Patents by Inventor Steven Jungles

Steven Jungles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250120935
    Abstract: The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.
    Type: Application
    Filed: December 26, 2024
    Publication date: April 17, 2025
    Inventors: John KLOPP, Gabrielle Morris, Emil Kakkis, Steven Jungles
  • Publication number: 20250073319
    Abstract: In certain aspects, the present invention provides novel lyophilized formulations of ENPP1 polypeptides, as well as methods for using such lyophilized formulations and reconstituted formulations of ENPP1 to treat an indication associated an ENPP1 deficiency. The formulations and methods provided herein are useful in treating diseases associated with an ENPP1 deficiency such as pathological calcification or pathological ossification.
    Type: Application
    Filed: March 21, 2024
    Publication date: March 6, 2025
    Inventor: Steven Jungles
  • Publication number: 20240148907
    Abstract: The present disclosure provides, among other things, vectors for expression of ENPP1 or ENPP3 in vivo and methods for the treatment of diseases of calcification and ossification in a subject.
    Type: Application
    Filed: April 7, 2023
    Publication date: May 9, 2024
    Inventors: Steven Jungles, Demetrios Braddock
  • Publication number: 20230313158
    Abstract: In certain aspects, the present invention provides novel soluble ENPP1 or ENPP3 polypeptides, as well as compositions and methods for using those variants to treat an indication associated an ENPP1 or ENPP3 deficiency. The compositions and methods provided herein are useful in treating diseases associated with an ENPP1 or ENPP3 deficiency such as pathological calcification or pathological ossification.
    Type: Application
    Filed: December 8, 2022
    Publication date: October 5, 2023
    Inventors: Zhiliang Cheng, Demetrios Braddock, Paul Stabach, Steven Jungles
  • Publication number: 20230031809
    Abstract: The present disclosure provides, among other things, vectors for expression of ENPP1 or ENPP3 in vivo and methods for the treatment of diseases of calcification and ossification in a subject.
    Type: Application
    Filed: August 25, 2022
    Publication date: February 2, 2023
    Inventors: Steven Jungles, Demetrios Braddock
  • Publication number: 20210187067
    Abstract: The present disclosure provides, among other things, vectors for expression of ENPP1 or ENPP3 in vivo and methods for the treatment of diseases of calcification and ossification in a subject.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 24, 2021
    Inventors: Steven Jungles, Demetrios Braddock
  • Patent number: 10889607
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: January 12, 2021
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kakkis, Steven Jungles, He Zhao
  • Patent number: 10457701
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 29, 2019
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kakkis, Steven Jungles, He Zhao
  • Patent number: 10065981
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: September 4, 2018
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kakkis, Steven Jungles, He Zhao
  • Patent number: 9937243
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: April 10, 2018
    Assignee: Ultrageny x Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • Patent number: 9687532
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: June 27, 2017
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • Publication number: 20160289175
    Abstract: The present invention provides novel creatine analogs useful for treating any creatine deficiency disorders and methods of treating and preventing creatine deficiencies utilizing the present compounds and the pharmaceutical compositions or formulations thereof. Certain embodiments seek to increase the lipophilicty of novel creatine analogs with the goal of improving their bioavailability.
    Type: Application
    Filed: November 5, 2014
    Publication date: October 6, 2016
    Inventors: Steven Jungles, Yiumo Chan, Emil Kakkis
  • Patent number: 9457067
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 4, 2016
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • Patent number: 9457068
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 4, 2016
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • Patent number: 9221858
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: December 29, 2015
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kakkis, Steven Jungles, He Zhao
  • Patent number: 8840926
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: September 23, 2014
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kaskkis, Steven Jungles, He Zhao
  • Patent number: 8178670
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin of Formula I in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: May 15, 2012
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Müller, Philipp Schmidt, Stefan Kaiser
  • Patent number: 8003126
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: August 23, 2011
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi
  • Publication number: 20090198055
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Application
    Filed: January 6, 2009
    Publication date: August 6, 2009
    Applicant: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Muller, Philipp Schmidt, Stefan Kaiser
  • Patent number: 7566462
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: July 28, 2009
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark A. Henderson, Victoria Sluzky, Robert Baffi