Abstract: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase. Also disclosed are pharmaceutical compositions, methods of using and making the same.

Abstract: A system and method for providing a personalized advertisement for a good or service for display to a user is described. The system includes a communications device operated by the user; a virtual person database comprising information about the user; and a search engine useful for finding advertisements of interest to the user and generating personalized advertisements for display on the communications device.

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula IV: wherein the variables are as defined herein.

Abstract: The present invention is directed to a method of controlling a communications link and apparatus configured to perform this method. This invention is particularly related to but in no way limited to MIMO (multiple inputs multiple outputs) wireless communications systems. The method comprises the steps of determining at the receiver the quality of the communications link and based on this, selecting a group of transmission parameters and an element from this group. These selections are then communicated to the transmitter. The transmission parameter may be the transmission configuration such as the modulation and coding scheme. The invention minimizes the required feedback signalling from the receiver to the transmitter by exploiting temporal correlation of the parameter being controlled, while allowing rapid selection of the parameter.

Abstract: An illustrative embodiment of a computer-implemented process for detecting code breakage using source code change history receives a point in time within an identified range of time to form a selected time, receives a set of source files associated with the a selected time, receives a set of history files associated with the received set of source files and initializes a workspace in a sandbox using the set of source files and the set of history files. The computer-implemented process incrementally executes the received set of source files from the selected time forward, determines whether a code break occurs and responsive to a determination that the code break occurs, presents a list of files. The computer-implemented process receives an identified file from the list of files to form a suspect file, and receives a correction for the suspect file.

Abstract: A distributed refrigeration appliance system for use in a residential kitchen and other locations in a dwelling and includes multiple separate refrigeration appliance modules, a central cooling system and a cooling circuit. The system can also include one or more satellite stations having a heat exchanger and arranged for supplying chilled air to one or more refrigeration appliance modules. One or more refrigeration appliance modules can include a thermal cascade cooling device to cool the module to lower temperatures than the cooling circuit can attain. One or more refrigeration appliance modules can be refrigeration/storage modules that can provide refrigerated, unconditioned or heated storage space. The central cooling system can be a vapor compression system having a refrigerant circuit connecting the modules. Alternately, the central cooling system can cool a secondary cooling medium circuit.

Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

Abstract: A mask system for use between a patient and a device to deliver a breathable gas to the patient includes a mouth cushion, a pair of nasal prongs, an elbow, and a headgear assembly. The mouth cushion is structured to sealingly engage around an exterior of a patient's mouth in use, and the pair of nasal prongs are structured to sealingly communicate with nasal passages of a patient's nose in use. The elbow delivers breathable gas to the patient. The headgear assembly maintains the mouth cushion and the nasal prongs in a desired position on the patient's face. The headgear assembly provides a substantially round crown strap that cups the parietal bone and occipital bone of the patient's head in use.

Abstract: A new lithographic process comprises reducing the linewidth of an image while maintaining the lithographic process window, and using this process to fabricate pitch split structures comprising nm order (e.g., about 22 nm) node semiconductor devices. The process comprises applying a lithographic resist layer on a surface of a substrate and patterning and developing the lithographic resist layer to form a nm order node image having an initial line width. Overcoating the nm order node image with an acidic polymer produces an acidic polymer coated image. Heating the acidic polymer coated image gives a heat treated coating on the image, the heating being conducted at a temperature and for a time sufficient to reduce the initial linewidth to a subsequent narrowed linewidth. Developing the heated treated coating removes it from the image resulting in a free-standing trimmed lithographic feature on the substrate. Optionally repeating the foregoing steps further reduces the linewidth of the narrowed line.

Abstract: A display assembly includes a transparent cover piece, a display shroud having a contact structure arranged to face the transparent cover piece, an interface subassembly mounted on the display shroud, an electronics board shroud having a support member and a connection feature, and a biasing member operably engaged between the display shroud and the electronics board shroud. The connection feature mechanically connects the electronics board shroud to the display shroud while permitting axial displacement and rotation therebetween. The biasing member rests on the support member of the electronics board shroud, and the biasing member is configured to urge the contact structure of the display shroud into physical contact with the transparent cover piece. The interface subassembly includes a display circuit for providing a digital display and a touch circuit for providing touch actuation at or near the digital display through the transparent cover piece.

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).

Abstract: A method for predicting harvestable biomass yield in a crop comprising: genotyping a sample obtained from a crop plant for one or more markers genetically linked to a polynucleotide sequence having at least 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 97, 98, 99 or 100% identity to SEQ BD NO 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25, whereby the markers individually or collectively identify a haplotype associated with yield in a plurality of crop plants and correlating the haplotype with the harvested biomass yield.

Abstract: High rate and high crush-strength adsorbent particles and collections of such particles, and particularly LiLSX particles, are provided. A binder is employed in the form of a colloidal solution during the method of manufacture. Suitable binders include various silica binders. The particles are made using the steps of mixing, agglomeration, calcination and in the case of certain adsorbents such as LiX and LiLSX, ion exchange and activation. When the adsorption rate is expressed in the form SCRR/?p (mmol mm2/g s), desirable collections of adsorbent particles can have values of at least 4.0 for the highly-exchanged Li (at least 90% Li exchanged) form of the collection of particles and can further be characterized by particles having average crush strengths of at least 0.9 lbf for particles having an average diameter of at least about 1.0 mm.

Abstract: Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be used to practice the methods are also disclosed.

Abstract: The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Abstract: A method and apparatus for transferring identity information for temporary use by a wireless device, visiting a foreign operator network, is provided. The wireless device is identified as foreign to the operator network and presented with an opportunity to download a temporary identity which is recognized by the operator network as belonging to a local subscriber. The temporary identity, once installed on the wireless device, makes the wireless device appear as a local subscriber. Upon termination of use, the temporary identity is returned to a pool and usable for another wireless device.

Abstract: A method for installing a paver system includes positioning a first grid substrate adjacent to a second grid substrate, the first and second grid substrates form a paver support surface. At least the first grid substrate includes an integrated boundary ridge extending along the first paver support surface. The first grid substrate is interlocked with the second grid substrate with a first paver piece bridging the first and second grid substrates to form a paver linkage. Movement of at least the first paver piece is arrested beyond the integrated boundary ridge by directly or indirectly engaging at least the first paver piece against the integrated boundary ridge. In another example, movement of the first paver piece is arrested by anchoring at least the first paver piece on the first and second paver support surfaces through distribution of forces incident on at least the first paver piece through the paver linkage.