounted within the second compartment of the tank such that a cool transfer medium contained in the second compartment of the tank will enter the second drum. A food product transfer device transfers food product from the first drum to the second drum.

Abstract: Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract: Disclosed herein are nanostructures comprising distinct dots and rods coupled through potential barriers of tuneable height and width, and arranged in three dimensional space at well defined angles and distances. Such control allows investigation of potential applications ranging from quantum information processing to artificial photosynthesis.

Abstract: The present invention relates to blocking the activity of IL-20 receptor polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 receptor antibodies and binding partners, including anti-IL-20RA, anti-IL-20RB and anti-IL-20RA/IL-20RB antibodies as well as methods for antagonizing IL-20RA and IL-20RB, either individually or together, using such antibodies and binding partners.

Abstract: The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.

Abstract: An apparatus for peeling or cleaning food product that includes a plurality of rollers each coupled to a drive box, preferably a gear box, by a vibration dampening coupling that preferably is disposed exteriorly of one end of the roller and part of the frame of the machine that supports the roller. A drive that preferably is an electric motor is attached to the drive box such that a plurality of rollers is driven thereby. Such an arrangement enables rollers to be driven at speeds of 600 RPM and preferably 750 RPM or faster, which decreases processing time and increases capacity and throughput. In a method of operation, each roller is driven at a speed of 750 RPM or greater to peel or clean food product before being discharged from the machine. In one preferred method, the rollers are driven at speeds between 900 and 1200 RPM.

Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.

Abstract: An alarm system for detecting attempted theft of an article includes means incorporated in the article itself and arranged to transmit and to continuing transmitting an alarm signal when the article is removed from its original location. An example of the alarm system provides an audible alarm, or transmitted alarm, and is arranged to be operated when a thief removes or attempts to remove a car radio, cassette player, compact disc player or the like from a car. Unauthorized removal of the unit from a car is detected by the consequent breaking of an electrical circuit which may be the power supply connections to the radio from the car electrical system or may be the connections to the loudspeakers or the radio aerial.

Abstract: An aqueous gloss emulsion paint comprises a dispersion of structured composite particles, said structured particles comprising an association of particles of inorganic pigment and polymeric particles. The polymeric particles are formed from a polymer or copolymer having a minimum film forming temperature not greater than 50.degree. C. The component particles of the composite particles are held in association as a result of surface charges on the particles said surface charges on the polymeric particles being of opposite sign to the surface charge on the particles of inorganic pigment. The ratio of polymeric particles to particles of inorganic pigment in the composite particles is from 0.5:1 to 6:1 by volume.

Abstract: A pigmentary material comprises particulate titanium dioxide the particles of which have been treated with a polymeric hindered amine stabiliser. The stabiliser is a polymer having a main chain substantially free of acidic groups and having hindered amine stabilising groups. The stabilising groups comprise at least 35 per cent by weight of the polymer. Preferably, the titanium dioxide particles are also treated with an organic compound such as a polyhydric alcohol, an alkanolamine, a polysiloxane or a fatty acid.

Abstract: In a data processing system that uses segmentation and paging to access data information such as in a virtual memory machine, the cache store need not be entirely cleared each time an I/O operation is performed or each time the data in the cache has a possibility of being incorrect. With segmentation and paging, only a portion of the cache store need be cleared when a new page is obtained from the virtual memory. The entire cache store is cleared only when a new segment is indicated by the instruction. The cache store is selectively cleared of the information from the page whose data information is no longer needed by addressing each level of an associative tag directory to the cache store. The columns of each level are compared to the page address and if a comparison is signaled that column of the addressed level is cleared by clearing the flag indicating the full status of the column in the addressed level. Each level of the tag directory is addressed.