Patents by Inventor Steven L. Stice

Steven L. Stice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250019650
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Application
    Filed: April 29, 2024
    Publication date: January 16, 2025
    Applicants: Aruna Bio, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracey A. Stice
  • Patent number: 12139723
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative disease.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 12, 2024
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIO, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracey A. Stice
  • Patent number: 11993787
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 28, 2024
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Aruna Bio, Inc.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • Publication number: 20230173094
    Abstract: Disclosed herein are binding agents, conjugates, and extracellular vesicles that enhance penetration of the blood brain barrier. Uses thereof for delivery of agents, e.g., therapeutic agents, to the central nervous system are also provided.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 8, 2023
    Applicant: Aruna Bio, Inc.
    Inventors: Steven L. Stice, Raymond Swetenburg
  • Publication number: 20220409738
    Abstract: Disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, to the central nervous system of a subject, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) conjugated to the surface of an extracellular vesicle (EV) derived from a neural cell, e.g., a neural progenitor cell or a neural stem cell. Conjugates comprising neural EVs coupled to a polypeptide, such as an antibody or antigen binding portion thereof, and methods of use thereof, are also provided. Also disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) loaded within the lumen of an extracellular vesicle (EV) derived from neural cells.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 29, 2022
    Applicant: Aruna Bio, Inc.
    Inventors: Steven L. Stice, Raymond Swetenburg, Rhianna K. Carty
  • Publication number: 20220356444
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative disease.
    Type: Application
    Filed: April 23, 2021
    Publication date: November 10, 2022
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracey A. Stice
  • Patent number: 11332718
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: May 17, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Steven L Stice, Franklin West, Yangqing Lu
  • Patent number: 11111475
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: September 7, 2021
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIO, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • Publication number: 20200208119
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Application
    Filed: November 4, 2019
    Publication date: July 2, 2020
    Inventors: STEVEN L. STICE, FRANKLIN WEST, YANGQING LU
  • Patent number: 10501726
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: December 10, 2019
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Steven L Stice, Franklin West, Yangqing Lu
  • Publication number: 20190352603
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 21, 2019
    Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIOMEDICAL, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • Publication number: 20180327714
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Application
    Filed: November 16, 2016
    Publication date: November 15, 2018
    Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIOMEDICAL, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • Publication number: 20160333319
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Application
    Filed: May 25, 2016
    Publication date: November 17, 2016
    Inventors: Steven L Stice, Franklin West, Yangqing Lu
  • Publication number: 20150320833
    Abstract: Mesenchymal stem cells (MSCs) and uses thereof are provided. MSCs for inducing ossification and enhancing bone and/qr cartilage repair in a patient in need thereof are also provided. The method and compositions combine MSCs, at least one bone regeneration protein, such as bone morphogenetic protein (e.g. BMP-2), optionally in combination with additional cell growth factors including the components of a cell growth medium, further in combination with a biomaterial for delivery of the cells to the repair site in the patient are also provided.
    Type: Application
    Filed: December 13, 2013
    Publication date: November 12, 2015
    Inventors: Steven L. STICE, John F. PERONI, Jennifer MUMAW
  • Publication number: 20140363467
    Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lin28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
    Type: Application
    Filed: December 9, 2013
    Publication date: December 11, 2014
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Steven L. Stice, Franklin West, Yangqing Lu
  • Publication number: 20130007904
    Abstract: Genetic material is derived from animals post-mortem, and used in nuclear transfer processes to produce cloned embryos and live cloned animals having genetic make-ups identical to the post mortem animals. The method has particular applicability to the management and breeding of livestock, to the production of animals having desired genetic traits, and to the integration of those genetic traits into selective breeding operations.
    Type: Application
    Filed: May 29, 2012
    Publication date: January 3, 2013
    Applicants: Viagen, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Steven L. Stice, John Gibbons, Donald Respess
  • Publication number: 20110277049
    Abstract: Genetic material is derived from animals post-mortem, and used in nuclear transfer processes to produce cloned embryos and live cloned animals having genetic make-ups identical to the post mortem animals. The method has particular applicability to the management and breeding of livestock, to the production of animals having desired genetic traits, and to the integration of those genetic traits into selective breeding operations.
    Type: Application
    Filed: July 21, 2011
    Publication date: November 10, 2011
    Applicant: The University of Georgia Research Foundation, Inc
    Inventors: Steven L. Stice, John Gibbons, Donald Respess
  • Patent number: 7291764
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: November 6, 2007
    Assignee: University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst
    Inventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke
  • Publication number: 20040226058
    Abstract: A culture system for maintaining avian PGCs for long periods in tissue culture is provided. This culture system uses LIF, bFGF, IGF-I and SCF. The resultant PGCs are useful for the production of transgenic and chimeric avians, in particular, chickens or turkeys.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 11, 2004
    Applicant: University of Massachusetts, a public institution of higher education of the commonwealth of Massach
    Inventors: F. Abel de Leon, Catherine Blackwell, Xiu Ying Gao, James M. Robl, Steven L. Stice, D. Joseph Jerry
  • Publication number: 20040194159
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 30, 2004
    Applicant: University of Massachusetts
    Inventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke