Patents by Inventor Steven L. Stice

Steven L. Stice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultured inner cell mass cell lines derived from bovine or porcine embryos
    Patent number: 5905042
    Abstract: Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNAs may be introduced into the subject CICM cells and cell lines to produce transgenic cells useful for the production of transgenic embryos, fetuses and/or offspring, e.g., by nuclear transfer procedures.
    Type: Grant
    Filed: April 1, 1996
    Date of Patent: May 18, 1999
    Assignee: University of Massachusetts, A Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus
    Inventors: Steven L. Stice, Paul J. Golueke
  • Parthenogenic bovine oocyte activation
    Patent number: 5843754
    Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intercellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca.sup.2+ free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: ABS Global, Inc.
    Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice
  • Parthenogenic oocyte activation
    Patent number: 5496720
    Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intercellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca.sup.2+ free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: March 5, 1996
    Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice