Patents by Inventor Steven L. Colletti

Steven L. Colletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Amino Alcohol Cationic Lipids for Oligonucleotide Delivery
    Publication number: 20130150625
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA.
    Type: Application
    Filed: May 18, 2011
    Publication date: June 13, 2013
    Inventors: Brian W. Budzik, Steven L. Colletti, Darla Danile Seifried, Mathew G. Stanton, Lu Tian
  • Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
    Patent number: 8455520
    Abstract: Compounds of the Formula: (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating hypertension, diabetes, inflammation, atherosclerosis, pain, and the like are disclosed. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: June 4, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Steven L. Colletti, Hong Shen, Fa-Xiang Ding
  • Novel Low Molecular Weight Cationic Lipids for Oligonucleotide Delivery
    Publication number: 20130090372
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Application
    Filed: May 31, 2011
    Publication date: April 11, 2013
    Inventors: Brian W. Budzik, Steven L. Colletti, Jennifer R. Davis, Ivory D. Hills, Darla Danile Seifried, Matthew G. Stanton
  • Novel Cationic Lipids for Oligonucleotide Delivery
    Publication number: 20130053572
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is susceptible to hydrolytic instability that may translate into reduced liver residence times and reduced hepatocellular toxicity. The present invention employs acetals and ketals to provide a low pH sensitive chemical handle for degradation.
    Type: Application
    Filed: January 19, 2011
    Publication date: February 28, 2013
    Inventors: Steven L. Colletti, Zhengwu James Deng, Matthew G. Stanton, Weimin Wang, Ivory Hills
  • NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20130041133
    Abstract: In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3? and/or 5? end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
    Type: Application
    Filed: April 4, 2011
    Publication date: February 14, 2013
    Inventors: Jeffrey G. Aaronson, Stanley F. Barnett, René Bartz, Steven L. Colletti, Vasant R. Jadhav, Aaron A. Momose, Anthony W. Shaw, David M. Tellers, Thomas J. Tucker, Weimin Wang, Yu Yuan
  • ENDOSOMOLYTIC POLY(AMIDOAMINE) DISULFIDE POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20130005797
    Abstract: The present invention provides endosomolytic poly(amidoamine)disulfide polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Application
    Filed: March 14, 2011
    Publication date: January 3, 2013
    Inventors: Marina Busuek, Steven L. Colletti, Rubina G. Parmar, Weimin Wang, J. Michael Williams
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20120178750
    Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 12, 2012
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • Niacin receptor agonists, compositions containing such compounds and methods of treatment
    Patent number: 8168649
    Abstract: The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: May 1, 2012
    Assignee: Merk Sharp & Dohme Corp.
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20110039860
    Abstract: Compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof is disclosed. The compounds are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: April 27, 2009
    Publication date: February 17, 2011
    Inventors: Cangming Yang, Zhicai Wu, Rui Liang, Steven L Colletti
  • Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20110028462
    Abstract: A method of treating atherosclerosis and related conditions using compounds of formula I: as well as pharmaceutically acceptable salts and solvates is disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels.
    Type: Application
    Filed: September 15, 2006
    Publication date: February 3, 2011
    Inventors: Steven L. Colletti, Jason E. Imbriglio, Richard Thomas Beresis, Jessica Leslie Frie
  • SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20110003849
    Abstract: Compounds of the formula: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like are disclosed. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: February 24, 2009
    Publication date: January 6, 2011
    Inventors: Hong Shen, Fa-Xiang Ding, Steven L. Colletti
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20100204278
    Abstract: The present invention encompasses compounds of Formula (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: October 16, 2007
    Publication date: August 12, 2010
    Inventors: Richard T. Beresis, Steven L. Colletti
  • SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20100197691
    Abstract: Compounds of the Formula: (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating hypertension, diabetes, inflammation, atherosclerosis, pain, and the like are disclosed. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: July 11, 2008
    Publication date: August 5, 2010
    Inventors: Steven L. Colletti, Hong Shen, Fa-Xiang Ding
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20100144778
    Abstract: The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: June 26, 2006
    Publication date: June 10, 2010
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • Selective spirocyclic glucocorticoid receptor modulators
    Patent number: 7662846
    Abstract: The present invention encompasses compounds of Formula (I) and Formula (II) or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: February 16, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Amjad Ali, James M. Balkovec, Richard Beresis, Steven L. Colletti, Donald W. Graham, Gool F. Patel, Cameron J. Smith
  • Niacin receptor agonists, compositions containing such compounds and methods of treatment
    Publication number: 20090258862
    Abstract: Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: August 25, 2006
    Publication date: October 15, 2009
    Inventors: Steven L. Colletti, Hong Shen, James R. Tata, Michael J. Szymonifka
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20090170891
    Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: April 6, 2007
    Publication date: July 2, 2009
    Inventors: Steven L. Colletti, James R. Tata, Weichun Chen, Richard T. Beresis, Fa-Xiang Ding, Darby Rye Schmidt, Hong Shen, Subharekha Raghavan
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20090062269
    Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: February 2, 2007
    Publication date: March 5, 2009
    Inventors: Subharekha Raghavan, Darby Rye Schmidt, Steven L. Colletti, Abigail Lee Smenton
  • Niacin receptor agonists, compositions containing such compounds and methods of treatment
    Publication number: 20090054423
    Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: April 7, 2006
    Publication date: February 26, 2009
    Inventors: Jason E. Imbriglio, Steven L. Colletti, James R. Tata, Rui Liang, Subharekha Raghavan, Darby R. Schmidt, Abigail L. Smenton, Sook Yee Chan
  • Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
    Publication number: 20090042926
    Abstract: The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: December 20, 2006
    Publication date: February 12, 2009
    Inventors: Jason Imbriglio, Steven L. Colletti, James R. Tata, Richard T. Beresis, Daria Marley, Subharekha Raghavan, Darby Rye Schmidt, Ashley Rouse Lins, Abigail L. Smenton, Weichun Chen, Hong Shen, Fa-Xiang Ding, Rena Bodner