Patents by Inventor Steven Jungles

Steven Jungles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIALYLATED GLYCOPROTEIN COMPOSITIONS AND USES THEREOF
    Publication number: 20170326210
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 16, 2017
    Inventors: Steven JUNGLES, Gabrielle MORRIS, Jeff GRUBB, Michael VELLARD, Emil D. KAKKIS
  • Sialylated glycoprotein compositons and uses thereof
    Patent number: 9687532
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: June 27, 2017
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • SIALYLATED GLYCOPROTEIN COMPOSITONS AND USES THEREOF
    Publication number: 20160367646
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Application
    Filed: August 30, 2016
    Publication date: December 22, 2016
    Inventors: Steven JUNGLES, Gabrielle MORRIS, Jeff GRUBB, Michael VELLARD, Emil D. KAKKIS
  • SIALIC ACID ANALOGS
    Publication number: 20160297846
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Application
    Filed: November 18, 2015
    Publication date: October 13, 2016
    Applicant: ULTRAGENYX PHARMACEUTICAL INC.
    Inventors: Emil KAKKIS, Steven JUNGLES, He ZHAO
  • CREATINE ANALOGS AND THE USE THEREOF
    Publication number: 20160289175
    Abstract: The present invention provides novel creatine analogs useful for treating any creatine deficiency disorders and methods of treating and preventing creatine deficiencies utilizing the present compounds and the pharmaceutical compositions or formulations thereof. Certain embodiments seek to increase the lipophilicty of novel creatine analogs with the goal of improving their bioavailability.
    Type: Application
    Filed: November 5, 2014
    Publication date: October 6, 2016
    Inventors: Steven Jungles, Yiumo Chan, Emil Kakkis
  • Sialylated glycoprotein compositions and uses thereof
    Patent number: 9457068
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 4, 2016
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • Sialylated glycoprotein compositions and uses thereof
    Patent number: 9457067
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 4, 2016
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Steven Jungles, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • SOLID COMPOSITIONS OF TRIGLYCERIDES AND USES THEREOF
    Publication number: 20160243071
    Abstract: The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.
    Type: Application
    Filed: November 14, 2014
    Publication date: August 25, 2016
    Inventors: John KLOPP, Gabrielle MORRIS, Emil KAKKIS, Steven JUNGLES
  • Sialic acid analogs
    Patent number: 9221858
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: December 29, 2015
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kakkis, Steven Jungles, He Zhao
  • SIALYLATED GLYCOPROTEIN COMPOSITIONS AND USES THEREOF
    Publication number: 20150366951
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Application
    Filed: September 10, 2015
    Publication date: December 24, 2015
    Inventors: Steven JUNGLES, Gabrielle MORRIS, Jeff GRUBB, Michael VELLARD, Emil D. KAKKIS
  • SIALYLATED GLYCOPROTEIN COMPOSITIONS AND USES THEREOF
    Publication number: 20150250860
    Abstract: The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
    Type: Application
    Filed: March 5, 2015
    Publication date: September 10, 2015
    Inventors: Steven JUNGLES, Gabrielle Morris, Jeff Grubb, Michael Vellard, Emil D. Kakkis
  • SIALIC ACID ANALOGS
    Publication number: 20150038693
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Application
    Filed: August 15, 2014
    Publication date: February 5, 2015
    Applicant: ULTRAGENYX PHARMACEUTICAL INC.
    Inventors: Emil KAKKIS, Steven JUNGLES, He ZHAO
  • Sialic acid analogs
    Patent number: 8840926
    Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: September 23, 2014
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Emil Kaskkis, Steven Jungles, He Zhao
  • Method of synthesizing tetrahydrobiopterin
    Patent number: 8178670
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin of Formula I in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: May 15, 2012
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Müller, Philipp Schmidt, Stefan Kaiser
  • Stable tablet formulation
    Patent number: 8003126
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: August 23, 2011
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi
  • METHOD OF SYNTHESIZING TETRAHYDROBIOPTERIN
    Publication number: 20090198055
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Application
    Filed: January 6, 2009
    Publication date: August 6, 2009
    Applicant: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Muller, Philipp Schmidt, Stefan Kaiser
  • Stable tablet formulation
    Patent number: 7566462
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: July 28, 2009
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark A. Henderson, Victoria Sluzky, Robert Baffi
  • STABLE TABLET FORMULATION
    Publication number: 20080207626
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Application
    Filed: April 21, 2008
    Publication date: August 28, 2008
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi
  • Stable Tablet Formulation
    Publication number: 20070270581
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Application
    Filed: November 16, 2005
    Publication date: November 22, 2007
    Applicant: Biomarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi